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CAS 31036-80-3

:

Lofexidine

Description:
Lofexidine is a selective alpha-2 adrenergic agonist primarily used in the management of opioid withdrawal symptoms. It acts by reducing the release of norepinephrine, thereby alleviating symptoms associated with opioid cessation. The chemical formula of Lofexidine is C11H12Cl2N2, and it features a bicyclic structure that contributes to its pharmacological properties. This compound is typically administered in the form of hydrochloride salt, enhancing its solubility and bioavailability. Lofexidine is known for its relatively favorable side effect profile compared to other medications used for opioid withdrawal, making it a valuable option in clinical settings. It is important to note that while Lofexidine can help manage withdrawal symptoms, it is not a substitute for comprehensive addiction treatment. As with any medication, its use should be guided by a healthcare professional, considering potential interactions and contraindications. Overall, Lofexidine represents a significant advancement in the therapeutic approach to opioid dependence.
Formula:C11H12Cl2N2O
InChI:InChI=1S/C11H12Cl2N2O/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13/h2-4,7H,5-6H2,1H3,(H,14,15)
InChI key:InChIKey=KSMAGQUYOIHWFS-UHFFFAOYSA-N
SMILES:O(C(C)C=1NCCN1)C2=C(Cl)C=CC=C2Cl
Synonyms:
  • 1H-Imidazole, 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-
  • (±)-Lofexidine
  • 2-[1-(2,6-Dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole
  • 2-(1-(2,6-Dichlorophenoxy)Ethyl)-4,5-Dihydro-1H-Imidazole
  • 2-Imidazoline, 2-[1-(2,6-dichlorophenoxy)ethyl]-
  • 2-[1-(2,6-Dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole
  • 1H-imidazole, 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-
  • 2-{1-[(2,6-dichlorophenyl)oxy]ethyl}-4,5-dihydro-1H-imidazole
  • (±)-2-[1-(2,6-Dichlorophenoxy)ethyl]-2-imidazoline
  • 2-(a-(2,6-Dichlorophenoxy)ethyl)2-imidazoline
  • Lofexidine
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Found 6 products.