CAS 30868-30-5

Pyrazofurin

Description:

Pyrazofurin is a synthetic nucleoside analog with notable antiviral properties, primarily targeting RNA viruses. It is characterized by its pyrazole ring structure, which is essential for its biological activity. The compound exhibits a mechanism of action that involves the inhibition of viral RNA synthesis, making it a potential therapeutic agent against various viral infections. Pyrazofurin is soluble in water and exhibits moderate stability under physiological conditions. Its pharmacological profile includes antiviral efficacy, although its use may be limited by factors such as toxicity and resistance development in viral populations. Research has indicated that it may also possess immunomodulatory effects, contributing to its overall antiviral activity. As with many nucleoside analogs, careful consideration of dosage and administration is crucial to maximize therapeutic benefits while minimizing adverse effects. Ongoing studies continue to explore its potential applications in treating viral diseases, particularly in the context of emerging viral threats.

Formula: C₉H₁₃N₃O₆

InChI: InChI=1/C9H13N3O6/c10-9(17)4-6(15)3(11-12-4)8-7(16)5(14)2(1-13)18-8/h2,5,7-8,13-16H,1H2,(H2,10,17)(H,11,12)/t2-,5-,7-,8+/m1/s1

InChI key: InChIKey=XESARGFCSKSFID-FLLFQEBCSA-N

SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)C=2C(O)=C(C(N)=O)NN2

Synonyms:

• (1S)-1,4-anhydro-1-(5-carbamoyl-4-hydroxy-1H-pyrazol-3-yl)-D-ribitol
• (1S)-1-{(5E)-5-[amino(hydroxy)methylidene]-4-oxo-4,5-dihydro-1H-pyrazol-3-yl}-1,4-anhydro-D-ribitol
• (1S)-1-{(5Z)-5-[amino(hydroxy)methylidene]-4-oxo-4,5-dihydro-1H-pyrazol-3-yl}-1,4-anhydro-D-ribitol
• 1-{(5E)-5-[amino(hydroxy)methylidene]-4-oxo-4,5-dihydro-1H-pyrazol-3-yl}-1,4-anhydropentitol
• 1H-Pyrazole-5-carboxamide, 4-hydroxy-3-beta-D-ribofuranosyl-
• 1H-Pyrazole-5-carboxamide, 4-hydroxy-3-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• 4-Hydroxy-3-beta-<span class="text-smallcaps">D</span>-ribofuranosylpyrazole-5-carboxamide
• 4-Hydroxy-3-beta-D-ribofuranosylpyrazole-5-carboxamide
• 4-Hydroxy-3-β-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-pyrazole-5-carboxamide
• Antibiotic A 23813
• NSC 143095
• Pirazofurin
• Przf
• Pyrazole-3-carboxamide, 4-hydroxy-5-beta-L-ribofuranosyl-
• Pyrazomycin
• Pyrozofurin
• beta-Pyrazomycin
• β-Pyrazofurin
• β-Pyrazomycin
• 1H-Pyrazole-5-carboxamide, 4-hydroxy-3-β-D-ribofuranosyl-
• Pyrazofurin
• 4-Hydroxy-3-β-D-ribofuranosyl-1H-pyrazole-5-carboxamide
• 3-beta-d-ribofuranosyl-4-hydroxypyrazole-5-carboxamide
• compound47599
• nsc143095
• 47599
• 4-HYDROXY-3-BETA-D-RIBOFURANOSYL-1H-PYRAZOLE-5-CARBOXAMIDE MONOHYDRATE
• 4-hydroxy-3-beta-d-ribofuranosyl-1h-pyrazole-5-carboxamide
• A-23813
• 4-hydroxy-3-beta-d-ribofuranosyl-1h-pyrazole-5-carboxamid
• PYRAZOFURIN MONOHYDRATE

4-HYDROXY-3-β-D-RIBOFURANOSYL-1H-PYRAZOLE-5-CARBOXAMIDE MONOHYDRATE

CAS: 30868-30-5

Formula: C₉H₁₃N₃O₆

Purity: 97%

Color and Shape: Solid

Molecular weight: 259.2160

Ref: IN-DA00BE0N

3-((2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxy-1H-pyrazole-5-carboxamide

CAS: 30868-30-5

3-((2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxy-1H-pyrazole-5-carboxamide

Purity: 97%

Molecular weight: 259.22g/mol

Ref: 54-OR1074824

Pyrazofurin

CAS: 30868-30-5

Pyrazofurin is an antiviral drug that inhibits viral DNA synthesis by inhibiting the enzyme ribonucleotide reductase. It has been shown to be effective for bowel disease in mice and murine hepatoma cells. Pyrazofurin binds to the pyrazole ring of the enzyme, thereby inhibiting its activity and preventing the formation of uridine triphosphate (UTP) from uridine monophosphate (UMP). This compound also has anti-cancer activities, which may be due to its ability to inhibit cell growth by targeting enzymes that are expressed at high levels in cancer tissues. Pyrazofurin is used as a biological sample to measure enzyme activities such as dextran sulfate and other substances that can be detected through colorimetric or fluorometric assays.

Formula: C₁₁H₁₄F₃N₃O₈

Purity: Min. 95%

Molecular weight: 373.24 g/mol

Ref: 3D-FBA86830

Pyrazofurin

CAS: 30868-30-5

Pyrazofurin, a pyrimidine analogue, blocks cell growth and DNA synthesis by targeting UMP synthase & orotate-phosphoribosyltransferase (IC50: 0.06-0.37 μM).

Formula: C₉H₁₃N₃O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 259.22

Ref: TM-T16690