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CAS 31009-31-1

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8-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline

Description:
8-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline is a chemical compound characterized by its quinoline backbone, which is a bicyclic structure containing a benzene ring fused to a pyridine ring. The presence of a fluorine atom at the 8-position and a trifluoromethyl group at the 2-position significantly influences its chemical properties, including its reactivity and lipophilicity. The hydroxy group at the 4-position contributes to its potential as a hydrogen bond donor, which can enhance its solubility in polar solvents and affect its biological activity. This compound is of interest in medicinal chemistry due to its potential applications in pharmaceuticals, particularly as an antimicrobial or antiviral agent. Its unique fluorinated structure may also impart desirable pharmacokinetic properties, such as increased metabolic stability. Additionally, the trifluoromethyl group is known to enhance the lipophilicity of compounds, which can improve membrane permeability. Overall, 8-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline exhibits a combination of features that make it a subject of interest in various chemical and biological research fields.
Formula:C10H5F4NO
InChI:InChI=1/C10H5F4NO/c11-6-3-1-2-5-7(16)4-8(10(12,13)14)15-9(5)6/h1-4H,(H,15,16)
SMILES:c1cc2c(cc(C(F)(F)F)nc2c(c1)F)O
Synonyms:
  • 8-Fluoro-2-(trifluoromethyl)quinolin-4-ol
  • 6-fluoro-2-(trifluoromethyl)quinolin-4(1H)-one
  • 8-fluoro-2-(trifluoromethyl)quinolin-4(1H)-one
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