CAS 312-48-1

Edrophonium

Description:

Edrophonium is a reversible inhibitor of the enzyme acetylcholinesterase, primarily used in the diagnosis of myasthenia gravis and for the management of certain types of arrhythmias. It is a quaternary ammonium compound, which means it carries a positive charge at physiological pH, affecting its ability to cross biological membranes. Edrophonium is characterized by its rapid onset of action and short duration, typically lasting only a few minutes to an hour. The compound works by increasing the concentration of acetylcholine at neuromuscular junctions, thereby enhancing communication between nerves and muscles. It is administered via intravenous injection and is known for its relatively low toxicity profile when used appropriately. Common side effects may include muscle twitching, bradycardia, and gastrointestinal disturbances. Due to its rapid action, edrophonium is often used in clinical settings to assess the response to treatment in myasthenia gravis patients, helping to differentiate between myasthenic and cholinergic crises.

Formula: C₁₀H₁₆NO

InChI: InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1

InChI key: InChIKey=VWLHWLSRQJQWRG-UHFFFAOYSA-O

SMILES: [N+](CC)(C)(C)C1=CC(O)=CC=C1

Synonyms:

• MeSH ID: D004491
• Ammonium, ethyl(m-hydroxyphenyl)dimethyl-
• N-Ethyl-3-hydroxy-N,N-dimethylbenzenaminium
• Edrophonium
• Benzenaminium, N-ethyl-3-hydroxy-N,N-dimethyl-

Edrophonium

CAS: 312-48-1

Edrophonium: quick-acting, brief cholinesterase inhibitor for arrhythmias, myasthenia gravis diagnosis, and curare antidote.

Formula: C₁₀H₁₆NO

Color and Shape: Solid

Molecular weight: 166.24

Ref: TM-T69472