CAS 31430-18-9

Nocodazole

Description:

Nocodazole is a synthetic chemical compound primarily used in research as a microtubule-disrupting agent. It is classified as a benzimidazole derivative and is known for its ability to inhibit cell division by interfering with the polymerization of tubulin, which is essential for microtubule formation. This disruption leads to cell cycle arrest, particularly in the mitotic phase, making nocodazole a valuable tool in studies of cell biology and cancer research. The compound is typically administered in a powdered form and is soluble in organic solvents such as dimethyl sulfoxide (DMSO) but has limited solubility in water. Nocodazole has been shown to induce various cellular responses, including apoptosis, and is often used in experiments to investigate the mechanisms of drug resistance and the effects of cytoskeletal alterations on cellular functions. While it has significant research applications, nocodazole's use is primarily confined to laboratory settings due to its potential toxicity and the need for careful handling.

Formula: C₁₄H₁₁N₃O₃S

InChI: InChI=1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)

InChI key: InChIKey=KYRVNWMVYQXFEU-UHFFFAOYSA-N

SMILES: C(=O)(C=1C=C2C(N=C(NC(OC)=O)N2)=CC1)C3=CC=CS3

Synonyms:

• 2-Benzimidazolecarbamic acid, 5-(2-thenoyl)-, methyl ester
• Carbamic acid, N-[6-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-, methyl ester
• Carbamic acid, [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-, methyl ester
• Methyl[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamate
• N-[5-(2-Thenoyl)-2-benzimidazolyl]carbamic acid methyl ester
• NSC 238159
• Oncodazole
• R 17934
• [5-(Thiophene-2-carbonyl)-1H-benzoimidazol-2-yl]-carbamic acid methyl ester
• [6-(Thiophene-2-carbonyl)-1H-benzoimidazol-2-yl]-carbamic acid methyl ester
• methyl [6-(thiophen-2-ylcarbonyl)-1H-benzimidazol-2-yl]carbamate

Nocodazole

CAS: 31430-18-9

Formula: C₁₄H₁₁N₃O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 301.3204

Ref: IN-DA00BXYX

Nocodazole

CAS: 31430-18-9

Nocodazole

Purity: 98%

Molecular weight: 301.32g/mol

Ref: 54-OR1026370

Nocodazole

CAS: 31430-18-9

Nocodazole

Purity: ≥98%

Molecular weight: 301.32g/mol

Ref: 54-BUP13407

Nocodazole

CAS: 31430-18-9

Formula: C₁₄H₁₁N₃O₃S

Purity: >98.0%(HPLC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 301.32

Ref: 3B-N1138

Nocodazole

CAS: 31430-18-9

Nocodazole: synthetic microtubule polymerization blocker, also impedes Abl with low IC50; binds to beta-tubulin.

Formula: C₁₄H₁₁N₃O₃S

Purity: 98% - 99.91%

Color and Shape: Physical Description White Powder (Ntp 1992)

Molecular weight: 301.32

Ref: TM-T2802

Nocodazole

CAS: 31430-18-9

Formula: C₁₄H₁₁N₃O₃S

Molecular weight: 301.32

Ref: 4Z-N-188001

Nocodazole

CAS: 31430-18-9

Formula: C₁₄H₁₁N₃O₃S

Purity: ≥ 98%

Color and Shape: White to pale yellow powder

Molecular weight: 301.32

Ref: 7W-GP8428

Nocodazole

CAS: 31430-18-9

M05733 - Nocodazole

Formula: C₁₄H₁₁N₃O₃S

Purity: 98%

Color and Shape: Solid, Beige powder

Molecular weight: 301.32000732421875

Ref: 10-M05733

Nocodazole

CAS: 31430-18-9

Anti-microtubular agent; antineoplastic

Formula: C₁₄H₁₁N₃O₃S

Purity: Min. 95%

Color and Shape: Off-White To Yellow Solid

Molecular weight: 301.32 g/mol

Ref: 3D-FN12330

Methyl-(5-[2-thienylcarbonyl]-1H-benzimidazol-2yl)carbamate

Controlled Product

CAS: 31430-18-9

Formula: C₁₄H₁₁N₃O₃S

Color and Shape: Neat

Molecular weight: 301.32

Ref: TR-M330350