CAS 31373-65-6

Hippuryl-L-histidyl-L-leucine

Description:

Hippuryl-L-histidyl-L-leucine, identified by its CAS number 31373-65-6, is a dipeptide derivative that consists of the amino acids histidine and leucine linked by a peptide bond to a hippuric acid moiety. This compound exhibits characteristics typical of peptides, including the ability to participate in various biochemical reactions and interactions due to its functional groups. It is likely to be soluble in polar solvents, such as water, owing to the presence of amino and carboxyl groups that can engage in hydrogen bonding. The presence of histidine contributes to its potential buffering capacity, while leucine may enhance hydrophobic interactions. Hippuryl-L-histidyl-L-leucine may have applications in biochemical research, particularly in studies related to peptide synthesis, protein interactions, and metabolic pathways. Its stability and reactivity can be influenced by environmental factors such as pH and temperature, which are critical for its behavior in biological systems. Overall, this compound represents a fascinating area of study within peptide chemistry and biochemistry.

Formula: C₂₁H₂₇N₅O₅

InChI: InChI=1S/C21H27N5O5/c1-13(2)8-17(21(30)31)26-20(29)16(9-15-10-22-12-24-15)25-18(27)11-23-19(28)14-6-4-3-5-7-14/h3-7,10,12-13,16-17H,8-9,11H2,1-2H3,(H,22,24)(H,23,28)(H,25,27)(H,26,29)(H,30,31)/t16-,17-/m0/s1

InChI key: InChIKey=AAXWBCKQYLBQKY-IRXDYDNUSA-N

SMILES: [C@H](CC1=CN=CN1)(C(N[C@@H](CC(C)C)C(O)=O)=O)NC(CNC(=O)C2=CC=CC=C2)=O

Synonyms:

• <span class="text-smallcaps">L</smallcap>-Leucine, N-[N-(N-benzoylglycyl)-<smallcap>L</span>-histidyl]-
• <span class="text-smallcaps">L</smallcap>-Leucine, N-benzoylglycyl-<smallcap>L</span>-histidyl-
• Hippuryl-<span class="text-smallcaps">L</smallcap>-histidyl-<smallcap>L</span>-leucine
• Hippuryl-His-Leu
• Leucine, N-(N-hippuroyl-<span class="text-smallcaps">L</smallcap>-histidyl)-, <smallcap>L</span>-
• N-Benzoylglycyl-<span class="text-smallcaps">L</smallcap>-histidyl-<smallcap>L</span>-leucine
• N-Benzoylglycyl-L-histidyl-L-leucine
• Hippuryl-L-histidyl-L-leucine
• L-Leucine, N-benzoylglycyl-L-histidyl-
• L-Leucine, N-[N-(N-benzoylglycyl)-L-histidyl]-
• Leucine, N-(N-hippuroyl-L-histidyl)-, L-

Hippuryl-His-Leu-OH

CAS: 31373-65-6

Substrate for a spectrophotometric assay of angiotensin I-converting enzyme. ACE cleavage of Hip-His-Leu yields hippuric acid and His-Leu (G-2310), which can be quantified by generating a fluorescent adduct with o-phthalaldehyde. Schwager et al. developed a high-throughput fluorometric assay for ACE employing Hip-His-Leu.

Formula: C₂₁H₂₇N₅O₅

Purity: ≥ 99%

Color and Shape: White Lyophilisate

Molecular weight: 429.48

Ref: 01-4002147

Hippuryl-his-leu-oh

CAS: 31373-65-6

Formula: C₂₁H₂₇N₅O₅

Purity: 98%

Molecular weight: 429.4696

Ref: IN-DA007JNH

(S)-2-((S)-2-(2-Benzamidoacetamido)-3-(1H-imidazol-4-yl)propanamido)-4-methylpentanoic acid

CAS: 31373-65-6

(S)-2-((S)-2-(2-Benzamidoacetamido)-3-(1H-imidazol-4-yl)propanamido)-4-methylpentanoic acid

Purity: 98%

Molecular weight: 429.48g/mol

Ref: 54-OR1073976

Hippuryl-His-Leu-OH

CAS: 31373-65-6

Hippuryl-His-Leu-OH tests for angiotensin I enzyme activity, allowing His-Leu detection by fluorescence.

Formula: C₂₁H₂₇N₅O₅

Color and Shape: Solid

Molecular weight: 429.47

Ref: TM-T76610

Bz-Gly-His-Leu • H2O [Hippuryl-Histidyl-Leucine]

CAS: 31373-65-6

Bz-Gly-His-Leu is a peptide that has the amino acid sequence of Hippuryl-Histidyl-Leucine. The peptide binds to Angiotensin I Converting Enzyme I Substrates and prevents the enzyme from converting Angiotensin I to Angiotensin II, thereby lowering blood pressure. Bz-Gly-His-Leu has been shown to be effective in reducing blood pressure in patients with congestive heart failure as well as those with normal cardiac function.

Formula: C₂₁H₂₇N₅O₅•H₂O

Purity: Min. 95%

Molecular weight: 447.49 g/mol

Ref: 3D-SGL-3064

Hippuryl-His-Leu-OH

CAS: 31373-65-6

Hippuryl-His-Leu-OH is a peptide that inhibits the activity of angiotensin converting enzyme (ACE) at a concentration of 50 μM. It has been shown to inhibit cyclase and other enzymes in vitro. The binding of this compound to ACE prevents the conversion of angiotensin I to angiotensin II, which is a potent vasoconstrictor. Hippuryl-His-Leu-OH also has inhibitory properties against atrial natriuretic peptide (ANP), and can be used as an antihypertensive agent. This drug has been shown to have growth factor β1 activities, and can be used for the treatment of cardiac diseases such as myocardial infarction. Structural analysis shows that this drug binds to the active site of ACE, inhibiting its activity by blocking access to substrate or by altering substrate specificity.

Formula: C₂₁H₂₇N₅O₅

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 429.47 g/mol

Ref: 3D-FH110864