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CAS 31716-01-5

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Tosyl pleuromutilin

Description:
Tosyl pleuromutilin is a synthetic antibiotic derived from the natural product pleuromutilin, which is produced by the fungus *Pleurotus mutilus*. This compound is characterized by its ability to inhibit bacterial protein synthesis, making it effective against a range of Gram-positive bacteria, including some strains resistant to other antibiotics. Tosyl pleuromutilin features a tosyl group, which enhances its pharmacological properties, such as solubility and stability. The compound is typically administered topically or via other non-systemic routes to minimize potential side effects associated with systemic antibiotic use. Its mechanism of action involves binding to the bacterial ribosome, specifically targeting the peptidyl transferase center, which disrupts the translation process. Due to its unique structure and mechanism, tosyl pleuromutilin is of interest in the development of new antimicrobial therapies, particularly in the face of rising antibiotic resistance. Safety and efficacy profiles are continually evaluated in clinical settings to ensure its appropriate use in treating bacterial infections.
Synonyms:
  • TiaMulin Related CoMpound A
  • (3aR,4R,5R,7S,8S,9R,9aS,12R)-8-Hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-(tosyloxy)acetate
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