CAS 313516-66-4

2-Chloro-5-nitro-N-4-pyridinylbenzamide

Description:

2-Chloro-5-nitro-N-4-pyridinylbenzamide, with the CAS number 313516-66-4, is a chemical compound characterized by its complex structure, which includes a benzamide moiety substituted with a chloro and a nitro group, as well as a pyridinyl group. This compound typically exhibits properties associated with both aromatic and heterocyclic compounds, including potential solubility in organic solvents and moderate stability under standard conditions. The presence of the nitro group often imparts significant reactivity, making it a candidate for various chemical reactions, including nucleophilic substitutions. Additionally, the chloro substituent can influence the compound's electronic properties and reactivity. This compound may be of interest in pharmaceutical research due to its potential biological activity, particularly in the development of new therapeutic agents. Its specific applications and interactions would depend on further studies, including its behavior in biological systems and its efficacy in targeted applications. As with all chemical substances, proper handling and safety measures should be observed due to potential hazards associated with its components.

Formula: C₁₂H₈ClN₃O₃

InChI: InChI=1S/C12H8ClN3O3/c13-11-2-1-9(16(18)19)7-10(11)12(17)15-8-3-5-14-6-4-8/h1-7H,(H,14,15,17)

InChI key: InChIKey=FRPJSHKMZHWJBE-UHFFFAOYSA-N

SMILES: C(NC=1C=CN=CC1)(=O)C2=CC(N(=O)=O)=CC=C2Cl

Synonyms:

• 2-Chloro-5-nitro-N-4-pyridinylbenzamide
• 2-chloro-5-nitro-N-pyridin-4-ylbenzamide
• Benzamide, 2-chloro-5-nitro-N-4-pyridinyl-
• T-0070907
• T0070907

T0070907

CAS: 313516-66-4

Formula: C₁₂H₈ClN₃O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 277.6632

Ref: IN-DA00C0BR

T0070907

CAS: 313516-66-4

Formula: C₁₂H₈ClN₃O₃

Purity: (HPLC) ≥ 99.0%

Color and Shape: White solid

Molecular weight: 277.66

Ref: 7W-GL3830

N1-(4-pyridyl)-2-chloro-5-nitrobenzamide

CAS: 313516-66-4

N1-(4-pyridyl)-2-chloro-5-nitrobenzamide

Formula: C₁₂H₈ClN₃O₃

Purity: 98%

Color and Shape: pale yellow solid

Molecular weight: 277.66322g/mol

Ref: 54-OR24163

T0070907

CAS: 313516-66-4

T0070907

Purity: ≥98%

Molecular weight: 277.66g/mol

Ref: 54-BUP15544

T 0070907

CAS: 313516-66-4

Formula: C₁₂H₈ClN₃O₃

Purity: >95.0%(T)(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 277.66

Ref: 3B-T4283

T0070907

CAS: 313516-66-4

T0070907(IC50=1 nM) , an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ.

Formula: C₁₂H₈ClN₃O₃

Purity: 98.25% - 99.98%

Color and Shape: Solid

Molecular weight: 277.66

Ref: TM-T6689

2-Chloro-5-nitro-N-4-pyridinylbenzamide

Controlled Product

CAS: 313516-66-4

Applications A cell-permeable chloro-nitro-benzamido compound that acts as a potent, specific, irreversible, and high-affinity antagonist of PPARγ with a Ki of 1 nM. Displays >800-fold greater selectivity for PPARγ over PPARα and PPARδ (Ki = 0.85 µM and 1.8 µM, respectively). Blocks hormone- and agonist-induced adipogenesis in 3T3-L1 cells. It suppresses interactions between PPARγ and coactivator-derived peptides, while promotes the recruitment of corepressor-derived peptides. Shown to modulate the interaction of PPARγ2 with the cofactor proteins through covalent binding to Cys313 in its ligand-binding domain.
References Lee, G., et al: J. Biol. Chem., 277, 19649 (2003), Schaefer, K.L., et al: Cancer Res., 65, 2251 (2005), Masuda, T., et al.: Clin. Cancer Res., 11, 4012 (2005), Raikwar, H.P., et al.: J. Neuroimmunol., 167, 99 (2005)

Formula: C₁₂H₈ClN₃O₃

Color and Shape: Neat

Molecular weight: 277.66

Ref: TR-C374760

2-Chloro-5-nitro-N-4-pyridinylbenzamide

CAS: 313516-66-4

Formula: C₁₂H₈ClN₃O₃

Purity: 99%

Molecular weight: 277.66

Ref: 10-F092557

T 0070907

CAS: 313516-66-4

PPARγ antagonist

Formula: C₁₂H₈ClN₃O₃

Purity: Min. 95%

Molecular weight: 277.66 g/mol

Ref: 3D-FC20133