CAS 3066-84-0

8-Bromoguanine

Description:

8-Bromoguanine is a halogenated derivative of guanine, a nucleobase essential for the structure of DNA and RNA. Its chemical formula is C5H5BrN5O, and it features a bromine atom substituted at the 8-position of the guanine structure. This modification can influence the molecule's hydrogen bonding and base pairing properties, potentially leading to mutagenic effects during DNA replication. 8-Bromoguanine is known to mimic guanine in nucleic acid structures, which can result in mispairing with cytosine or thymine, thereby contributing to genetic mutations. The compound is often used in biochemical research to study DNA repair mechanisms and the effects of halogenated bases on genetic stability. Additionally, it has applications in the development of antiviral and anticancer agents due to its ability to interfere with nucleic acid metabolism. As with many halogenated compounds, 8-bromoguanine should be handled with care due to potential toxicity and environmental concerns.

Formula: C₅H₄BrN₅O

InChI: InChI=1S/C5H4BrN5O/c6-4-8-1-2(9-4)10-5(7)11-3(1)12/h(H4,7,8,9,10,11,12)

InChI key: InChIKey=CRYCZDRIXVHNQB-UHFFFAOYSA-N

SMILES: O=C1C2=C(N=C(Br)N2)NC(N)=N1

Synonyms:

• 6H-Purin-6-one, 2-amino-8-bromo-1,7-dihydro-
• 2-Amino-8-bromo-1,9-dihydro-6H-purin-6-one
• 6H-Purin-6-one, 2-amino-8-bromo-1,9-dihydro-
• 8-Bromoguanine
• Guanine, 8-bromo-

6H-Purin-6-one, 2-amino-8-bromo-1,9-dihydro-

CAS: 3066-84-0

Formula: C₅H₄BrN₅O

Purity: 95%

Color and Shape: Solid

Molecular weight: 230.0222

Ref: IN-DA0030SI

8-Bromoguanine

CAS: 3066-84-0

8-Bromoguanine

Purity: 98%

Molecular weight: 230.02g/mol

Ref: 54-OR1026647

8-Bromoguanine

CAS: 3066-84-0

Formula: C₅H₄BrN₅O

Purity: (HPLC) ≥ 97.0%

Color and Shape: White to off-white powder

Molecular weight: 230.02

Ref: 7W-GE4745

8-Bromoguanine

CAS: 3066-84-0

8-Bromoguanine is a nucleoside analog drug that is used as an antileukemic agent. It is a synthetic derivative of guanine and has been shown to inhibit the growth of leukemic cells by interfering with the synthesis of DNA. 8-Bromoguanine has also been shown to be reactive with eosinophil peroxidase and other electron-rich substances, which may be due to its hydroxyl group. The analytical method for 8-bromoguanine includes fluorescence spectroscopy, high pressure liquid chromatography (HPLC), and thin layer chromatography (TLC). Chemical diversity studies have shown that 8-bromoguanine can react with glycosylase or hydroxy groups, forming reaction products.

Formula: C₅H₄BrN₅O

Purity: Min. 97 Area-%

Color and Shape: Powder

Molecular weight: 230.02 g/mol

Ref: 3D-FB08785

2-amino-8-bromo-6,7-dihydro-1H-purin-6-one

CAS: 3066-84-0

Purity: 95%

Molecular weight: 230.0249939

Ref: 10-F861434