CAS 313682-08-5

Brecanavir

Description:

Brecanavir is an experimental antiviral compound that belongs to the class of protease inhibitors, primarily investigated for its potential use in the treatment of HIV. It functions by inhibiting the HIV protease enzyme, which is crucial for the viral replication process. Brecanavir is characterized by its specific molecular structure, which includes various functional groups that contribute to its biological activity. The compound has been studied for its efficacy and safety profile in clinical settings, although it has not received widespread approval for clinical use. Its pharmacokinetic properties, such as absorption, distribution, metabolism, and excretion, are essential for understanding its therapeutic potential and dosing regimens. Additionally, like many antiviral agents, Brecanavir may exhibit side effects and interactions with other medications, necessitating careful consideration in treatment plans. Research continues to explore its effectiveness and potential role in combination therapies for HIV management.

Formula: C₃₃H₄₁N₃O₁₀S₂

InChI: InChI=1S/C33H41N3O10S2/c1-20(2)14-36(48(39,40)25-8-9-29-30(13-25)45-19-44-29)15-28(37)27(35-33(38)46-31-17-43-32-26(31)10-11-41-32)12-22-4-6-24(7-5-22)42-16-23-18-47-21(3)34-23/h4-9,13,18,20,26-28,31-32,37H,10-12,14-17,19H2,1-3H3,(H,35,38)/t26-,27-,28+,31-,32+/m0/s1

InChI key: InChIKey=JORVRJNILJXMMG-OLNQLETPSA-N

SMILES: O(C(N[C@@H](CC1=CC=C(OCC=2N=C(C)SC2)C=C1)[C@@H](CN(S(=O)(=O)C=3C=C4C(=CC3)OCO4)CC(C)C)O)=O)[C@@H]5[C@]6([C@@](OC5)(OCC6)[H])[H]

Synonyms:

• Brecanavir
• GW 0385
• GW 64085X
• Carbamic acid, N-[(1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-[[4-[(2-methyl-4-thiazolyl)methoxy]phenyl]methyl]propyl]-, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester
• Carbamic acid, [(1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-[[4-[(2-methyl-4-thiazolyl)methoxy]phenyl]methyl]propyl]-, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester

Brecanavir

CAS: 313682-08-5

Brecanavir is a tyrosyl-based arylsulfonamide, high affinity, protease inhibitor (PI) for the treatment of human immunodeficiency virus type 1.

Formula: C₃₃H₄₁N₃O₁₀S₂

Color and Shape: Solid

Molecular weight: 703.82

Ref: TM-T30585