CAS 3106-85-2

N-Acetylaspartylglutamic acid

Description:

N-Acetylaspartylglutamic acid, commonly referred to as NAAG, is a naturally occurring dipeptide composed of the amino acids N-acetylaspartate and glutamate. It is classified as a neurotransmitter and plays a significant role in the central nervous system, particularly in modulating synaptic transmission and neuroprotection. NAAG is known to act on metabotropic glutamate receptors, influencing various physiological processes, including pain perception and neuroplasticity. The substance is soluble in water and exhibits stability under physiological conditions, making it relevant for research in neurobiology and potential therapeutic applications. Its CAS number, 3106-85-2, is used for identification in chemical databases. NAAG's involvement in neurodegenerative diseases and its potential as a biomarker for certain neurological conditions are areas of ongoing research, highlighting its importance in both basic and applied sciences.

Formula: C₁₁H₁₆N₂O₈

InChI: InChI=1S/C11H16N2O8/c1-5(14)12-7(4-9(17)18)10(19)13-6(11(20)21)2-3-8(15)16/h6-7H,2-4H2,1H3,(H,12,14)(H,13,19)(H,15,16)(H,17,18)(H,20,21)/t6-,7-/m0/s1

InChI key: InChIKey=OPVPGKGADVGKTG-BQBZGAKWSA-N

SMILES: [C@@H](C(N[C@@H](CCC(O)=O)C(O)=O)=O)(CC(O)=O)NC(C)=O

Synonyms:

• <span class="text-smallcaps">L</smallcap>-Glutamic acid, N-(N-acetyl-<smallcap>L</span>-α-aspartyl)-
• <span class="text-smallcaps">L</smallcap>-Glutamic acid, N-acetyl-<smallcap>L</span>-α-aspartyl-
• Ac-Asp-Glu-OH
• Acetyl-α-<span class="text-smallcaps">L</span>-aspartylglutamic acid
• Glutamic acid, N-(N-acetyl-<span class="text-smallcaps">L</smallcap>-aspartyl)-, <smallcap>L</span>-
• Isospaglumic Acid
• N-(N-Acetylaspartyl)glutamic acid
• N-Acetyl-<span class="text-smallcaps">L</smallcap>-aspartyl-<smallcap>L</span>-glutamic acid
• N-Acetyl-<span class="text-smallcaps">L</smallcap>-α-aspartyl-<smallcap>L</span>-glutamic acid
• N-Acetyl-α-<span class="text-smallcaps">L</smallcap>-aspartyl-<smallcap>L</span>-glutamic acid
• N-Acetyl-α-aspartylglutamic acid
• N-Acetylaspartylglutamic acid
• N-acetyl-D-alpha-aspartyl-L-glutamic acid
• N-acetyl-L-alpha-aspartyl-L-glutamic acid
• N-acetyl-alpha-aspartylglutamic acid
• α-Spaglumic acid
• L-Glutamic acid, N-acetyl-L-α-aspartyl-
• Glutamic acid, N-(N-acetyl-L-aspartyl)-, L-
• N-Acetyl-L-α-aspartyl-L-glutamic acid

Ac-Asp-Glu-OH

CAS: 3106-85-2

An endogenous dipeptide with high affinity for a brain glutamate receptor. NAAG is the most abundant peptide neurotransmitter in the mammalian central nervous system.

Formula: C₁₁H₁₆N₂O₈

Purity: > 99%

Color and Shape: White Powder

Molecular weight: 304.26

Ref: 01-4006232

L-Glutamic acid, N-acetyl-L-α-aspartyl-

CAS: 3106-85-2

Formula: C₁₁H₁₆N₂O₈

Purity: 95%

Color and Shape: Solid

Molecular weight: 304.2533

Ref: IN-DA00321K

N-Acetyl-Asp-Glu

CAS: 3106-85-2

Formula: C₁₁H₁₆N₂O₈

Purity: ≥ 95.0%

Color and Shape: White to off-white powder

Molecular weight: 304.25

Ref: 7W-GL2335

Spaglumic acid

CAS: 3106-85-2

Spaglumic acid

Purity: ≥95%

Molecular weight: 304.25g/mol

Ref: 54-BUP14509

(S)-2-((S)-2-Acetamido-3-Carboxypropanamido)Pentanedioic Acid

CAS: 3106-85-2

(S)-2-((S)-2-Acetamido-3-Carboxypropanamido)Pentanedioic Acid

Purity: 95%

Molecular weight: 304.25g/mol

Ref: 54-OR1024085

Spaglumic acid

CAS: 3106-85-2

Spaglumic acid (N-Acetylaspartylglutamic acid) is a neuropeptide found in millimolar concentrations in the brain.

Formula: C₁₁H₁₆N₂O₈

Purity: 99.92%

Color and Shape: White Powder

Molecular weight: 304.25

Ref: TM-TQ0285

Spaglumic Acid-d3

Controlled Product

CAS: 3106-85-2

Stability Hygroscopic
Applications Spaglumic Acid-d3 is the isotope labelled analogue of Spaglumic Acid, a marker of neuronal integrity and was used in the detection of therapeutic values of antidrepressant treatments.
References Taylor, M.J., et al.: Int. J. Neuropharmacol., 15, 1541 (2012); Shi, D.X., et al.: J. Neurochem., 123, 971 (2012); Sun,W., et al.: Science., 339, 197 (2013);

Formula: C₁₁H₁₃D₃N₂O₈

Color and Shape: Neat

Molecular weight: 307.27

Ref: TR-S679102

N-Acetyl-L-aspartyl-L-glutamic acid

CAS: 3106-85-2

N-Acetyl-L-aspartyl-L-glutamic acid is an amino acid that is used as a substrate in the biochemical assay for glutamate. It is also used to measure brain functions. NAAG is a low potency agonist of the NMDA receptor, which may contribute to neuronal death. NAAG is used as a model system to study bowel disease and eosinophil cationic protein. It has been shown to be effective in vitro against cancer cells and fungi. The structural analysis of NAAG has revealed that it contains an acidic group on its side chain, which can be detected with a pH indicator such as phenol red or bromocresol purple.

Formula: C₁₁H₁₆N₂O₈

Purity: Min. 95 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 304.25 g/mol

Ref: 3D-FA05316

Spaglumic Acid

Controlled Product

CAS: 3106-85-2

Applications Spaglumic Acid is a marker of neuronal integrity and was used in the detection of therapeutic values of antidrepressant treatments.
References Taylor, M.J., et al.: Int. J. Neuropharmacol., 15, 1541 (2012); Shi, D.X., et al.: J. Neurochem., 123, 971 (2012); Sun,W., et al.: Science., 339, 197 (2013);

Formula: C₁₁H₁₆N₂O₈

Color and Shape: Neat

Molecular weight: 304.25

Ref: TR-S679100

Ac-Asp-Glu • H2O

CAS: 3106-85-2

Ac-Asp-Glu • H2O is a water soluble molecule that belongs to the class of inhibitors. It has been shown to inhibit the polymerase chain reaction and is used as an analytical method for detecting DNA sequences. Ac-Asp-Glu • H2O induces neuronal death in the caudate putamen, thereby causing bowel disease, by inhibiting energy metabolism. This compound also inhibits the synthesis of proteins in the hippocampus, which leads to reduced locomotor activity and eosinophil cationic protein production. Ac-Asp-Glu • H2O is acidic and its concentration–time curve shows a bell shape. The half life of this compound is six hours.

Formula: C₁₁H₁₆N₂O₈•H₂O

Purity: Min. 95%

Molecular weight: 322.28 g/mol

Ref: 3D-PDE-4167