CAS 320345-99-1

Aclidinium bromide

Description:

Aclidinium bromide is a long-acting muscarinic antagonist (LAMA) primarily used in the management of chronic obstructive pulmonary disease (COPD). It functions by inhibiting the action of acetylcholine on muscarinic receptors in the airways, leading to bronchodilation and improved airflow. The substance is characterized by its chemical formula, which includes a quaternary ammonium structure, contributing to its pharmacological properties. Aclidinium bromide is typically administered via inhalation, allowing for localized action in the lungs while minimizing systemic side effects. It has a relatively long duration of action, which supports once or twice-daily dosing regimens. The compound is known for its favorable safety profile, with common side effects including throat irritation and cough. Additionally, aclidinium bromide is often formulated in combination with other medications to enhance therapeutic efficacy in managing respiratory conditions. Its development reflects ongoing efforts to improve treatment options for patients with obstructive airway diseases.

Formula: C₂₆H₃₀NO₄S₂·Br

InChI: InChI=1S/C26H30NO4S2.BrH/c28-25(26(29,23-9-4-17-32-23)24-10-5-18-33-24)31-22-19-27(14-11-20(22)12-15-27)13-6-16-30-21-7-2-1-3-8-21;/h1-5,7-10,17-18,20,22,29H,6,11-16,19H2;1H/q+1;/p-1/t20?,22-,27?;/m0./s1

InChI key: InChIKey=XLAKJQPTOJHYDR-QTQXQZBYSA-M

SMILES: C(CCOC1=CC=CC=C1)[N+]23C[C@H](OC(C(O)(C4=CC=CS4)C5=CC=CS5)=O)C(CC2)CC3.[Br-]

Synonyms:

• (3R)-(2-Hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide
• 1-Azoniabicyclo[2.2.2]octane, 3-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-1-(3-phenoxypropyl)-, bromide (1:1), (3R)-
• 1-Azoniabicyclo[2.2.2]octane, 3-[(hydroxydi-2-thienylacetyl)oxy]-1-(3-phenoxypropyl)-, bromide, (3R)-
• Acridinium Bromide
• Bretaris Genuair
• Eklira Genuair
• Genuair
• Las 34273
• Las-W 330
• Aclidinium bromide

Aclidinium (bromide)

CAS: 320345-99-1

Formula: C₂₆H₃₀BrNO₄S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 564.5547

Ref: IN-DA0039L9

(R)-3-(2-Hydroxy-2,2-Di(Thiophen-2-Yl)Acetoxy)-1-(3-Phenoxypropyl)Quinuclidin-1-Ium Bromide

CAS: 320345-99-1

(R)-3-(2-Hydroxy-2,2-Di(Thiophen-2-Yl)Acetoxy)-1-(3-Phenoxypropyl)Quinuclidin-1-Ium Bromide

Purity: 98%

Molecular weight: 564.55g/mol

Ref: 54-OR1026292

Aclidinium bromide

CAS: 320345-99-1

Aclidinium bromide

Purity: ≥98%

Molecular weight: 564.55g/mol

Ref: 54-BUP12951

Aclidinium Bromide

CAS: 320345-99-1

Formula: C₂₆H₃₀NO₄S₂·Br

Color and Shape: White To Off-White Solid

Molecular weight: 484.66 79.90

Ref: 4Z-A-211002

Aclidinium bromide

CAS: 320345-99-1

Aclidinium bromide (LAS-W 330) is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis.

Formula: C₂₆H₃₀NO₄S₂·Br

Purity: 99.53% - 99.69%

Color and Shape: Solid

Molecular weight: 564.55

Ref: TM-T2555

Aclidinium bromide

CAS: 320345-99-1

Muscarinic antagonist; bronchodilator

Formula: C₂₆H₃₀NO₄S₂·Br

Purity: Min. 95 Area-%

Color and Shape: Purple Powder

Molecular weight: 564.56 g/mol

Ref: 3D-FA31012

Aclidinium bromide - Bio-X ™

CAS: 320345-99-1

Aclidinium is a long-acting bronchodilator that is used to treat chronic cough and other symptoms of airway obstruction. It is also used to prevent bronchospasm in people who are at risk for developing asthma attacks. This drug binds to all 5 acetylcholine muscarinic receptor subtypes and results in bronchodilation.

Formula: C₂₆H₃₀NO₄S₂•Br

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 564.56 g/mol

Ref: 3D-BA300026

Aclidinium Bromide

Controlled Product

CAS: 320345-99-1

Applications Aclidinium Bromide is a novel long-acting antimuscarinic bronchodilator in phase II clinical trials for the treatment of chronic obstructive pulmonary disease (1,2).
References (1) Gupta, V. and Singh, D.: Expert Rev Respir Med. 6, 581 (2012) (2) De La Motte, S., et al.: Int. J. Clin. Pharmacol. Therap., 50,403 (2012)

Formula: C₂₆H₃₀NO₄S₂·Br

Color and Shape: Neat

Molecular weight: 564.55

Ref: TR-A190180

Aclidinium Bromide

CAS: 320345-99-1

Formula: C₂₆H₃₀NO₄S₂Br

Molecular weight: 484.66 : 79.90

Ref: ST-EA-CP-A308000