CAS 316-42-7

Emetine hydrochloride

Description:

Emetine hydrochloride is a chemical compound that belongs to the class of alkaloids, specifically derived from the plant Cephaelis ipecacuanha, commonly known as ipecac. It is characterized by its white to off-white crystalline appearance and is soluble in water and alcohol. Emetine hydrochloride is primarily known for its emetic properties, meaning it can induce vomiting, and has historically been used in the treatment of amoebic dysentery. Additionally, it exhibits antiprotozoal and anti-inflammatory effects, making it of interest in various therapeutic applications. The compound acts by inhibiting protein synthesis in cells, which contributes to its pharmacological effects. However, due to its potential toxicity and side effects, its use has become limited, and it is often replaced by safer alternatives in clinical settings. As with many alkaloids, careful handling and dosage are crucial to avoid adverse reactions. Overall, emetine hydrochloride is a significant compound in pharmacology, with a rich history in medicinal use.

Formula: C₂₉H₄₀N₂O₄·2ClH

InChI: InChI=1S/C29H40N2O4.2ClH/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24;;/h13-16,18,21,24-25,30H,6-12,17H2,1-5H3;2*1H/t18-,21-,24+,25-;;/m0../s1

InChI key: InChIKey=JROGBPMEKVAPEH-GXGBFOEMSA-N

SMILES: C([C@H]1C[C@]2(C=3C(=CC(OC)=C(OC)C3)CCN2C[C@@H]1CC)[H])[C@@H]4C=5C(=CC(OC)=C(OC)C5)CCN4.Cl

Synonyms:

• (1'Xi,14Xi)-6',7',10,11-Tetramethoxyemetan Dihydrochloride
• 2H-Benzo[a]quinolizine, 3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2-[(1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolyl)methyl]-, dihydrochloride
• 2H-Benzo[a]quinolizine, 3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl]methyl]-, dihydrochloride, (2S,3R,11bS)-
• 2H-Benzo[a]quinolizine, 3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl]methyl]-, hydrochloride (1:2), (2S,3R,11bS)-
• 6',7',10,11-Tetramethoxyemetan
• 6',7',10,11-Tetramethoxyemetan Dihydrochloride
• Emetan, 6′,7′,10,11-tetramethoxy-, dihydrochloride
• Emetine Dihydrochloride
• Emetine hydrochloride
• Emetine, DiHCl
• Hemometina
• Hydrogen Chloride 6',7',10,11-Tetramethoxyemetan (1:1:1)

Emetine Dihydrochloride

CAS: 316-42-7

Color and Shape: Neat

Ref: 61-FOR0131.02

EMETINE HYDROCHLORIDE RS

CAS: 316-42-7

EMETINE HYDROCHLORIDE RS

Formula: C₂₉H₄₂Cl₂N₂O₄

Molecular weight: 553.5608

Ref: 41-ICRS0294

EMETINE HYDROCHLORIDE CRS

CAS: 316-42-7

EMETINE HYDROCHLORIDE CRS

Ref: 41-E0100000

Emetine dihydrochloride hydrate

CAS: 316-42-7

Formula: C₂₉H₄₀N₂O₄·2HCl·xH₂O

Purity: ≥ 98.0%

Color and Shape: White, off-white or pale yellow powder

Molecular weight: 553.56 (anhydrous)

Ref: 7W-GA2860

Emetine DiHCl

CAS: 316-42-7

Formula: C₂₉H₄₀N₂O₄·2HCl

Color and Shape: White To Off-White Solid

Molecular weight: 480.65 2*36.46

Ref: 4Z-E-077001

Emetine Dihydrochloride

CAS: 316-42-7

Formula: C₂₉H₄₂Cl₂N₂O₄

Purity: 95%~99%

Color and Shape: Powder

Molecular weight: 553.565

Ref: BP-BP0531-1

Emetine dihydrochloride

CAS: 316-42-7

Natural alkaloid

Formula: C₂₉H₄₀N₂O₄HCl

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 553.57

Ref: 5G-89489

Emetine dihydrochloride

CAS: 316-42-7

Alkaloid from the roots of the tropical plant Cephaelis ipecacuanha and active ingredient in ipecac. The compound is an inhibitor of protein synthesis and DNA replication. It prevents the formation of Okazaki fragments and uncouples leading and lagging strands during DNA replication. Ementine therefore selectively inhibits the lagging strand synthesis and prevents ADP-ribosylation in the S-phase of cell cycle. It can be used for the preparation and of newly synthesised DNA. The compound has been also used as antiprotozoal agent for the treatment of ameboasis.

Formula: C₂₉H₄₀N₂O₄(HCl)₂

Purity: Min. 98 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 553.56 g/mol

Ref: 3D-FE156859