Tau ligand-1, identified by its CAS number 3063166-64-0, is a chemical compound that has garnered attention in the field of neuroscience and pharmacology, particularly for its potential role in tauopathies, which are neurodegenerative diseases characterized by the aggregation of tau protein. This ligand is known for its ability to selectively bind to tau protein, influencing its aggregation and potentially modulating its pathological effects. The compound's structure typically includes functional groups that facilitate its interaction with tau, although specific structural details may vary. In terms of solubility, Tau ligand-1 is often designed to be soluble in biological solvents, enhancing its bioavailability for in vitro and in vivo studies. Its efficacy and safety profile are subjects of ongoing research, as scientists explore its therapeutic potential in treating conditions like Alzheimer's disease. Overall, Tau ligand-1 represents a promising avenue for drug development aimed at mitigating tau-related neurodegeneration.

Tau ligand-1

3063166-64-0: Tau ligand-1, identified by its CAS number 3063166-64-0, is a chemical compound that has garnered attention in the field of neuroscience and pharmacology, particularly for its potential role in tauopathies, which are neurodegenerative diseases characterized by the aggregation of tau protein. This ligand is known for its ability to selectively bind to tau protein, influencing its aggregation and potentially modulating its pathological effects. The compound's structure typically includes functional groups that facilitate its interaction with tau, although specific structural details may vary. In terms of solubility, Tau ligand-1 is often designed to be soluble in biological solvents, enhancing its bioavailability for in vitro and in vivo studies. Its efficacy and safety profile are subjects of ongoing research, as scientists explore its therapeutic potential in treating conditions like Alzheimer's disease. Overall, Tau ligand-1 represents a promising avenue for drug development aimed at mitigating tau-related neurodegeneration.

<p>Tau ligand-1 (Compound 75) is a ligand of aggregated tau protein that can penetrate the blood-brain barrier. In tissues affected by Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and Pick's disease, Tau ligand-1 shows high affinity for aggregated tau protein, with equilibrium dissociation constants (KD) ranging from 1 to 3.8 nM. It holds potential as a positron emission tomography (PET) tracer for imaging studies of tau-related diseases within the central nervous system.</p>

CAS 3063166-64-0

Tau ligand-1

Tau ligand-1

Ref: TM-T206168