CAS 31430-18-9: Nocodazole

Description: Nocodazole is a synthetic chemical compound primarily used in research as a microtubule-disrupting agent. It is classified as a benzimidazole derivative and is known for its ability to inhibit cell division by interfering with the polymerization of tubulin, which is essential for microtubule formation. This disruption leads to cell cycle arrest, particularly in the mitotic phase, making nocodazole a valuable tool in studies of cell biology and cancer research. The compound is typically administered in a powdered form and is soluble in organic solvents such as dimethyl sulfoxide (DMSO) but has limited solubility in water. Nocodazole has been shown to induce various cellular responses, including apoptosis, and is often used in experiments to investigate the mechanisms of drug resistance and the effects of cytoskeletal alterations on cellular functions. While it has significant research applications, nocodazole's use is primarily confined to laboratory settings due to its potential toxicity and the need for careful handling.

Formula: C₁₄H₁₁N₃O₃S

InChI: InChI=1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)

InChI key: InChIKey=KYRVNWMVYQXFEU-UHFFFAOYSA-N

SMILES: O=C(OC)NC1=NC=2C=CC(=CC2N1)C(=O)C=3SC=CC3

Synonyms:

• 2-Benzimidazolecarbamic acid, 5-(2-thenoyl)-, methyl ester
• Carbamic acid, N-[6-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-, methyl ester
• Carbamic acid, [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-, methyl ester
• Methyl[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamate
• N-[5-(2-Thenoyl)-2-benzimidazolyl]carbamic acid methyl ester
• NSC 238159
• Oncodazole
• R 17934
• [5-(Thiophene-2-carbonyl)-1H-benzoimidazol-2-yl]-carbamic acid methyl ester
• [6-(Thiophene-2-carbonyl)-1H-benzoimidazol-2-yl]-carbamic acid methyl ester
• methyl [6-(thiophen-2-ylcarbonyl)-1H-benzimidazol-2-yl]carbamate

NOCODAZOLE

CAS: 31430-18-9

• Formula: C₁₄H₁₁N₃O₃S
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 301.3204

Nocodazole

CAS: 31430-18-9

• Purity: 99.33%
• Molecular weight: 301.32g/mol

Nocodazole

CAS: 31430-18-9

• Purity: 98%
• Molecular weight: 301.32g/mol

Nocodazole, 98%

CAS: 31430-18-9

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Formula: C₁₄H₁₁N₃O₃S
• Purity: 98%
• Color and Shape: White to orange-brown, Powder
• Molecular weight: 301.32

Nocodazole

CAS: 31430-18-9

Nocodazole: synthetic microtubule polymerization blocker, also impedes Abl with low IC50; binds to beta-tubulin.

• Formula: C₁₄H₁₁N₃O₃S
• Purity: 98% - 99.91%
• Color and Shape: Physical Description White Powder (Ntp 1992)
• Molecular weight: 301.32

Nocodazole

CAS: 31430-18-9

• Formula: C₁₄H₁₁N₃O₃S
• Purity: ≥ 98%
• Color and Shape: White to pale yellow powder
• Molecular weight: 301.32

Nocodazole

CAS: 31430-18-9

M05733 - Nocodazole

• Formula: C₁₄H₁₁N₃O₃S
• Purity: 98%
• Color and Shape: Solid, Beige powder
• Molecular weight: 301.32000732421875

Nocodazole

CAS: 31430-18-9

Anti-microtubular agent; antineoplastic

• Formula: C₁₄H₁₁N₃O₃S
• Purity: Min. 95%
• Color and Shape: Off-White To Yellow Solid
• Molecular weight: 301.32 g/mol

Nocodazole

CAS: 31430-18-9

• Formula: C₁₄H₁₁N₃O₃S
• Purity: >98.0%(HPLC)
• Color and Shape: White to Orange to Green powder to crystal
• Molecular weight: 301.32

Methyl-(5-[2-thienylcarbonyl]-1H-benzimidazol-2yl)carbamate

CAS: 31430-18-9

• Formula: C₁₄H₁₁N₃O₃S
• Color and Shape: Neat
• Molecular weight: 301.32