CAS 31166-44-6

1-CBZ-piperazine

Description:

1-CBZ-piperazine, also known as carbobenzyloxy-piperazine, is a chemical compound characterized by the presence of a piperazine ring substituted with a carbobenzyloxy group. This compound typically appears as a white to off-white solid and is soluble in organic solvents such as dichloromethane and dimethyl sulfoxide, but has limited solubility in water. The piperazine moiety contributes to its basicity, allowing it to participate in various chemical reactions, including nucleophilic substitutions and coupling reactions. 1-CBZ-piperazine is often utilized in medicinal chemistry as a building block for the synthesis of pharmaceuticals, particularly in the development of compounds with potential therapeutic applications. Its structure allows for further modifications, making it a versatile intermediate in organic synthesis. Additionally, the presence of the carbobenzyloxy group can provide protection for the amine functionality during chemical reactions, enhancing its utility in synthetic pathways. As with many chemical substances, proper handling and safety precautions should be observed due to potential hazards associated with its use.

Formula: C₁₂H₁₆N₂O₂

InChI: InChI=1/C12H16N2O2/c15-12(14-8-6-13-7-9-14)16-10-11-4-2-1-3-5-11/h1-5,13H,6-10H2

SMILES: c1ccc(cc1)COC(=O)N1CCNCC1

Synonyms:

• Benzyl 1-Piperazinecarboxylate
• Benzyl Piperazine-1-Carboxylate
• N-Benzyloxycarbonylpiperazine
• Boc-Cys-Boc
• Piperazine-1-Carboxylic Acid Benzyl Ester

1-Carbobenzoxypiperazine

CAS: 31166-44-6

Formula: C₁₂H₁₆N₂O₂

Purity: >95.0%(GC)(T)

Color and Shape: Colorless to Red to Green clear liquid

Molecular weight: 220.27

Ref: 3B-C2178

1-(Benzyloxycarbonyl)piperazine, 98%

CAS: 31166-44-6

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₁₂H₁₇N₂O₂

Purity: 98%

Molecular weight: 221.28

Ref: 02-H56008

Benzyl 1-Piperazinecarboxylate

CAS: 31166-44-6

Formula: C₁₂H₁₆N₂O₂

Purity: 97%

Color and Shape: Liquid

Molecular weight: 220.2676

Ref: IN-DA0034I7

Piperazine, N-CBZ protected

CAS: 31166-44-6

Piperazine, N-CBZ protected

Purity: 97%

Molecular weight: 220.27g/mol

Ref: 54-OR20020

1-Cbz-Piperazine

CAS: 31166-44-6

Formula: C₁₂H₁₆N₂O₂

Purity: 97%

Color and Shape: Liquid, Oil

Molecular weight: 220.272

Ref: 10-F049047

1-Cbz-piperazine

Controlled Product

CAS: 31166-44-6

Applications 1-Cbz-piperazine is used in the synthesis of serotonin 5-HT6 and dopamine D2 receptor ligands (1,2). It can also be used for the synthesis of a 11-C labelled ligands for imaging vesicular acetylcholine transporter.
References (1) Kindahl, T. et al.: Org. Biomol. Chem., 12, 4461 (2014) (2) Krogsgaard-Larsen, N., et al.: J. Med. Chem., 57, 5823 (2014)

Formula: C₁₂H₁₆N₂O₂

Color and Shape: Neat

Molecular weight: 220.27

Ref: TR-C227775

N-Z-Piperazine

CAS: 31166-44-6

N-Z-Piperazine is a potent amide that has been shown to inhibit the activity of DPP-IV, an enzyme that degrades the incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). It also inhibits the production of fatty acids by human liver cancer cells. N-Z-Piperazine is an analog of piperazine, which is a molecule used in morphogenetic proteins. This drug is not active against human leukemia cells or other types of cancer. N-Z-Piperazine has been shown to inhibit glucose production in humans and rats, but not in mice. It has also been shown to increase serum levels of cetirizine, a histamine receptor blocker that aids in the treatment of allergies.

Formula: C₁₂H₁₆N₂O₂

Purity: Min. 95%

Color and Shape: Clear Colourless To Yellow Liquid

Molecular weight: 220.27 g/mol

Ref: 3D-FP55339