CAS 313348-27-5

Regadenoson

Description:

Regadenoson is a pharmacological agent primarily used as a coronary vasodilator in medical imaging, particularly in stress testing for patients unable to undergo traditional exercise-based stress tests. It is a selective adenosine A2A receptor agonist, which means it binds to and activates these specific receptors, leading to vasodilation and increased blood flow in the coronary arteries. Regadenoson is characterized by its rapid onset of action and a relatively short half-life, making it suitable for use in clinical settings where quick diagnostic results are needed. The substance is typically administered intravenously and is known for its favorable safety profile, with fewer side effects compared to other stress agents. Its chemical structure includes a purine base, which is a common feature among adenosine derivatives. Regadenoson is marketed under various brand names and is an important tool in non-invasive cardiology for assessing myocardial perfusion.

Formula: C₁₅H₁₈N₈O₅

InChI: InChI=1S/C15H18N8O5/c1-17-13(27)6-2-19-23(3-6)15-20-11(16)8-12(21-15)22(5-18-8)14-10(26)9(25)7(4-24)28-14/h2-3,5,7,9-10,14,24-26H,4H2,1H3,(H,17,27)(H2,16,20,21)/t7-,9-,10-,14-/m1/s1

InChI key: InChIKey=LZPZPHGJDAGEJZ-AKAIJSEGSA-N

SMILES: NC1=C2C(N(C=N2)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)=NC(=N1)N4C=C(C(NC)=O)C=N4

Synonyms:

• 2-[4-(methylcarbamoyl)-1H-pyrazol-1-yl]adenosine
• 2-[4-[(Methylamino)carbonyl]-1H-pyrazol-1-yl]adenosine
• 6-Amino-2-[4-(methylcarbamoyl)-1H-pyrazol-1-yl]purine-9-yl-beta-D-ribofuranoside
• Adenosine, 2-[4-[(methylamino)carbonyl]-1H-pyrazol-1-yl]-
• Cv 3146
• Cvt-3146
• Lexiscan
• Nqz-021
• Rapiscan
• Regadenoson

Regadenoson

CAS: 313348-27-5

Formula: C₁₅H₁₈N₈O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 390.3540

Ref: IN-DA00C6LM

Regadenoson

CAS: 313348-27-5

Regadenoson

Purity: ≥98%

Molecular weight: 390.35g/mol

Ref: 54-BUP13124

Regadenoson

CAS: 313348-27-5

Formula: C₁₅H₁₈N₈O₅

Molecular weight: 390.35

Ref: 7W-GP4974

1-(6-Amino-9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)-9H-Purin-2-Yl)-N-Methyl-1H-Pyrazole-4-Carboxamide

CAS: 313348-27-5

1-(6-Amino-9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)-9H-Purin-2-Yl)-N-Methyl-1H-Pyrazole-4-Carboxamide

Purity: 99%

Molecular weight: 390.35g/mol

Ref: 54-OR1023981

Regadenoson

CAS: 313348-27-5

Formula: C₁₅H₁₈N₈O₅

Color and Shape: White To Off-White Solid

Molecular weight: 390.36

Ref: 4Z-R-095001

Regadenoson

CAS: 313348-27-5

Color and Shape: Neat

Ref: 86-MM3772.00

Regadenoson

CAS: 313348-27-5

Regadenoson (CVT-3146) is a selective A2A receptor agonist that increases coronary blood flow with a longer half-life than adenosine.

Formula: C₁₅H₁₈N₈O₅

Purity: 99.57% - 99.81%

Color and Shape: Off-White Solid

Molecular weight: 390.35

Ref: TM-T2671

Regadenoson

Controlled Product

CAS: 313348-27-5

Applications Regadenoson is a selective and potent A2A adenosine receptor agonist (1). The adenosine A2A receptor is a G-protein-coupled receptor and a key therapeutic target for oncologic, inflammatory, Parkinson's and cardiovascular diseases (2). In rodent studies, it has been shown that co-administration of Regadenoson with Temozolomide (T017775) can increase Temozolomide concentration in the brain (3).
References (1) Gao, Z., et al.: J Pharmacol Exp Ther. 298, 209 (2001) (2) Yuan, G., et al.: Expert Opin Drug Discov. 10, 63 (2015) (3) Jackson, S., et al.: J Neurooncol. 126, 433 (2016)

Formula: C₁₅H₁₈N₈O₅

Color and Shape: Off White

Molecular weight: 390.35

Ref: TR-R142800

Regadenoson

CAS: 313348-27-5

Adenosine-A2A receptor agonist

Formula: C₁₅H₁₈N₈O₅

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 390.36 g/mol

Ref: 3D-NR07283

Regadenoson-d3

Controlled Product

CAS: 313348-27-5

Applications A selective A2A adenosine receptor agonist in myocardial imaging.
References Palle, V.P., et al.: J. A. Drug Dev. Res., 50, 64 (2000), Gordi, T., et al.: J. Clin. Pharmacol., 47, 825 (2007), Zhao, G., et al.: J. Cardiovas. Pharmacol., 52, 467 (2008), Botvinick, E., et al.: J. Nuc. Med. Technol., 37, 14 (2009),

Formula: C₁₅H₁₅D₃N₈O₅

Color and Shape: Neat

Molecular weight: 393.37

Ref: TR-R142802