4-Iodopyrimidine is a heterocyclic organic compound characterized by a pyrimidine ring substituted with an iodine atom at the 4-position. Its molecular formula is C4H3I N2, indicating the presence of carbon, hydrogen, nitrogen, and iodine. This compound typically appears as a white to light yellow crystalline solid and is known for its role in organic synthesis, particularly in the development of pharmaceuticals and agrochemicals. The iodine substituent enhances its reactivity, making it a useful intermediate in various chemical reactions, including nucleophilic substitutions and coupling reactions. 4-Iodopyrimidine is soluble in polar organic solvents, and its reactivity can be attributed to the electron-withdrawing nature of the iodine atom, which influences the electronic properties of the pyrimidine ring. Additionally, it may exhibit biological activity, making it of interest in medicinal chemistry. Proper handling and storage are essential due to the potential hazards associated with iodine-containing compounds.

4-Iodopyrimidine

31462-57-4: 4-Iodopyrimidine is a heterocyclic organic compound characterized by a pyrimidine ring substituted with an iodine atom at the 4-position. Its molecular formula is C4H3I N2, indicating the presence of carbon, hydrogen, nitrogen, and iodine. This compound typically appears as a white to light yellow crystalline solid and is known for its role in organic synthesis, particularly in the development of pharmaceuticals and agrochemicals. The iodine substituent enhances its reactivity, making it a useful intermediate in various chemical reactions, including nucleophilic substitutions and coupling reactions. 4-Iodopyrimidine is soluble in polar organic solvents, and its reactivity can be attributed to the electron-withdrawing nature of the iodine atom, which influences the electronic properties of the pyrimidine ring. Additionally, it may exhibit biological activity, making it of interest in medicinal chemistry. Proper handling and storage are essential due to the potential hazards associated with iodine-containing compounds.

<p>Applications 4-Iodopyrimidine is used as a reactant in the preparation of 1,3,8-triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia.<br>References Vachal, P., et. al.: J. Med. Chem., 55, 2945 (2012)<br></p>

CAS 31462-57-4

4-Iodopyrimidine

4-Iodopyrimidine

Ref: IN-DA00CL02

4-Iodopyrimidine

Ref: TR-I719505