CAS 3069831-25-7

HDAC-IN-27 dihydrochloride

CAS: 3069831-25-7

HDAC-IN-27 dihydrochloride (Compound 11h) is a potent, orally active, HDACI class-selective inhibitor, with IC50 values ranging from 0.43 to 3.01 nM for HDAC1-3. This compound exhibits both in vivo and in vitro anticancer activity. HDAC-IN-27 shows significant antiproliferative effects against acute myeloid leukemia (AML) cell lines by inducing apoptosis and histone acetylation (AcHH3 and AcHH4). It is useful for research on acute myeloid leukemia (AML).

Formula: C₂₀H₂₄Cl₂N₄O₂

Color and Shape: Solid

Molecular weight: 423.336

Ref: TM-T206628