CAS 313516-66-4
:2-Chloro-5-nitro-N-4-pyridinylbenzamide
Description:
2-Chloro-5-nitro-N-4-pyridinylbenzamide, with the CAS number 313516-66-4, is a chemical compound characterized by its complex structure, which includes a benzamide moiety substituted with a chloro and a nitro group, as well as a pyridinyl group. This compound typically exhibits properties associated with both aromatic and heterocyclic compounds, including potential solubility in organic solvents and moderate stability under standard conditions. The presence of the nitro group often imparts significant reactivity, making it a candidate for various chemical reactions, including nucleophilic substitutions. Additionally, the chloro substituent can influence the compound's electronic properties and reactivity. This compound may be of interest in pharmaceutical research due to its potential biological activity, particularly in the development of new therapeutic agents. Its specific applications and interactions would depend on further studies, including its behavior in biological systems and its efficacy in targeted applications. As with all chemical substances, proper handling and safety measures should be observed due to potential hazards associated with its components.
Formula:C12H8ClN3O3
InChI:InChI=1S/C12H8ClN3O3/c13-11-2-1-9(16(18)19)7-10(11)12(17)15-8-3-5-14-6-4-8/h1-7H,(H,14,15,17)
InChI key:InChIKey=FRPJSHKMZHWJBE-UHFFFAOYSA-N
SMILES:C(NC=1C=CN=CC1)(=O)C2=CC(N(=O)=O)=CC=C2Cl
Synonyms:- 2-Chloro-5-nitro-N-4-pyridinylbenzamide
- 2-chloro-5-nitro-N-pyridin-4-ylbenzamide
- Benzamide, 2-chloro-5-nitro-N-4-pyridinyl-
- T-0070907
- T0070907
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Found 9 products.
T0070907
CAS:Formula:C12H8ClN3O3Purity:(HPLC) ≥ 99.0%Color and Shape:White solidMolecular weight:277.66N1-(4-pyridyl)-2-chloro-5-nitrobenzamide
CAS:<p>N1-(4-pyridyl)-2-chloro-5-nitrobenzamide</p>Formula:C12H8ClN3O3Purity:98%Color and Shape: pale yellow solidMolecular weight:277.66322g/molT 0070907
CAS:Formula:C12H8ClN3O3Purity:>95.0%(T)(HPLC)Color and Shape:White to Light yellow to Light orange powder to crystalMolecular weight:277.66T0070907
CAS:<p>T0070907(IC50=1 nM) , an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ.</p>Formula:C12H8ClN3O3Purity:98.25% - 99.98%Color and Shape:SolidMolecular weight:277.662-Chloro-5-nitro-N-4-pyridinylbenzamide
CAS:Controlled Product<p>Applications A cell-permeable chloro-nitro-benzamido compound that acts as a potent, specific, irreversible, and high-affinity antagonist of PPARγ with a Ki of 1 nM. Displays >800-fold greater selectivity for PPARγ over PPARα and PPARδ (Ki = 0.85 µM and 1.8 µM, respectively). Blocks hormone- and agonist-induced adipogenesis in 3T3-L1 cells. It suppresses interactions between PPARγ and coactivator-derived peptides, while promotes the recruitment of corepressor-derived peptides. Shown to modulate the interaction of PPARγ2 with the cofactor proteins through covalent binding to Cys313 in its ligand-binding domain.<br>References Lee, G., et al: J. Biol. Chem., 277, 19649 (2003), Schaefer, K.L., et al: Cancer Res., 65, 2251 (2005), Masuda, T., et al.: Clin. Cancer Res., 11, 4012 (2005), Raikwar, H.P., et al.: J. Neuroimmunol., 167, 99 (2005)<br></p>Formula:C12H8ClN3O3Color and Shape:NeatMolecular weight:277.66T 0070907
CAS:<p>PPARγ antagonist</p>Formula:C12H8ClN3O3Purity:Min. 95%Molecular weight:277.66 g/mol
