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CAS 31969-05-8

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Bunolol hydrochloride

Description:
Bunolol hydrochloride is a synthetic beta-adrenergic antagonist primarily used in the treatment of glaucoma and ocular hypertension. It functions by reducing intraocular pressure through decreased aqueous humor production. This compound is characterized by its ability to selectively block beta-1 and beta-2 adrenergic receptors, which contributes to its therapeutic effects. Bunolol hydrochloride is typically administered as an eye drop solution, and its pharmacological profile includes properties such as a relatively long duration of action and good ocular penetration. The hydrochloride salt form enhances its solubility and stability in aqueous solutions. In terms of safety, like other beta-blockers, it may have systemic effects, particularly in patients with pre-existing respiratory or cardiovascular conditions. Common side effects can include ocular irritation, dry eyes, and potential systemic absorption leading to bradycardia or hypotension. Overall, Bunolol hydrochloride is an important medication in ophthalmology, providing effective management of elevated intraocular pressure.
Formula:C17H25NO3·ClH
InChI:InChI=1S/C17H25NO3.ClH/c1-17(2,3)18-10-12(19)11-21-16-9-5-6-13-14(16)7-4-8-15(13)20;/h5-6,9,12,18-19H,4,7-8,10-11H2,1-3H3;1H
InChI key:InChIKey=DNTDOBSIBZKFCP-UHFFFAOYSA-N
SMILES:O(CC(CNC(C)(C)C)O)C1=C2C(=CC=C1)C(=O)CCC2.Cl
Synonyms:
  • (?à)-Bunolol hydrochloride
  • 1(2H)-Naphthalenone, 5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-, hydrochloride, (±)-
  • 1(2H)-Naphthalenone, 5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-, hydrochloride
  • 1(2H)-Naphthalenone,5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-, hydrochloride, (?à)- (8CI)
  • 1(2H)-Naphthalenone,5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-, hydrochloride(9CI)
  • 1(2H)-Naphthalenone,5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-, hydrochloride,(?à)-
  • Bunolol hydrochloride
  • W 6412A
  • W6412A
  • dl-Bunolol hydrochloride
  • 1(2H)-Naphthalenone, 5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-, hydrochloride (1:1)
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