CAS 312753-06-3

Indacaterol

Description:

Indacaterol is a long-acting beta-2 adrenergic agonist (LABA) primarily used in the management of chronic obstructive pulmonary disease (COPD) and asthma. It is characterized by its ability to relax bronchial smooth muscle, leading to bronchodilation and improved airflow. Indacaterol has a rapid onset of action and a prolonged duration of effect, allowing for once-daily dosing, which enhances patient compliance. The chemical structure of indacaterol includes a naphthalene ring, contributing to its lipophilicity and receptor affinity. It is typically administered via inhalation, utilizing a dry powder inhaler. Indacaterol's pharmacokinetics involve extensive hepatic metabolism, primarily through cytochrome P450 enzymes, and it has a favorable safety profile, although potential side effects may include cardiovascular effects and tremors. As a relatively newer agent in the LABA class, indacaterol represents an important therapeutic option for patients requiring long-term bronchodilation.

Formula: C₂₄H₂₈N₂O₃

InChI: InChI=1S/C24H28N2O3/c1-3-14-9-16-11-18(12-17(16)10-15(14)4-2)25-13-22(28)19-5-7-21(27)24-20(19)6-8-23(29)26-24/h5-10,18,22,25,27-28H,3-4,11-13H2,1-2H3,(H,26,29)/t22-/m0/s1

InChI key: InChIKey=QZZUEBNBZAPZLX-QFIPXVFZSA-N

SMILES: [C@@H](CNC1CC=2C(C1)=CC(CC)=C(CC)C2)(O)C3=C4C(=C(O)C=C3)NC(=O)C=C4

Synonyms:

• 2(1H)-Quinolinone, 5-[(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-
• 5-[(1R)-2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-2(1H)-quinolinone
• 5-{2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl}-8-hydroxyquinolin-2(1H)-one
• Indacaterol
• Qab-149

Indacaterol

CAS: 312753-06-3

Indacaterol (Onbrez; Arcapta) is a β2-Adrenergic Agonist. The mechanism of action of indacaterol is as an Adrenergic beta2-Agonist.

Formula: C₂₄H₂₈N₂O₃

Purity: 99.96%

Color and Shape: Solid

Molecular weight: 392.49

Ref: TM-T2320

Indacaterol

Controlled Product

CAS: 312753-06-3

Applications Indacaterol is a β-adrenoreceptor agonists for treatment of asthma and bronchodilator treatment for patients with chronic obstructive pulmonary diseases.
References Crisafulli, E., et al.; Expert Opinion Pharmacother., 18, 1499 (2017); Aparici, M., et al.: Pul. Pharmacol. Ther., 46, 1 (2017); Demin, I., et al.: Int. J. Clin. Pharmacol. Ther., 54, 405 (2016)

Formula: C₂₄H₂₈N₂O₃

Color and Shape: Neat

Molecular weight: 392.50

Ref: TR-I499745

Indacaterol-d10

Controlled Product

CAS: 312753-06-3

Formula: C₂₄D₁₀H₁₈N₂O₃

Color and Shape: Neat

Molecular weight: 402.552

Ref: TR-I499748

Oxo-indacaterol

Controlled Product

CAS: 312753-06-3

Formula: C₂₄H₂₆N₂O₄

Color and Shape: Neat

Molecular weight: 406.47

Ref: TR-O992575

Indacaterol

CAS: 312753-06-3

Formula: C₂₄H₂₈N₂O₃

Purity: 99%

Color and Shape: Solid

Molecular weight: 392.4907

Ref: IN-DA00C6FX