CAS 31884-77-2

Meclizine dihydrochloride monohydrate

Description:

Meclizine dihydrochloride monohydrate is an antihistamine commonly used to prevent and treat nausea, vomiting, and dizziness caused by motion sickness and vertigo. It is a white to off-white crystalline powder that is soluble in water and has a molecular formula that reflects its dihydrochloride and monohydrate forms. The substance acts primarily as an antagonist of the H1 histamine receptor, which helps to alleviate symptoms associated with vestibular disorders. In addition to its antihistaminic properties, meclizine exhibits anticholinergic effects, contributing to its efficacy in managing motion sickness. The compound is typically administered orally and is available in various formulations, including tablets and chewable forms. Side effects may include drowsiness, dry mouth, and blurred vision, which are common with many antihistamines. Due to its sedative properties, caution is advised when operating machinery or driving after taking meclizine. Overall, meclizine dihydrochloride monohydrate is a well-established medication in the management of motion-related ailments.

Formula: C₂₅H₂₇ClN₂·2ClH·H₂O

InChI: InChI=1S/C25H27ClN2.2ClH.H2O/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23;;;/h2-13,18,25H,14-17,19H2,1H3;2*1H;1H2

InChI key: InChIKey=KDLHYOMCWBWLMM-UHFFFAOYSA-N

SMILES: C(N1CCN(CC2=CC(C)=CC=C2)CC1)(C3=CC=C(Cl)C=C3)C4=CC=CC=C4.Cl.O

Synonyms:

• 1-(p-Chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)piperazine dihydrochloride monohydrate
• Meclizine HCl hydrate
• Meclizine dihydrochloride monohydrate
• Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)-, dihydrochloride, monohydrate
• Piperazine, 1-(p-chloro-α-phenylbenzyl)-4-(m-methylbenzyl)-, dihydrochloride, monohydrate
• Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, hydrochloride, hydrate (1:2:1)

Meclizine Hydrochloride

CAS: 31884-77-2

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Formula: C₂₅H₂₇ClN₂·2ClH·H₂O

Color and Shape: White Yellow Powder

Molecular weight: 480.1502

Ref: 45-1377009

MECLIZINE HYDROCHLORIDE (500 MG)

CAS: 31884-77-2

Formula: C₂₅H₃₁Cl₃N₂O

Color and Shape: Solid

Molecular weight: 481.8854

Ref: IN-DA00BY2Z

Meclizine Dihydrochloride Monohydrate

CAS: 31884-77-2

Applications Meclizine Dihydrochloride Monohydrate is an antiemetic.
References Cohen, B., et al.: Arch. Neurol., 27, 129 (1972),

Formula: C₂₅H₂₇ClN₂·2ClH·H₂O

Color and Shape: Neat

Molecular weight: 481.89

Ref: TR-M202700

Meclizine dihydrochloride monohydrate

CAS: 31884-77-2

Meclizine is a drug that is used to treat symptoms of gastrointestinal disorders such as inflammatory bowel disease, bowel disease and nausea. It is a histamine antagonist with anticholinergic effects that stabilizes the surface of tablets and suppositories. Meclizine also has an inhibitory effect on human liver energy metabolism and cholinergic activity in the central nervous system. Meclizine can be found in pharmaceutical preparations, including prescription drugs and over-the-counter medications. The drug binds to constitutive androstane receptor (CAR) nuclear hormone receptors, which are involved in regulating gene transcription. In transgenic animals, meclizine has been shown to cause light emission from skin cells.

Formula: C₂₅H₃₁Cl₃N₂O

Purity: (Titration) Min. 97%

Color and Shape: Powder

Molecular weight: 481.88 g/mol

Ref: 3D-FM25025

Meclizine N1-(3-Methylbenzyl)piperazinium Bromide

Controlled Product

CAS: 31884-77-2

Formula: C₃₃H₃₆ClN₂•Br

Color and Shape: Neat

Molecular weight: 576.01

Ref: TR-M658250