CAS 31883-05-3

Moricizine

Description:

Moricizine is an antiarrhythmic medication primarily used to treat certain types of irregular heartbeats, particularly ventricular arrhythmias. It belongs to the class of drugs known as Class I antiarrhythmics, which work by blocking sodium channels in cardiac cells, thereby stabilizing the cardiac membrane and reducing excitability. Moricizine is characterized by its ability to prolong the refractory period and decrease conduction velocity in the heart. It is typically administered orally and is metabolized in the liver, with its pharmacokinetics influenced by factors such as liver function and concomitant medications. Common side effects may include dizziness, fatigue, and gastrointestinal disturbances. Due to its potential for proarrhythmic effects, careful monitoring of cardiac function is essential during treatment. Moricizine's use has declined with the advent of newer antiarrhythmic agents that offer improved safety profiles and efficacy. As with any medication, it is crucial to use Moricizine under the guidance of a healthcare professional, considering individual patient factors and potential drug interactions.

Formula: C₂₂H₂₅N₃O₄S

InChI: InChI=1S/C22H25N3O4S/c1-2-29-22(27)23-16-7-8-20-18(15-16)25(17-5-3-4-6-19(17)30-20)21(26)9-10-24-11-13-28-14-12-24/h3-8,15H,2,9-14H2,1H3,(H,23,27)

InChI key: InChIKey=FUBVWMNBEHXPSU-UHFFFAOYSA-N

SMILES: C(CCN1CCOCC1)(=O)N2C=3C(SC=4C2=CC=CC4)=CC=C(NC(OCC)=O)C3

Synonyms:

• Carbamic acid, N-[10-[3-(4-morpholinyl)-1-oxopropyl]-10H-phenothiazin-2-yl]-, ethyl ester
• Ethyl 10-(β-N-morpholinylpropionyl)phenothiazine-2-carbamate
• Ethyl 10-(β-morpholinopropionyl)phenothiazine-2-carbamate
• G 214
• Moracizin
• Moracizina
• Moracizine
• Moricizine
• Phenothiazine-2-carbamic acid, 10-(3-morpholinopropionyl)-, ethyl ester
• [10-(3-Morpholin-4-yl-propionyl)-10H-phenothiazin-2-yl]-carbamic acid ethyl ester
• Carbamic acid, [10-[3-(4-morpholinyl)-1-oxopropyl]-10H-phenothiazin-2-yl]-, ethyl ester

Moracizine

CAS: 31883-05-3

Formula: C₂₂H₂₅N₃O₄S

Molecular weight: 427.52

Ref: 7W-GP4633

Moracizine

CAS: 31883-05-3

Formula: C₂₂H₂₅N₃O₄S

Molecular weight: 427.52

Ref: 4Z-M-241001

Moracizine-d8

CAS: 31883-05-3

Formula: C₂₂H₁₇D₈N₃O₄S

Molecular weight: 435.57

Ref: 4Z-M-241002

Moricizine

Controlled Product

CAS: 31883-05-3

Applications Moricizine, is Phenothiazine (P318040) derivative, which It was used as an Antiarrhythmic agent. It is also shown that moracizine is effective in suppressing premature ventricular contractions, couplets, and nonsustained ventricular tachycardia.
References Ahmmed, G. U., et al.: Vas. Pharm., 38, 131 (2002), Bansode, T., et al.: Eur. J. Med. Chem., 44, 5094 (2009), Baell, J., et al.: J. Med. Chem., 53, 2719 (2010), Howard, P., et al.: Environ. Sci. Technol., 44, 2277 (2010), Koren, J., et al.: J. Biol. Chem., 285, 2498 (2010), Amobi, N., et al.: Eur. J. Pharmacol., 627, 285 (2010),

Formula: C₂₂H₂₅N₃O₄S

Color and Shape: Neat

Molecular weight: 427.52

Ref: TR-M635025

Moricizine

CAS: 31883-05-3

Moricizine is an antiarrhythmia agent which is used primarily for ventricular rhythm disturbances.

Formula: C₂₂H₂₅N₃O₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 427.52

Ref: TM-T16127