CAS 316-46-1

5-Fluorouridine

Description:

5-Fluorouridine is a nucleoside analog of uridine, characterized by the presence of a fluorine atom at the 5-position of the pyrimidine ring. Its molecular formula is C₁₁H₁₃FN₂O₄, and it has a molecular weight that reflects its structure. This compound exhibits antiviral properties, particularly against certain RNA viruses, making it of interest in pharmaceutical research. 5-Fluorouridine functions by interfering with RNA synthesis, thereby inhibiting viral replication. It is soluble in water and exhibits moderate stability under physiological conditions. The compound is often utilized in biochemical studies and has potential applications in cancer therapy due to its ability to disrupt nucleic acid metabolism. Additionally, it can be incorporated into RNA, leading to the production of faulty proteins. As with many nucleoside analogs, its use may be accompanied by side effects, and its therapeutic index must be carefully evaluated in clinical settings. Overall, 5-Fluorouridine serves as a significant tool in both virology and cancer research.

Formula: C₉H₁₁FN₂O₆

InChI: InChI=1/C9H11FN2O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2H2,(H,11,16,17)/t4-,5-,6-,8-/m0/s1

InChI key: InChIKey=FHIDNBAQOFJWCA-UAKXSSHOSA-N

SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)NC(=O)C(F)=C2

Synonyms:

• 5-Fluorouracil-1beta-D-ribofuranoside
• 5-fluoro-1-beta-L-ribofuranosylpyrimidine-2,4(1H,3H)-dione
• NSC 146604
• NSC 519273
• Uridine, 5-fluoro-
• 5-Fluorouridine
• 1-(3,4-DIHYDROXY-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-2-YL)-5-FLUORO-1H-PYRIMIDINE-2,4-DIONE
• 5-FU
• 5-fur
• 2,4-DIHYDROXY-5-FLUORO-1-BETA-D-RIBOFURANOSYLPYRIMIDINE
• 5-fluorouracil 1β-d-ribofuranoside
• 5-Fluorouracil 1β-D-ribofuranoside, FUrd
• (2'R,3'R,4'S,5'R)-1-(3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-fluoro-1H-pyrimidine-2,4-dione
• FURD
• 5-FLUOROURIDINE extrapure
• 5-FLUOROURIDINE, 98+%
• 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoropyrimidine-2,4-dione
• 5-Fluorouridine97%
• FLUOROURIDINE
• 1-(beta-D-Ribofuranosyl)-5-fluorouracil
• 5-FLUOROIDINE
• 5-FLUORO-1-(BETA-D-RIBOFURANOSYL)URACIL

5-Fluorouridine, 97%

CAS: 316-46-1

5-Fluorouridine exhibits anticancer activity. It is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs. It is an active metabolite of Doxifluridine. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. So

Formula: C₉H₁₁FN₂O₆

Purity: 97%

Molecular weight: 262.19

Ref: 02-J62083

5-Fluorouridine

CAS: 316-46-1

5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine.

Formula: C₉H₁₁FN₂O₆

Purity: 99.76% - 99.85%

Color and Shape: White Powder

Molecular weight: 262.19

Ref: TM-T1349

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-1,2,3,4-tetrahydropyrimidine-2,4-dione

CAS: 316-46-1

Formula: C₉H₁₁FN₂O₆

Purity: 97%

Color and Shape: Solid

Molecular weight: 262.1918

Ref: IN-DA003MRV

5-Fluorouridine

CAS: 316-46-1

Formula: C₉H₁₁FN₂O₆

Molecular weight: 262.19

Ref: 7W-GP6172

5-Fluorouridine

CAS: 316-46-1

5-Fluorouridine

Purity: ≥98%

Molecular weight: 262.19g/mol

Ref: 54-BUP17092

5-Fluorouridine

CAS: 316-46-1

Formula: C₉H₁₁FN₂O₆

Purity: >98.0%(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 262.19

Ref: 3B-F0636

5-Fluorouridine

CAS: 316-46-1

5-Fluorouridine

Formula: C₉H₁₁FN₂O₆

Purity: 97%

Color and Shape: white solid

Molecular weight: 262.19g/mol

Ref: 54-PC4380B

5-Fluorouridine-13C,15N2

CAS: 316-46-1

Applications 5-Fluorouridine-13C,15N2 is a compound useful in organic synthesis.

Formula: C₈₁₃CH₁₁F₁₅N₂O₆

Color and Shape: Neat

Molecular weight: 265.17

Ref: TR-F596502

5-Fluoro Uridine

Controlled Product

CAS: 316-46-1

Applications 5-Fluoro Uridine is an active metabolite of Doxifluridine (D556750).
References Mori, K., et al.: Int. J. Oncol., 17, 33 (2000); Bollag, W., et al.: Eur. J. Cancer, 16, 427 (1980); Pinedo, H., et al.: J. Clin. Oncol., 6, 1653 (1988); Ishikawa, T., et al.: Biochem. Pharmacol., 55, 1091 (1998); Schuller, J., et al.: Cancer Chemother. Pharmacol., 45, 291 (2000)

Formula: C₉H₁₁FN₂O₆

Color and Shape: Neat

Molecular weight: 262.19

Ref: TR-F596500

5-Fluorouridine

CAS: 316-46-1

5-Fluorouridine, also called 1-(b-D-ribofuranosyl)-5-fluorouracil and 5-fluoro-D-uridine (FUrd), is a modified uridine nucleoside with a fluorine atom at position 5 of the uracil. 5-Fluorouridine is a highly cytotoxic metabolite of 5-fluorouracil, a drug used to treat a variety of cancers, on the market with the trade name Adrucil. Prodrugs of 5-fluorouridine have been investigated for anti-tumour properties in their own right and are close structural analogues of 5'-deoxy-5-fluorouridine, a cytostatic agent in chemotherapy.

Formula: C₉H₁₁FN₂O₆

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 262.2 g/mol

Ref: 3D-NF04076

5-Fluorouridine

CAS: 316-46-1

Formula: C₉H₁₁FN₂O₆

Purity: 97%

Color and Shape: Solid

Molecular weight: 262.193

Ref: 10-F006461

5-Fluorouridine (5-FUrd) extrapure, 98%

CAS: 316-46-1

Formula: C₉H₁₁FN₂O₆

Purity: min. 99%

Color and Shape: White to off white, Powder

Molecular weight: 262.20

Ref: SR-28329