CAS 314771-88-5

N-(3-Chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4-quinazolinamine

Description:

N-(3-Chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4-quinazolinamine, with the CAS number 314771-88-5, is a synthetic organic compound characterized by its complex molecular structure, which includes a quinazolinamine core. This compound features multiple functional groups, including a nitro group, a chloro group, and a fluorine atom, contributing to its potential biological activity. The presence of the tetrahydro-3-furanyl moiety suggests that it may exhibit interesting pharmacological properties, possibly related to its interactions with biological targets. The compound's solubility, stability, and reactivity can be influenced by its substituents, making it a candidate for further investigation in medicinal chemistry. Its specific applications may include roles in drug development, particularly in targeting certain diseases or conditions, although detailed studies would be necessary to elucidate its efficacy and safety profile. As with many synthetic compounds, proper handling and safety measures should be observed due to potential toxicity or reactivity.

Formula: C₁₈H₁₄ClFN₄O₄

InChI: InChI=1S/C18H14ClFN4O4/c19-13-5-10(1-2-14(13)20)23-18-12-6-16(24(25)26)17(7-15(12)21-9-22-18)28-11-3-4-27-8-11/h1-2,5-7,9,11H,3-4,8H2,(H,21,22,23)/t11-/m0/s1

InChI key: InChIKey=UXAZURVGMXJLSO-NSHDSACASA-N

SMILES: N(C=1C2=C(C=C(O[C@H]3CCOC3)C(N(=O)=O)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4

Synonyms:

• (S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine
• (S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine
• 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-
• N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4-quinazolinamine
• 7-((S)-tetrahydrofuran-3-yloxy)-4-(3-chloro-4-fluorophenyl)aMino-6-nitroquinazoline
• 7-((S)-tetrahydrofuran-3-yloxy)-4-(3-chloro-4-fluorophenyl)a...
• Afatinib intermediate C
• 7-((S)-tetrahydrofuran-3-yloxy) -N-(3-chloro-4-fluorophenyl) -6-nitroquinazolin-4-amine
• N-(3-chloro-4-fluorophenyl)-6-nitro-7-[(3S)-oxolan-3-yl]oxyquinazolin-4-amine
• N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-
• N-(3-chloro-4-fluorophenyl)-6-nitro-7-[(3S)-oxolan-3-yl]oxyquinazolin-

4-QuinazolinaMine,N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-

CAS: 314771-88-5

Formula: C₁₈H₁₄ClFN₄O₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 404.7796

Ref: IN-DA00I5YH

(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine

CAS: 314771-88-5

(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine

Purity: 97%

Molecular weight: 404.79g/mol

Ref: 54-PC1007865

Afatinib Impurity 47

CAS: 314771-88-5

Formula: C₁₈H₁₄ClFN₄O₄

Color and Shape: Yellow Solid

Molecular weight: 404.78

Ref: 4Z-A-111064

(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine

Controlled Product

CAS: 314771-88-5

Applications (S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine is a used in the synthetic preparation of 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of epidermal growth factor receptor. It is also used in the preparation of (2Z)-Afatinib (A355305) which is used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.
References Zhang, X., et al.: Bioorg. Med. Chem., 21, 7988 (2013); Ermoli, A. et al.: J. Med. Chem., 52, 4380 (2009); Pearson, S. et al.: Synthesis, 15, 2503 (2005);

Formula: C₁₈H₁₄ClFN₄O₄

Color and Shape: Neat

Molecular weight: 404.78

Ref: TR-C367720

(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine

CAS: 314771-88-5

Purity: 97%

Molecular weight: 404.7799988

Ref: 10-F788953

Afatinib Impurity 26

CAS: 314771-88-5

Formula: C₁₈H₁₄ClFN₄O₄

Molecular weight: 404.78

Ref: ST-EA-CP-A50040