CAS 318250-11-2

P1-(2'-Deoxycytidin-5'-yl)-P4-(uridin-5'-yl)tetraphosphate tetrasodium salt

Description:

P1-(2'-Deoxycytidin-5'-yl)-P4-(uridin-5'-yl)tetraphosphate tetrasodium salt, commonly referred to as a nucleotide analog, is a synthetic compound that plays a significant role in biochemical research, particularly in studies involving nucleic acid metabolism and signaling pathways. This compound consists of two nucleoside components, 2'-deoxycytidine and uridine, linked by phosphate groups, which contribute to its function as a nucleotide. The tetrasodium salt form enhances its solubility in aqueous solutions, making it suitable for various laboratory applications. Characteristically, it exhibits properties typical of nucleotides, such as the ability to participate in enzymatic reactions and serve as a substrate for kinases. Its structural features allow it to mimic natural nucleotides, which can be useful in studying enzyme kinetics and interactions with nucleic acids. Additionally, the compound's stability and reactivity can be influenced by factors such as pH and ionic strength, which are important considerations in experimental design. Overall, this compound is valuable for its potential applications in molecular biology and biochemistry.

Formula: C₁₈H₂₃N₅Na₄O₂₁P₄

InChI: InChI=1/C18H27N5O21P4.4Na/c19-11-1-3-22(17(28)20-11)13-5-8(24)9(40-13)6-38-45(30,31)42-47(34,35)44-48(36,37)43-46(32,33)39-7-10-14(26)15(27)16(41-10)23-4-2-12(25)21-18(23)29;;;;/h1-4,8-10,13-16,24,26-27H,5-7H2,(H,30,31)(H,32,33)(H,34,35)(H,36,37)(H2,19,20,28)(H,21,25,29);;;;/q;4*+1/p-4/t8-,9+,10+,13+,14+,15+,16+;;;;/m0..../s1

SMILES: c1cn(C2CC(C(COP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OCC3C(C(C(n4ccc(nc4=O)O)O3)O)O)O2)O)c(nc1=N)O.[Na].[Na].[Na].[Na]

Synonyms:

• Denufosol tetrasodium
• dCp4U
• Ins-37217
• Uridine 5'-(pentahydrogen tetraphosphate) P'''--5'-ester with 2'-deoxycytidine tetrasodium salt
• tetrasodium [[[[(3S,5R)-5-(4-amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl] [(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl hydrogen phosphate
• tetrasodium [[[[(2R,3S,5R)-5-(4-amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]oxy-oxido-phosphoryl]oxy-oxido-phosphoryl] [(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl phosphate

Denufosol tetrasodium

CAS: 318250-11-2

Denufosol is a P2Y2 agonist potentially for the treatment of cystic fibrosis.

Formula: C₁₈H₂₃N₅Na₄O₂₁P₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 861.25

Ref: TM-T27146

Denufosol tetrasodium

CAS: 318250-11-2

A P2Y2 receptor agonist that has been studied in cystic fibrosis and retinal diseases such as retinal detachment. Denufosol was studied as an inhaled drug for cystic fibrosis, due to its ability to activate an alternative chloride channel and avoiding the defective CFTR chloride channel. This enhances hydration of the lung mucosa and improves mucociliary clearance.  The drug did not progress from phase III clinical trials. Denufosol resulted in subretinal fluid reabsorption in in vivo model of retinal detachment.

Formula: C₁₈H₂₃N₅Na₄O₂₁P₄

Purity: Min. 90 Area-%

Color and Shape: Powder

Molecular weight: 861.25 g/mol

Ref: 3D-ND45968