CAS 31750-48-8

Desmethyltamoxifen

Description:

Desmethyltamoxifen is a chemical compound that serves as a metabolite of tamoxifen, a well-known selective estrogen receptor modulator (SERM) used primarily in the treatment of estrogen receptor-positive breast cancer. It is characterized by its ability to bind to estrogen receptors, albeit with different affinities compared to tamoxifen itself. Desmethyltamoxifen exhibits both estrogenic and anti-estrogenic properties, which can influence its biological activity in various tissues. The compound is lipophilic, allowing it to easily cross cell membranes, and it is primarily metabolized in the liver. Its pharmacokinetics can vary among individuals, affecting its therapeutic efficacy and side effects. Additionally, desmethyltamoxifen has been studied for its potential role in the development of drug resistance in breast cancer treatment. Understanding its characteristics is crucial for optimizing tamoxifen therapy and managing its associated risks. Overall, desmethyltamoxifen plays a significant role in the pharmacological landscape of breast cancer treatment and research.

Formula: C₂₅H₂₇NO

InChI: InChI=1S/C25H27NO/c1-3-24(20-10-6-4-7-11-20)25(21-12-8-5-9-13-21)22-14-16-23(17-15-22)27-19-18-26-2/h4-17,26H,3,18-19H2,1-2H3/b25-24-

InChI key: InChIKey=NYDCDZSEEAUOHN-IZHYLOQSSA-N

SMILES: C(=C(/CC)\C1=CC=CC=C1)(\C2=CC=C(OCCNC)C=C2)/C3=CC=CC=C3

Synonyms:

• 2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N-methylethanamine
• Demethyltamoxifen
• Desmethyltamoxifen
• Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1-butenyl]phenoxy]-N-methyl-
• Ethanamine,2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N-methyl-, (Z)-
• Ethanamine,2-[4-[(1Z)-1,2-diphenyl-1-butenyl]phenoxy]-N-methyl- (9CI)
• Ethylamine, 2-[p-(1,2-diphenyl-1-butenyl)phenoxy]-N-methyl-, (Z)-
• Ethylamine,2-[p-(1,2-diphenyl-1-butenyl)phenoxy]-N-methyl-, (Z)- (8CI)
• Ici 55548
• N-Demethyltamoxifen
• N-Desmethyltamoxifen
• Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N-methyl-
• (Z)-2-[4-(1,2-DIPHENYL-1-BUTENYL)PHENOXY]-N-METHYL-ETHANAMINE
• 2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(4-((z)-ethanamin
• 2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(p-((z)-ethylamin
• cis-2-(p-(1,2-diphenyl-1-butenyl)phenoxy)-n-methylethylamine
• N-DEMETHYLTAMOXIFEN, HYDROCHLORIDE
• N-DESMETHYL TAMOXIFEN HCL
• ici55,548
• Tamoxifen EP Impurity F
• (Z)-2-(4-(1,2-diphenylbut-1-en-1-yl)phenoxy)-N-methylethanamine
• 2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N-methylethanamine HCl

N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE

CAS: 31750-48-8

Formula: C₂₅H₂₇NO

Purity: 97%

Color and Shape: Solid

Molecular weight: 357.4880

Ref: IN-DA00BZM5

(Z)-2-(4-(1,2-Diphenylbut-1-en-1-yl)phenoxy)-N-methylethanamine

CAS: 31750-48-8

(Z)-2-(4-(1,2-Diphenylbut-1-en-1-yl)phenoxy)-N-methylethanamine

Purity: 97%

Molecular weight: 357.5g/mol

Ref: 54-OR1054407

N-Desmethyltamoxifen

CAS: 31750-48-8

N-Desmethyltamoxifen, tamoxifen's main human metabolite, regulates AML cell ceramide metabolism and is a more potent PKC inhibitor than tamoxifen.

Formula: C₂₅H₂₇NO

Purity: 98%

Color and Shape: Solid

Molecular weight: 357.49

Ref: TM-T12148L

Tamoxifen EP Impurity F

CAS: 31750-48-8

Formula: C₂₅H₂₇NO

Molecular weight: 357.50

Ref: ST-EA-CP-T40006

N-Desmethyltamoxifen

CAS: 31750-48-8

N-Desmethyltamoxifen is a synthetic peptide that is an inhibitor of the estrogen receptor. It binds to the estrogen receptor and prevents it from binding to other proteins, thereby inhibiting the effects of estrogen. N-Desmethyltamoxifen inhibits protein interactions with the estrogen receptor by preventing ligand binding. N-Desmethyltamoxifen can also be used as a research tool for investigating protein interactions, ligands, and receptors. This drug has high purity and is suitable for use in life science research such as ion channel studies or antibody production.

Formula: C₂₅H₂₇NO

Purity: Min. 95%

Molecular weight: 357.5 g/mol

Ref: 3D-GBA75048