CAS 314-50-1

Orotidine

Description:

Orotidine, also known as orotidine monophosphate (OMP), is a pyrimidine nucleotide that plays a crucial role in the biosynthesis of nucleic acids. It is characterized by its molecular formula, which includes carbon, hydrogen, nitrogen, and oxygen atoms. Orotidine is a key intermediate in the de novo synthesis pathway of pyrimidine nucleotides, specifically in the conversion of orotic acid to uridine monophosphate (UMP). This compound is soluble in water and exhibits a relatively low molecular weight. Orotidine is involved in various biological processes, including RNA synthesis and cellular metabolism. Its structure features a pyrimidine ring, which is essential for its function in nucleotide synthesis. Additionally, orotidine can be phosphorylated to form orotidine-5'-monophosphate, which is further converted into other nucleotides. Due to its role in nucleotide metabolism, orotidine and its derivatives are of interest in pharmacology and biochemistry, particularly in the study of metabolic disorders and potential therapeutic applications.

Formula: C₁₀H₁₂N₂O₈

InChI: InChI=1S/C10H12N2O8/c13-2-4-6(15)7(16)8(20-4)12-3(9(17)18)1-5(14)11-10(12)19/h1,4,6-8,13,15-16H,2H2,(H,17,18)(H,11,14,19)/t4-,6-,7-,8-/m1/s1

InChI key: InChIKey=FKCRAVPPBFWEJD-XVFCMESISA-N

SMILES: C(O)(=O)C=1N(C(=O)NC(=O)C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O

Synonyms:

• 1,2,3,6-Tetrahydro-2,6-dioxo-3-β-<span class="text-smallcaps">D</span>-ribofuranosyl-4-pyrimidinecarboxylic acid
• 3-Ribofuranosylorotic acid
• 4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-3-beta-D-ribofuranosyl-
• 4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-3-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• 6-Carboxyuridine
• Orotic acid riboside
• Orotidine
• 1,2,3,6-Tetrahydro-2,6-dioxo-3-β-D-ribofuranosyl-4-pyrimidinecarboxylic acid
• 4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-3-β-D-ribofuranosyl-

4-Pyrimidinecarboxylicacid, 1,2,3,6-tetrahydro-2,6-dioxo-3-b-D-ribofuranosyl-

CAS: 314-50-1

Formula: C₁₀H₁₂N₂O₈

Purity: 90%

Color and Shape: Solid

Molecular weight: 288.2109

Ref: IN-DA007JEX

Orotidine

CAS: 314-50-1

Formula: C₁₀H₁₂N₂O₈

Purity: ≥ 90.0%

Color and Shape: Off-white to red powder

Molecular weight: 288.21

Ref: 7W-GN7952

Orotidine

CAS: 314-50-1

Orotidine (Uridin-6-carboxylic acid) is a nucleoside found in bacteria, fungi, and plants. In humans, orotidine occurs as its 5'-phosphate (orotidylic acid).

Formula: C₁₀H₁₂N₂O₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 288.21

Ref: TM-TQ0148

Orotidine

CAS: 314-50-1

Formula: C₁₀H₁₂N₂O₈

Molecular weight: 288.21

Ref: 4Z-O-132001

Orotidine

CAS: 314-50-1

Applications Orotidine is a metabolite of Orotic Acid (O691500); a compound used in the preparation of therapeutic agents for chronic obstructive pulmonary disease (COPD) treatment.
References Pausch, J., et al.: Verhandlungen der Deutschen Gesellschaft fuer Innere Medizin, 86, 805 (1980); Burgess, K., et al.: Rapid Commun. Mass. Sp., 25, 3447 (2011)

Formula: C₁₀H₁₂N₂O₈

Color and Shape: Neat

Molecular weight: 288.21

Ref: TR-O691520

Orotidine

CAS: 314-50-1

Orotidine is a decarboxylase inhibitor. It inhibits the enzyme that converts orotate to uridine and the enzyme that converts orotate to decarboxylase. Orotidine has been shown to inhibit the growth of opportunistic fungal organisms and may be useful in treating infections caused by these pathogens. Orotidine is an analytical method for measuring the activity of orotidase, which catalyzes conversion of orotate to uridine. The enzyme form of orotidase found in human erythrocytes is very sensitive to inhibition by picolinic acid, which is used as a substrate for this reaction.

Formula: C₁₀H₁₂N₂O₈

Purity: Min. 95 Area-%

Color and Shape: White Powder

Molecular weight: 288.21 g/mol

Ref: 3D-NO08048

Orotidine

CAS: 314-50-1

Formula: C₁₀H₁₂N₂O₈

Molecular weight: 288.21

Ref: ST-EA-CP-O38022