CAS 3064260-49-4

COX-2-IN-51

CAS: 3064260-49-4

COX-2-IN-51 (E25) is a potent COX-2 inhibitor with an IC50 of 70.7 nM. It significantly suppresses LPS-induced release of NO and PGE2, the expression of COX-2 and iNOS, and the activation of the NF-κB pathway. Displaying anti-inflammatory and analgesic effects in various mouse models through NF-κB pathway inhibition, COX-2-IN-51 has lower gastrointestinal side effects compared to Indomethacin.

Formula: C₂₃H₁₈F₄O₃S

Color and Shape: Solid

Molecular weight: 450.446

Ref: TM-T204857