CAS 31690-11-6

5,10-Methylene-(6R)-tetrahydrofolic acid

Description:

5,10-Methylene-(6R)-tetrahydrofolic acid, also known as 5,10-methylenetetrahydrofolate, is a biologically active form of folate, a B-vitamin essential for various metabolic processes. This compound plays a crucial role in one-carbon metabolism, which is vital for DNA synthesis, repair, and methylation, as well as amino acid metabolism. It is characterized by its ability to donate a methylene group in biochemical reactions, particularly in the conversion of homocysteine to methionine. The (6R) designation indicates the specific stereochemistry of the molecule, which is important for its biological activity. As a water-soluble vitamin, it is involved in the synthesis of nucleotides and is essential for cell division and growth. Deficiencies in folate or its derivatives can lead to various health issues, including anemia and increased risk of neural tube defects during pregnancy. The CAS number 31690-11-6 uniquely identifies this compound in chemical databases, facilitating research and regulatory processes.

Formula: C₂₀H₂₃N₇O₆

InChI: InChI=1S/C20H23N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,12-13H,5-9H2,(H,23,30)(H,28,29)(H,32,33)(H4,21,22,24,25,31)/t12-,13+/m1/s1

InChI key: InChIKey=QYNUQALWYRSVHF-OLZOCXBDSA-N

SMILES: O=C1C=2N3[C@@](CN(C3)C4=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C4)(CNC2NC(N)=N1)[H]

Synonyms:

• (6R)-5,10-Methylene-5,6,7,8-tetrahydrofolic acid
• (6R)-5,10-Methylenetetrahydrofolate
• 31690-11-6
• 5,10-Methylene-(6R)-tetrahydrofolic acid
• <span class="text-smallcaps">L</span>-(+)-Methylenetetrahydrofolic acid
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-(3-amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-, (R)-
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[(6aR)-3-amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo[1,5-f]pteridin-8(9H)-yl]benzoyl]-
• Arfolitixorin
• Glutamic acid, N-[p-(3-amino-5,6,6a,7-tetrahydro-1-hydroxyimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-, <span class="text-smallcaps">L</span>-(+)-
• N-[4-[(6aR)-3-Amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo[1,5-f]pteridin-8(9H)-yl]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• d-N⁵,N¹⁰-Methylene-<span class="text-smallcaps">L</span>-tetrahydrofolic acid
• L-Glutamic acid, N-[4-(3-amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-, (R)-
• L-Glutamic acid, N-[4-[(6aR)-3-amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo[1,5-f]pteridin-8(9H)-yl]benzoyl]-
• N-[4-[(6aR)-3-Amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo[1,5-f]pteridin-8(9H)-yl]benzoyl]-L-glutamic acid
• d-N5,N10-Methylene-L-tetrahydrofolic acid

Arfolitixorin

CAS: 31690-11-6

Formula: C₂₀H₂₃N₇O₆

Color and Shape: Neat

Molecular weight: 457.44

Ref: TR-A767530

Arfolitixorin Hemisulfate Salt

Controlled Product

CAS: 31690-11-6

Formula: C₂₀H₂₃N₇O₆·x(H₂SO₄)

Color and Shape: Neat

Molecular weight: 555.5

Ref: TR-A427120

Levofolinate EP Impurity I

CAS: 31690-11-6

Formula: C₂₀H₂₃N₇O₆

Molecular weight: 457.45

Ref: ST-EA-CP-L57009

Arfolitixorin

CAS: 31690-11-6

Arfolitixorin is an antifolate modulator.

Formula: C₂₀H₂₃N₇O₆

Color and Shape: Solid

Molecular weight: 457.44

Ref: TM-T26654

5,10-Methylenetetrahydrofolate

CAS: 31690-11-6

5,10-Methylenetetrahydrofolate is a dinucleotide phosphate that is the precursor to tetrahydrofolate (THF), which is required for the synthesis of DNA. 5,10-Methylenetetrahydrofolate is synthesized from dihydrofolate (DHF) and formaldehyde through two reactions catalyzed by enzymes formyltetrahydrofolate synthase and dihydrofolate reductase. The enzyme formyltetrahydrofolate synthase uses 5,10-methylenetetrahydropteroyltriglutamate as a substrate and produces 5,10-methylenetetrahydrofolic acid. This enzyme can be inhibited by sulfonamides or trimethoprim. The enzyme dihydrofolate reductase uses Dihydrofolates, such as DHF or THF as substrates and produces

Formula: C₂₀H₂₃N₇O₆

Purity: Min. 95%

Molecular weight: 457.44 g/mol

Ref: 3D-FM171168

Calcium Levofolinate EP Impurity I Disodium Salt

CAS: 154705-24-5, 31690-11-6

Formula: C₂₀H₂₁N₇O₆·2Na

Molecular weight: 455.43 2*22.99

Ref: 4Z-C-451002