CAS 30652-11-0

Deferiprone

Description:

Deferiprone is a synthetic chelating agent primarily used in the treatment of iron overload conditions, particularly in patients with thalassemia and other chronic anemias requiring frequent blood transfusions. Its chemical formula is C10H14N2O5, and it functions by binding excess iron in the body, facilitating its excretion through urine. Deferiprone is characterized by its ability to form stable complexes with ferric ions, which helps to reduce iron accumulation in tissues and mitigate associated complications. The substance is typically administered orally and is known for its relatively favorable side effect profile compared to other iron chelators. However, it can cause agranulocytosis, a potentially serious decrease in white blood cell count, necessitating regular monitoring of blood parameters during treatment. Deferiprone's efficacy and safety have been established through various clinical studies, making it a valuable option in managing iron overload. Its unique mechanism of action and pharmacokinetic properties distinguish it from other chelating agents, contributing to its role in improving patient outcomes in iron overload disorders.

Formula: C₇H₉NO₂

InChI: InChI=1S/C7H9NO2/c1-5-7(10)6(9)3-4-8(5)2/h3-4,10H,1-2H3

InChI key: InChIKey=TZXKOCQBRNJULO-UHFFFAOYSA-N

SMILES: OC1=C(C)N(C)C=CC1=O

Synonyms:

• 1,2-Dimethyl-3-hydroxy-4(1H)-pyridinone
• 1,2-Dimethyl-3-hydroxy-4-pyridone
• 1,2-Dimethyl-3-hydroxypyridin-4-one
• 1,2-Dimethyl-3-hydroxypyridine-4-one
• 2-Hydroxy-1,3-Dimethyl-Pyridin-4-One
• 3-Hydroxy-1,2-Dimethyl-4(1H)-Pyridone
• 3-Hydroxy-1,2-dimethyl-1,4-dihydropyridin-4-one
• 3-Hydroxy-1,2-dimethyl-4(1H)-pyridinone
• 3-Hydroxy-1,2-dimethyl-4-pyridinone
• 3-Hydroxy-1,2-dimethyl-4-pyridone
• 3-hydroxy-1,2-dimethylpyridin-4(1H)-one
• 4(1H)-Pyridinone, 3-hydroxy-1,2-dimethyl-
• 4(1H)-Pyridone, 3-hydroxy-1,2-dimethyl-
• Apo 66
• CP 20 (chelating agent)
• Cgp 37391
• Cp 20
• Deferione
• Dn 18001Af
• Ferinil
• Ferriprox

3-Hydroxy-1,2-dimethyl-4(1H)-pyridone

CAS: 30652-11-0

Formula: C₇H₉NO₂

Purity: >98.0%(GC)(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 139.15

Ref: 3B-H0944

DEFERIPRONE CRS

CAS: 30652-11-0

DEFERIPRONE CRS

Ref: 41-Y0001976

4(1H)-Pyridinone, 3-hydroxy-1,2-dimethyl-

CAS: 30652-11-0

Formula: C₇H₉NO₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 139.1519

Ref: IN-DA0030RL

Deferiprone

CAS: 30652-11-0

Deferiprone (Deferidone) is an Iron Chelator. The mechanism of action of deferiprone is as an Iron Chelating Activity.

Formula: C₇H₉NO₂

Purity: 99.58% - ≥95%

Color and Shape: White Needles

Molecular weight: 139.15

Ref: TM-T1565

Deferiprone

CAS: 30652-11-0

Formula: C₇H₉NO₂

Color and Shape: White To Off-White Solid

Molecular weight: 139.15

Ref: 4Z-D-501

Deferiprone

CAS: 30652-11-0

Formula: C₇H₉NO₂

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 139.15

Ref: 7W-GP5718

Deferiprone

CAS: 30652-11-0

Deferiprone

Purity: ≥95%

Molecular weight: 139.15g/mol

Ref: 54-BUP18475

Deferiprone

CAS: 30652-11-0

Color and Shape: Neat

Ref: 86-MM0975.00

3-Hydroxy-1,2-dimethyl-4(1H)-pyridone

CAS: 30652-11-0

3-Hydroxy-1,2-dimethyl-4(1H)-pyridone

Purity: 98%

Molecular weight: 139.15g/mol

Ref: 54-OR322144

Deferiprone

Controlled Product

CAS: 30652-11-0

Applications A chelator that could replace disferrioxamine. It is orally and parenterally effective in the removal of iron in vivo from rabbits and mice and also from transferrin and ferritin in vitro.
References Kontoghiorghes, G.J.: Lancet I, 817 (1985), Kontoghiorghes, G.J., et al.: Br. J. Haematol., 62, 607 (1986), Kontoghiorghes, G.J., et al.: Biochem. Biophys. Acta, 869, 141 (1986), Kontoghiorghes, G.J., et al.: Arzneim.-Forsch., 37, 1099 (1987),

Formula: C₇H₉NO₂

Color and Shape: White To Off-White

Molecular weight: 139.15

Ref: TR-D474000

3-Hydroxy-1,2-dimethylpyridin-4(1H)-one

CAS: 30652-11-0

Formula: C₇H₉NO₂

Purity: 97%

Color and Shape: White to very pale yellow powder

Molecular weight: 139.154

Ref: 10-F239607

Deferiprone

CAS: 30652-11-0

Deferiprone is a drug used to treat iron overload. It is an organoiron compound that competitively inhibits ferrochelatase, the enzyme responsible for the last step in heme synthesis. Deferiprone prevents the accumulation of iron in tissues and organs, as well as reversing or delaying organ damage caused by excess iron. Deferiprone has been shown to be effective in treating congestive heart failure, cellular physiology disorders, and infectious diseases such as malaria. This drug also has anti-inflammatory properties which may be related to its ability to inhibit prostaglandin synthesis.

Formula: C₇H₉NO₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 139.15 g/mol

Ref: 3D-FD20884