CAS 3114-44-1

3β-Hydroxychlormadinone acetate

Description:

3β-Hydroxychlormadinone acetate, with the CAS number 3114-44-1, is a synthetic steroid and a derivative of the natural hormone progesterone. It is primarily characterized by its anti-inflammatory and progestational properties, making it useful in various therapeutic applications, particularly in hormonal treatments and contraceptives. The compound features a steroid backbone with a hydroxyl group at the 3β position and an acetate group, which enhances its lipophilicity and bioavailability. It is typically administered in the form of oral tablets or injectable formulations. The substance exhibits a range of pharmacological effects, including the modulation of reproductive functions and the regulation of menstrual cycles. Additionally, it may have applications in treating conditions such as endometriosis and certain types of hormonal imbalances. As with many synthetic hormones, its use should be monitored due to potential side effects and contraindications. Overall, 3β-Hydroxychlormadinone acetate represents a significant compound in the field of endocrinology and reproductive health.

Formula: C₂₃H₃₁ClO₄

InChI: InChI=1S/C23H31ClO4/c1-13(25)23(28-14(2)26)10-7-18-16-12-20(24)19-11-15(27)5-8-21(19,3)17(16)6-9-22(18,23)4/h11-12,15-18,27H,5-10H2,1-4H3/t15-,16+,17-,18-,21+,22-,23-/m0/s1

InChI key: InChIKey=QQEHDZXXCDSAFE-JBSAMAPISA-N

SMILES: O(C(C)=O)[C@@]1(C(C)=O)[C@]2(C)[C@@](CC1)([C@]3([C@](CC2)([C@]4(C)C(C(Cl)=C3)=C[C@@H](O)CC4)[H])[H])[H]

Synonyms:

• (3β)-17-(Acetyloxy)-6-chloro-3-hydroxypregna-4,6-dien-20-one
• 17α-Acetoxy-6-chloro-3β-hydroxypregna-4,6-dien-20-one
• 3β-Hydroxychlormadinone acetate
• 6-Chloro-3β,17-dihydroxypregna-4,6-dien-20-one 17-acetate
• Ay 11497
• Chlormadinol acetate
• Pregna-4,6-dien-20-one, 17-(acetyloxy)-6-chloro-3-hydroxy-, (3beta)-
• Pregna-4,6-dien-20-one, 17-(acetyloxy)-6-chloro-3-hydroxy-, (3β)-
• Pregna-4,6-dien-20-one, 6-chloro-3β,17-dihydroxy-, 17-acetate

Chlormadinol Acetate-d3 (Major)

Controlled Product

CAS: 3114-44-1

Applications Chlormadinol Acetate-d3, is the labeled analogue of Chlormadinol Acetate (C343460), the active metabolite of Chlormadinone acetate (CMA) (C343500).
References Vaitukaitis, J., et al.: J. Clin. Endocrinol. Metab., 33, 988 (1971), Handy, R., et al.: Drug Metab. Disposition., 2, 214 (1974), Fiet, J., et al.: Steroids, 66, 609 (2001),

Formula: C₂₃H₂₈D₃ClO₄

Color and Shape: Neat

Molecular weight: 409.96

Ref: TR-C343463

Chlormadinol Acetate

Controlled Product

CAS: 3114-44-1

Applications The active metabolite of Chlormadinone acetate (CMA) (C343500).
References Vaitukaitis, J., et al.: J. Clin. Endocrinol. Metab., 33, 988 (1971), Handy, R., et al.: Drug Metab. Disposition., 2, 214 (1974), Fiet, J., et al.: Steroids, 66, 609 (2001),

Formula: C₂₃H₃₁ClO₄

Color and Shape: Neat

Molecular weight: 406.94

Ref: TR-C343460

Chlormadinol Acetate-d7

Controlled Product

CAS: 3114-44-1

Formula: C₂₃D₇H₂₄ClO₄

Color and Shape: Neat

Molecular weight: 413.986

Ref: TR-C343462

Chlormadinol acetate

Controlled Product

CAS: 3114-44-1

Chlormadinol acetate is a stable complex of a fatty acid and an antibiotic that is used to treat infections caused by bacteria. It has been shown to have high resistance to antimicrobial agents, including amoxicillin-clavulanic acid, tetracycline, and multidrug efflux pumps. Chlormadinol acetate has also been shown to inhibit the growth of certain cancer cells in vitro and in vivo using gene therapy. This drug also inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit and preventing the formation of a functional 70S ribosome. Chlormadinol acetate has been shown to be clinically relevant in mice when used with amoxicillin-clavulanic acid or tetracycline.

Formula: C₂₃H₃₁ClO₄

Purity: Min. 95%

Molecular weight: 406.94 g/mol

Ref: 3D-FC19934

Chlormadinone Acetate 3β-HydroxyImpurity

CAS: 3114-44-1

Formula: C₂₃H₃₁ClO₄

Molecular weight: 406.94

Ref: ST-EA-CP-C68014