CAS 320-67-2
:Azacytidine
Description:
Azacytidine, with the CAS number 320-67-2, is a nucleoside analog of cytidine, characterized by the presence of a nitrogen atom in the pyrimidine ring. This modification alters its biological activity, making it a potent inhibitor of DNA methylation. Azacytidine is primarily used in the treatment of certain types of cancer, particularly myelodysplastic syndromes and acute myeloid leukemia, as it can induce differentiation and apoptosis in malignant cells. The compound is typically administered via injection and has a relatively short half-life in the body. Its mechanism of action involves incorporation into RNA and DNA, leading to hypomethylation of genes that are silenced in cancer. Azacytidine is also known for its ability to reactivate tumor suppressor genes, contributing to its therapeutic effects. However, it can cause side effects, including myelosuppression, gastrointestinal disturbances, and potential long-term risks. Overall, azacytidine represents a significant advancement in epigenetic therapy, highlighting the importance of DNA methylation in cancer treatment.
Formula:C8H12N4O5
InChI:InChI=1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1
InChI key:InChIKey=NMUSYJAQQFHJEW-KVTDHHQDSA-N
SMILES:O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)N=C(N)N=C2
Synonyms:- 1,3,5-Triazin-2(1H)-one, 4-amino-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
- 1,3,5-Triazin-2(1H)-one, 4-amino-1-β-D-ribofuranosyl-
- 2-(β-D-Ribofuranosyl)-4-amino-1,3,5-triazin-2-on
- 2-(β-D-ribofurannosyl)-4-amino-1,3,5-triazine-2-one
- 2-(β-D-ribofuranosil)-4-amino-1,3,5-triazin-2-ona
- 2-(β-D-ribofuranosyl)-4-amino-1,3,5-triazin-2-one
- 4-Amino-1-Beta-D-Ribofuranosyl-S-Triazin-2(1H)-On
- 4-Amino-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-1,3,5-triazin-2(1H)-one
- 4-amino-1-D-lyxofuranosyl-1,3,5-triazin-2(1H)-one
- 4-amino-1-beta-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
- 4-amino-1-beta-D-ribofuranosyl-s-triazin-2(1H)-one
- 4-amino-1-pentofuranosyl-1,3,5-triazin-2(1H)-one
- 5 Azc
- 5-Ac
- 5-Azac
- 5-Azacitidine
- 5-Azcr
- 5-Triazin-2(1H)-One,4-Amino-1-Beta-D-Ribofuranosyl-3
- Antibiotic u 18496
- Antibioticu18496
- Azacitidine
- Azacytidine
- Cc 486
- Ladakamycin
- Ledakamycin
- Mylosar
- Nci-C01569
- Nsc 103-627
- Nsc-102816
- U 18496
- U18496
- Vidaza
- Wr 183027
- s-Triazin-2(1H)-one, 4-amino-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
- s-Triazin-2(1H)-one, 4-amino-1-β-D-ribofuranosyl-
- 4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
- See more synonyms
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Found 16 products.
5-Azacytidine
CAS:Formula:C8H12N4O5Purity:>98.0%(T)Color and Shape:White to Almost white powder to crystalMolecular weight:244.215-Azacytidine, 98%
CAS:<p>Causes DNA demethylation or hemi-demethylation; a powerful mutagen</p>Formula:C8H12N4O5Purity:98%Color and Shape:White to off-white, Powder or crystals or crystalline powderMolecular weight:244.21Azacitidine
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormula:C8H12N4O5Color and Shape:White Off-White PowderMolecular weight:244.080774-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one
CAS:Formula:C8H12N4O5Purity:98%Color and Shape:SolidMolecular weight:244.20475-Azacytidine
CAS:<p>5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity.</p>Formula:C8H12N4O5Purity:99.31% - 99.79%Color and Shape:Crystals From Methanol Physical Description White Crystalline Powder (Ntp 1992)Molecular weight:244.25-Azacytidine
CAS:Formula:C8H12N4O5Purity:≥ 98.0% (dried basis)Color and Shape:White to off-white crystalline powderMolecular weight:244.205-Azacytidine
CAS:<p>Applications A potent growth inhibitor and cytotoxic agent. It acts as a demethylating agent by inhibiting DNA methyltransferase.<br>References Kusaba, H., et al.: Eur. J. Biochem., 262, 924 (1999), Broday, L., et al.: Mol. Cell Biol., 19, 3198 (1999), Qian, X., et al.: Am. J. Pathol., 153, 1475 (1999), Canova, C., et al.: Mech. Ageing Dev., 101, 153 (1998)<br></p>Formula:C8H12N4O5Color and Shape:Off-WhiteMolecular weight:244.205-Azacytidine-15N4
CAS:Controlled Product<p>Applications Labelled Azacytidine (A796000), a potent growth inhibitor and cytotoxic agent. It acts as a demethylating agent by inhibiting DNA methyltransferase.<br>References Kusaba, H., et al.: Eur. J. Biochem., 262, 924 (1999), Broday, L., et al.: Mol. Cell Biol., 19, 3198 (1999), Qian, X., et al.: Am. J. Pathol., 153, 1475 (1999), Canova, C., et al.: Mech. Ageing Dev., 101, 153 (1998)<br></p>Formula:C8H1215N4O5Color and Shape:White To Off-WhiteMolecular weight:248.185-Azacytidine
CAS:<p>An azanucleoside and epigenetic modulator that interferes with nucleic acid metabolism. The compound gets incorporated into RNA and inhibits ribonucleotide reductase subunit RRM2 in leukemia cell lines. Intracellularly, 5-azacytidine can get converted into 2′-deoxy-5-azacytidine (decitabine) and subsequently incorporated in DNA, where it irreversibly inhibits DNMT1 methyltransferase. In human epithelial cell lines, this compound decreases Src-activated expression of a histone chaperone CAF1 and inhibits cell motility and invasiveness.</p>Formula:C8H12N4O5Purity:Min. 95%Color and Shape:White Off-White PowderMolecular weight:244.21 g/mol5-Azacytidine extrapure, 98%
CAS:Formula:C8H12N4O5Purity:min. 98%Color and Shape:White to off-white, Crystalline powderMolecular weight:244.21
![4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-o…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA003824.jpg&w=3840&q=75)
