CAS 308242-62-8

Remimazolam

Description:

Remimazolam is a novel ultra-short-acting benzodiazepine that is primarily used as an anesthetic agent. It is characterized by its rapid onset and offset of action, making it suitable for procedural sedation and anesthesia. The substance acts as a positive allosteric modulator of the GABA-A receptor, enhancing the inhibitory effects of gamma-aminobutyric acid (GABA) in the central nervous system. Remimazolam is notable for its unique metabolism, which occurs through tissue esterases, leading to a quick breakdown into an inactive metabolite, thereby minimizing the risk of prolonged sedation. This property allows for precise control over sedation levels during medical procedures. Additionally, remimazolam has a favorable safety profile, with a lower incidence of adverse effects compared to traditional benzodiazepines. Its pharmacokinetic properties, including rapid clearance and short half-life, make it an attractive option for outpatient procedures where quick recovery is essential. Overall, remimazolam represents a significant advancement in anesthetic agents, combining efficacy with safety and convenience.

Formula: C₂₁H₁₉BrN₄O₂

InChI: InChI=1S/C21H19BrN4O2/c1-13-12-24-21-17(7-9-19(27)28-2)25-20(16-5-3-4-10-23-16)15-11-14(22)6-8-18(15)26(13)21/h3-6,8,10-12,17H,7,9H2,1-2H3/t17-/m0/s1

InChI key: InChIKey=CYHWMBVXXDIZNZ-KRWDZBQOSA-N

SMILES: CC=1N2C=3C(C(=N[C@@H](CCC(OC)=O)C2=NC1)C4=CC=CC=N4)=CC(Br)=CC3

Synonyms:

• 4H-Imidazo[1,2-a][1,4]benzodiazepine-4-propanoic acid, 8-bromo-1-methyl-6-(2-pyridinyl)-, methyl ester, (4S)-
• CNS 7056
• Remimazolam
• Methyl 3-{(4S)-8-bromo-1-methyl-6-(pyridin-2-yl)-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl}propanoate
• ONO 2745
• Remimazolam Tosylate
• Vibegron
• CS-638
• Methyl 3-[(4S)-8-bromo-1-methyl-6-(2-pyridyl)-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propanoate
• CNS-7056;CNS7056;CNS 7056
• methyl 3-[(4S)-8-bromo-1-methyl-6-pyridin-2-yl-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propanoate CNS-7056 Remimazolam

Remimazolam

Controlled Product

CAS: 308242-62-8

Applications Remimazolam, is a drug and benzodiazepine derivative. It is used as an alternative to the Midazolam (M343000) for anaesthesia and conscious sedation for minor invasive surgeries. It is found to be both faster and shorter lasting than midazolam (M343000).
References Rogers W.K., et al.: Investigation. Drugs J., 13 (12), 929 (2010); Saari, T. I., et al.: Pharmacol. Review., 63 (1), 243 (2011);

Formula: C₂₁H₁₉BrN₄O₂

Color and Shape: Neat

Molecular weight: 439.31

Ref: TR-R143600

Remimazolam

Controlled Product

CAS: 308242-62-8

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Formula: C₂₁H₁₉BrN₄O₂

Purity: Min. 95%

Molecular weight: 439.3 g/mol

Ref: 3D-FR181797