CAS 3131-23-5

4-Hydroxyestrone

Description:

4-Hydroxyestrone is a naturally occurring estrogen and a metabolite of estrone, classified under the category of phenolic compounds. It is characterized by the presence of a hydroxyl group (-OH) at the 4-position of the estrone structure, which contributes to its biological activity. This compound is a steroid hormone and plays a role in various physiological processes, including the regulation of the menstrual cycle and reproductive functions. 4-Hydroxyestrone exhibits estrogenic activity, influencing cell proliferation and differentiation in estrogen-responsive tissues. It is also involved in the metabolism of estrogens and can be formed through the hydroxylation of estrone by cytochrome P450 enzymes. The compound has garnered interest in research due to its potential implications in breast cancer and other hormone-related conditions. Its chemical formula is C18H22O3, and it has a specific molecular structure that allows it to interact with estrogen receptors. As with many steroid hormones, its levels in the body can be influenced by various factors, including age, health status, and environmental exposures.

Formula: C₁₈H₂₂O₃

InChI: InChI=1S/C18H22O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,19,21H,2-3,5,7-9H2,1H3/t11-,12-,14+,18+/m1/s1

InChI key: InChIKey=XQZVQQZZOVBNLU-QDTBLXIISA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=C(O)C(O)=CC4)(CC1)[H])[H])(CCC2=O)[H]

Synonyms:

• 3,4-Dihydroxy-1,3,5(10)-estratrien-17-one
• Estra-1,3,5(10)-trien-17-one, 3,4-dihydroxy-
• 3,4-Dihydroxyestra-1,3,5(10)-trien-17-one
• 4-Hydroxyestrone

(8R,9S,13S,14S)-3,4-Dihydroxy-13-methyl-7,8,9,11,12,13,15,16-octahydro-6H-cyclopenta[a]phenanthren-17(14H)-one

CAS: 3131-23-5

Formula: C₁₈H₂₂O₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 286.3655

Ref: IN-DA00C80X

4-Hydroxyestrone

CAS: 3131-23-5

4-Hydroxyestrone

Purity: 98%

Ref: 54-OR1037248

4-Hydroxy Estrone

Controlled Product

CAS: 3131-23-5

Formula: C₁₈H₂₂O₃

Color and Shape: Light Brown Solid

Molecular weight: 286.37

Ref: TR-H941950

4-Hydroxy estrone

Controlled Product

CAS: 3131-23-5

4-Hydroxy estrone is a metabolite of estrone. It has been shown to have genotoxic activity, which is thought to be due to its ability to form DNA adducts. 4-Hydroxy estrone has also been found to cause cancer in rat liver microsomes and body mass index in female rats. 4-Hydroxy estrone can be found in the environment as a result of wastewater treatment, where it reacts with triclosan and other compounds. 4-Hydroxy estrone has been shown to inhibit the activity of enzymes such as cytochrome P450 and aromatase that are involved in estrogen metabolism. Tumour necrosis factor-α (TNF-α) stimulates the production of this compound, which is thought to play an important role in the development of obesity-related cancers.

Formula: C₁₈H₂₂O₃

Purity: Min. 95%

Color and Shape: White To Yellow Or Light (Or Pale) Brown Solid

Molecular weight: 286.37 g/mol

Ref: 3D-FH23995

4-Hydroxy Estrone

CAS: 3131-23-5

Formula: C₁₈H₂₂O₃

Molecular weight: 286.37

Ref: ST-EA-CP-E28041

4-Hydroxyestrone

CAS: 3131-23-5

4-Hydroxyestrone, an endogenous estrogen metabolite, can strongly protect neuronal cells against oxidative damage.

Formula: C₁₈H₂₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 286.37

Ref: TM-T9454