CAS 320-67-2: Azacytidine

Description: Azacytidine, with the CAS number 320-67-2, is a nucleoside analog of cytidine, characterized by the presence of a nitrogen atom in the pyrimidine ring. This modification alters its biological activity, making it a potent inhibitor of DNA methylation. Azacytidine is primarily used in the treatment of certain types of cancer, particularly myelodysplastic syndromes and acute myeloid leukemia, as it can induce differentiation and apoptosis in malignant cells. The compound is typically administered via injection and has a relatively short half-life in the body. Its mechanism of action involves incorporation into RNA and DNA, leading to hypomethylation of genes that are silenced in cancer. Azacytidine is also known for its ability to reactivate tumor suppressor genes, contributing to its therapeutic effects. However, it can cause side effects, including myelosuppression, gastrointestinal disturbances, and potential long-term risks. Overall, azacytidine represents a significant advancement in epigenetic therapy, highlighting the importance of DNA methylation in cancer treatment.

Formula: C₈H₁₂N₄O₅

InChI: InChI=1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1

InChI key: InChIKey=NMUSYJAQQFHJEW-KVTDHHQDSA-N

SMILES: O=C1N=C(N=CN1C2OC(CO)C(O)C2O)N

Synonyms:

• 1,3,5-Triazin-2(1H)-one, 4-amino-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• 1,3,5-Triazin-2(1H)-one, 4-amino-1-β-D-ribofuranosyl-
• 2-(β-D-Ribofuranosyl)-4-amino-1,3,5-triazin-2-on
• 2-(β-D-ribofurannosyl)-4-amino-1,3,5-triazine-2-one
• 2-(β-D-ribofuranosil)-4-amino-1,3,5-triazin-2-ona
• 2-(β-D-ribofuranosyl)-4-amino-1,3,5-triazin-2-one
• 4-Amino-1-Beta-D-Ribofuranosyl-S-Triazin-2(1H)-On
• 4-Amino-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-1,3,5-triazin-2(1H)-one
• 4-amino-1-D-lyxofuranosyl-1,3,5-triazin-2(1H)-one
• 4-amino-1-beta-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
• 4-amino-1-beta-D-ribofuranosyl-s-triazin-2(1H)-one
• 4-amino-1-pentofuranosyl-1,3,5-triazin-2(1H)-one
• 5 Azc
• 5-Ac
• 5-Azac
• 5-Azacitidine
• 5-Azcr
• 5-Triazin-2(1H)-One,4-Amino-1-Beta-D-Ribofuranosyl-3
• Antibiotic u 18496
• Antibioticu18496
• Azacitidine
• Azacytidine
• Cc 486
• Ladakamycin
• Ledakamycin
• Mylosar
• Nci-C01569
• Nsc 103-627
• Nsc-102816
• U 18496
• U18496
• Vidaza
• Wr 183027
• s-Triazin-2(1H)-one, 4-amino-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• s-Triazin-2(1H)-one, 4-amino-1-β-D-ribofuranosyl-
• 4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
• 5-Azacytidine

5-Azacytidine

CAS: 320-67-2

• Formula: C₈H₁₂N₄O₅
• Purity: >98.0%(T)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 244.21

5-Azacytidine, 98%

CAS: 320-67-2

5-Azacytidine, its incorporation into RNA alters RNA synthesis and processing, and results in inhibition of …

• Formula: C₈H₁₂N₄O₅
• Purity: 98%
• Color and Shape: White to off-white, Powder or crystals or crystalline powder
• Molecular weight: 244.21

Azacitidine

CAS: 320-67-2

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

• Formula: C₈H₁₂N₄O₅
• Color and Shape: White Off-White Powder
• Molecular weight: 244.08077

5-Azacytidine

CAS: 320-67-2

• Formula: C₈H₁₂N₄O₅
• Purity: 95%
• Color and Shape: Solid
• Molecular weight: 244.20467999999997

5-Azacytidine

CAS: 320-67-2

5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity.

• Formula: C₈H₁₂N₄O₅
• Purity: 99.31% - 99.79%
• Color and Shape: Crystals From Methanol Physical Description White Crystalline Powder (Ntp 1992)
• Molecular weight: 244.2

5-Azacytidine

CAS: 320-67-2

• Formula: C₈H₁₂N₄O₅
• Purity: ≥ 98.0% (dried basis)
• Color and Shape: White to off-white crystalline powder
• Molecular weight: 244.20

Azacitidine

CAS: 320-67-2

• Formula: C₈H₁₂N₄O₅
• Color and Shape: White To Off-White Solid
• Molecular weight: 244.21

5-Azacytidine

CAS: 320-67-2

• Purity: 99.61%
• Molecular weight: 244.2g/mol

Azacitidine Impurity 3

CAS: 320-67-2

• Formula: C₁₄H₁₈N₄O₈
• Color and Shape: Off-White Solid
• Molecular weight: 370.32

5-Azacytidine

CAS: 320-67-2

• Purity: 98%
• Molecular weight: 244.20g/mol

5-Azacytidine, 99%

CAS: 320-67-2

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Formula: C₈H₁₂N₄O₅
• Purity: 99%
• Color and Shape: Crystalline powder, White to off-white
• Molecular weight: 244.21

Azacitidine

CAS: 320-67-2

• Formula: C₈H₁₂N₄O₅
• Color and Shape: Neat
• Molecular weight: 244.20

5-Azacytidine

CAS: 320-67-2

• Purity: 97.0%
• Color and Shape: Solid
• Molecular weight: 244.20700073242188

5-Azacytidine

CAS: 320-67-2

Applications A potent growth inhibitor and cytotoxic agent. It acts as a demethylating agent by …

• Formula: C₈H₁₂N₄O₅
• Color and Shape: Off-White
• Molecular weight: 244.20

5-Azacytidine-15N4

CAS: 320-67-2

Applications Labelled Azacytidine (A796000), a potent growth inhibitor and cytotoxic agent. It acts as a …

• Formula: C₈H₁₂₁₅N₄O₅
• Color and Shape: White To Off-White
• Molecular weight: 248.18

5-Azacytidine

CAS: 320-67-2

An azanucleoside and epigenetic modulator that interferes with nucleic acid metabolism. The compound gets incorporated …

• Formula: C₈H₁₂N₄O₅
• Purity: Min. 95%
• Color and Shape: White Off-White Powder
• Molecular weight: 244.21 g/mol

5-Azacytidine extrapure, 98%

CAS: 320-67-2

• Formula: C₈H₁₂N₄O₅
• Purity: min. 98%
• Color and Shape: White, Crystalline powder
• Molecular weight: 244.21