CAS 3067572-78-2

2-Propenamide, N-(2-hydroxyethyl)-3-[2-(1H-indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]-, (2E)-

Description:

2-Propenamide, N-(2-hydroxyethyl)-3-[2-(1H-indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]-, (2E)- is a complex organic compound characterized by its unique structural features, which include a propenamide backbone, a hydroxyethyl substituent, and a thieno[3,2-d]pyrimidine moiety. This compound exhibits a range of functional groups, including an amide, hydroxyl, and aromatic systems, which contribute to its potential biological activity and solubility properties. The presence of the indazole and morpholine rings suggests that it may interact with various biological targets, making it of interest in medicinal chemistry. Its molecular structure indicates potential for hydrogen bonding and other intermolecular interactions, which can influence its reactivity and stability. Additionally, the compound's stereochemistry, denoted by the (2E) configuration, implies specific geometric arrangements that may affect its pharmacological properties. Overall, this compound represents a class of synthetic molecules that could be explored for therapeutic applications, particularly in the fields of oncology or neurology, given the structural motifs present.

Formula: C₂₂H₂₂N₆O₃S

Synonyms:

• 2-Propenamide, N-(2-hydroxyethyl)-3-[2-(1H-indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]-, (2E)-

PI3K-IN-58

CAS: 3067572-78-2

PI3K-IN-58 (Compound 17f) is an inhibitor of PI3Kα with an IC50 value of 0.039 μM. It shows significant antiproliferative effects on PC-3, 22RV1, MDA-MB-231, and MDA-MB-453 cell lines with IC50 values of 3.48 μM, 1.06 μM, 2.21 μM, and 0.93 μM, respectively. PI3K-IN-58 induces apoptosis by downregulating the expression of anti-apoptotic proteins Bcl-XL and Bcl-2 while upregulating the expression of the pro-apoptotic protein BAX. This compound is applicable for research in cancer targeting through PI3K pathways.

Formula: C₂₂H₂₂N₆O₃S

Color and Shape: Solid

Molecular weight: 450.51

Ref: TM-T207435