CAS 312-93-6

Dexamethasone phosphate

Description:

Dexamethasone phosphate is a synthetic corticosteroid and a derivative of dexamethasone, primarily used for its anti-inflammatory and immunosuppressive properties. It is characterized by its phosphate ester form, which enhances its solubility in water compared to its parent compound. This solubility makes it suitable for parenteral administration. The substance is often utilized in the treatment of various conditions, including allergies, autoimmune disorders, and certain types of cancer. Dexamethasone phosphate acts by binding to glucocorticoid receptors, leading to the modulation of gene expression and subsequent reduction of inflammation and immune response. Its pharmacokinetics include rapid absorption and a relatively long half-life, allowing for effective therapeutic dosing. Common side effects may include increased susceptibility to infections, fluid retention, and alterations in glucose metabolism. As with other corticosteroids, careful monitoring is essential to mitigate potential adverse effects, especially with long-term use. Overall, dexamethasone phosphate is a valuable medication in clinical practice, particularly in managing inflammatory and autoimmune conditions.

Formula: C₂₂H₃₀FO₈P

InChI: InChI=1S/C22H30FO8P/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30)/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChI key: InChIKey=VQODGRNSFPNSQE-CXSFZGCWSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](F)([C@]4(C)C(CC3)=CC(=O)C=C4)[C@@H](O)C1)[H])(C[C@@H](C)[C@@]2(C(COP(=O)(O)O)=O)O)[H]

Synonyms:

• (11β,16α)-9-Fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)pregna-1,4-diene-3,20-dione
• Betnelan phosphate
• Dexamethasone 21-dihydrogen phosphate
• Dexamethasone 21-phosphate
• Dexamethasone orthophosphate
• Dexamethasone phosphate
• Micromethason
• Pregna-1,4-Diene-3,20-Dione, 9-Fluoro-11,17-Dihydroxy-16-Methyl-21-(Phosphonooxy)-, (11Beta,16Alpha)-
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, (11β,16α)-
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-(dihydrogen phosphate)
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-phosphate
• Wymesone

Dexamethasone Phosphate

CAS: 312-93-6

Halogenated derivatives of adrenal cortical hormones

Formula: C₂₂H₃₀FO₈P

Color and Shape: White Powder

Molecular weight: 472.16623

Ref: 45-1177000

Dexamethasone 21-Phosphate-d5

CAS: 312-93-6

Formula: C₂₂H₂₅D₅FO₈P

Molecular weight: 477.48

Ref: 4Z-D-3685

Dexamethasone 21-Phosphate

CAS: 312-93-6

Formula: C₂₂H₃₀FO₈P

Molecular weight: 472.45

Ref: 4Z-D-3671

Dexamethasone phosphate

CAS: 312-93-6

Dexamethasone phosphate is a synthetic adrenal corticosteroid. It also has potent anti-inflammatory properties.

Formula: C₂₂H₃₀FO₈P

Color and Shape: Solid

Molecular weight: 472.44

Ref: TM-T23984

Dexamethasone Phosphate-D5 (Major)

Controlled Product

CAS: 312-93-6

Formula: C₂₂₂H₅H₂₅FO₈P

Color and Shape: Neat

Molecular weight: 477.47

Ref: TR-D298837

Dexamethasone 21-Phosphate Dimer Sodium Salt

Controlled Product

CAS: 1869-92-7, 312-93-6

Stability Hygroscopic
Applications Dexamethasone 21-Phosphate Dimer is a derivative of Dexamethasone (D298800), a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates T cell survival, growth, and differentiation. Dexamethasone inhibits the induction of nitric oxide synthase.
References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995), Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999), Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999)

Formula: C₄₄H₅₆F₂NaO₁₂P

Color and Shape: White Solid

Molecular weight: 868.87

Ref: TR-D298840

Dexamethasone Phosphate

CAS: 312-93-6

Applications A pro-drug of Dexamethasone (D298800), an anti-inflammatory glucocorticoid. It was found that liposomal DXM-P inhibited both chronic inflammation and joint destruction, whereas free DXM-P failed to prevent joint destruction.
References Kodelja, V., et al.: J. Immunol., 160, 1411 (1998), Metselaar, J., et al.: Arthritis Rheum., 48, 2059 (2003), Buttgereit, F., et al.: Arthritis Rheum., 50, 3408 (2004), Martinez, F., et al.: Front Biosci., 13, 453 (2008),

Formula: C₂₂H₃₀FO₈P

Color and Shape: White To Light Brown

Molecular weight: 472.44

Ref: TR-D298835

Dexamethasone 21-Phosphate Dimer-d6 Sodium Salt

Controlled Product

CAS: 312-93-6

Formula: C₄₄D₆H₅₀F₂O₁₂P·Na

Color and Shape: Neat

Molecular weight: 874.90

Ref: TR-D298842

Dexamethasone 21-Phosphate Dimer-d10 Sodium Salt

Controlled Product

CAS: 312-93-6

Formula: C₄₄D₁₀H₄₆F₂NaO₁₂P

Color and Shape: Neat

Molecular weight: 878.93

Ref: TR-D298844

Dexamethasone 21-Phosphate Dimer-d8 Sodium Salt

Controlled Product

CAS: 312-93-6

Formula: C₄₄D₈H₄₈F₂NaO₁₂P

Color and Shape: Neat

Molecular weight: 876.918

Ref: TR-D298843

Dexamethasone phosphate

CAS: 312-93-6

Dexamethasone phosphate

Formula: C₂₂H₃₀FO₈P

Purity: 99.2%

Color and Shape: White To Light Brown

Molecular weight: 472.16623

Ref: 47-646