Sphingosine Kinase Inhibitor I (SKI-I) is a chemical compound recognized for its role in inhibiting sphingosine kinase, an enzyme involved in the metabolism of sphingolipids. This inhibition can affect various cellular processes, including cell proliferation, survival, and apoptosis, making SKI-I a subject of interest in cancer research and other diseases linked to sphingolipid signaling. The compound is characterized by its specific molecular structure, which allows it to selectively bind to the active site of sphingosine kinase, thereby blocking its activity. SKI-I has been studied for its potential therapeutic applications, particularly in oncology, where modulation of sphingosine kinase activity may influence tumor growth and response to treatment. Additionally, its effects on various signaling pathways highlight its importance in understanding the complex roles of sphingolipids in cellular physiology. As with many inhibitors, the efficacy and specificity of SKI-I can vary based on the biological context, necessitating further research to fully elucidate its mechanisms and potential clinical applications.

Sphingosine Kinase Inhibitor, SKI-I

306301-68-8: Sphingosine Kinase Inhibitor I (SKI-I) is a chemical compound recognized for its role in inhibiting sphingosine kinase, an enzyme involved in the metabolism of sphingolipids. This inhibition can affect various cellular processes, including cell proliferation, survival, and apoptosis, making SKI-I a subject of interest in cancer research and other diseases linked to sphingolipid signaling. The compound is characterized by its specific molecular structure, which allows it to selectively bind to the active site of sphingosine kinase, thereby blocking its activity. SKI-I has been studied for its potential therapeutic applications, particularly in oncology, where modulation of sphingosine kinase activity may influence tumor growth and response to treatment. Additionally, its effects on various signaling pathways highlight its importance in understanding the complex roles of sphingolipids in cellular physiology. As with many inhibitors, the efficacy and specificity of SKI-I can vary based on the biological context, necessitating further research to fully elucidate its mechanisms and potential clinical applications.

<p>SKI-I is a sphingosine kinase inhibitor. SKI-I is an antibody that binds to the protein and inhibits the interaction between sphingosine kinase and its target receptors, ion channels, and other proteins. SKI-I has shown to be a highly pure material with a purity of &gt;99% by HPLC, which can be used as a research tool for cell biology and pharmacology studies.</p>

Sphingosine kinase inhibitor, SKI-I

<p>SKI-I: Human sphingosine kinase inhibitor, IC50 1.2μM; hERK2 inhibitor, IC50 11μM; promotes tumor cell apoptosis.</p>

CAS 306301-68-8

Sphingosine Kinase Inhibitor, SKI-I

Sphingosine kinase inhibitor, SKI-I

Ref: 3D-GMA30168

SKI-I

Ref: TM-T62022