CAS 307510-92-5

CFTR(inh)-172

Description:

CFTR(inh)-172, with the CAS number 307510-92-5, is a small molecule inhibitor specifically targeting the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This compound is primarily utilized in research settings to study the function of CFTR, which is a chloride channel critical for maintaining the balance of salt and water on epithelial surfaces. CFTR(inh)-172 is known to inhibit the channel's activity, thereby providing insights into the physiological and pathophysiological roles of CFTR in various tissues, particularly in the lungs and pancreas. The compound is often employed in experiments to explore the effects of CFTR inhibition on ion transport and fluid secretion, which are crucial in understanding cystic fibrosis and other related disorders. Additionally, CFTR(inh)-172 has been used to investigate potential therapeutic strategies aimed at modulating CFTR function. Its chemical structure and properties facilitate its role as a selective inhibitor, making it a valuable tool in both basic and applied biomedical research.

Formula: C₁₈H₁₀F₃NO₃S₂

InChI: InChI=1/C18H10F3NO3S2/c19-18(20,21)12-2-1-3-13(9-12)22-15(23)14(27-17(22)26)8-10-4-6-11(7-5-10)16(24)25/h1-9H,(H,24,25)/b14-8+

InChI key: InChIKey=JIMHYXZZCWVCMI-UHFFFAOYSA-N

SMILES: O=C1N(C(=S)SC1=CC2=CC=C(C(O)=O)C=C2)C3=CC(C(F)(F)F)=CC=C3

Synonyms:

• 3-[(3-Trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone
• CFTR(inh)-172
• Benzoic acid, 4-[[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]-
• Cystic fibrosis transmembrane conductance regulator inhibitor CFTR(inh)-172
• 4-[[4-Oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]benzoic acid
• 4-[(Z)-[4-Oxo-2-Sulfanylidene-3-[3-(Trifluoromethyl)Phenyl]-1,3-Thiazolidin-5-Ylidene]Methyl]Benzoic Acid
• CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem
• 4-[[4-Oxo-2-thioxo-3-[3-trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]benzoicacid
• CFTR INHIBITOR-172
• CS-1067
• 5-[(4-CARBOXYPHENYL)METHYLENE]-2-THIOXO-3-[(3-TRIFLUOROMETHYL)PHENYL-4-THIAZOLIDINONE]
• CFTRinh-172 USP/EP/BP
• 4-[4-OXO-2-THIOXO-3-(3TRIFLUOROMETHYL-PHENYL)-THIAZOLIDIN-5-YLIDENEMETHYL]-BENZOIC ACID (FOR R&D ONLY)
• 4-[[4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid
• InSolution CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem
• InSolution? CFTR Inhibitor-172
• 4-[[4-Oxo-2-Thioxo-3-[3-(Trifluoromethyl)Phenyl]Thiazolidin-
• CFTRinh 172 (CFTR Inhibitor-172)

Benzoic acid, 4-[[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]-

CAS: 307510-92-5

Formula: C₁₈H₁₀F₃NO₃S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 409.4021

Ref: IN-DA00314S

Cftr(Inh)-172

CAS: 307510-92-5

Cftr(Inh)-172

Purity: 98%

Molecular weight: 409.40g/mol

Ref: 54-PC105310

CFTR(inh)-172

CAS: 307510-92-5

CFTR(inh)-172

Purity: ≥98%

Molecular weight: 409.4g/mol

Ref: 54-BUP03252

CFTR(inh)-172

CAS: 307510-92-5

Formula: C₁₈H₁₀F₃NO₃S₂

Purity: ≥ 95.0%

Color and Shape: Yellow powder or solid

Molecular weight: 409.40

Ref: 7W-GL0322

CFTR(inh)-172

CAS: 307510-92-5

CFTR(inh)-172 (CFTR Inhibitor-172) is a voltage-independent, selective CFTR inhibitor.

Formula: C₁₈H₁₀F₃NO₃S₂

Purity: 98% - 99.72%

Color and Shape: Solid

Molecular weight: 409.4

Ref: TM-T2355

CFTR Inhibitor-172

Controlled Product

CAS: 307510-92-5

Formula: C₁₈H₁₀F₃NO₃S₂

Color and Shape: Neat

Molecular weight: 409.402

Ref: TR-C291725