CAS 321-02-8

Nicotinic acid mononucleotide

Description:

Nicotinic acid mononucleotide (NAMN), with the CAS number 321-02-8, is a nucleotide that plays a crucial role in cellular metabolism and is a precursor to nicotinamide adenine dinucleotide (NAD+), an essential coenzyme in redox reactions. It consists of a nicotinic acid moiety linked to a ribose sugar and a phosphate group. NAMN is typically found in biological systems and is involved in various biochemical pathways, including those related to energy production and DNA repair. The substance is soluble in water, which facilitates its biological functions. Its structure allows it to participate in phosphorylation reactions, contributing to the synthesis of NAD+ and influencing cellular processes such as energy metabolism, signaling, and stress responses. Additionally, nicotinic acid mononucleotide has garnered interest in research related to aging and metabolic disorders, as NAD+ levels are known to decline with age, impacting cellular health and function. Overall, NAMN is a vital compound in biochemistry, linking vitamin B3 metabolism to essential cellular functions.

Formula: C₁₁H₁₄NO₉P

InChI: InChI=1S/C11H14NO9P/c13-8-7(5-20-22(17,18)19)21-10(9(8)14)12-3-1-2-6(4-12)11(15)16/h1-4,7-10,13-14H,5H2,(H2-,15,16,17,18,19)/t7-,8-,9-,10-/m1/s1

InChI key: InChIKey=JOUIQRNQJGXQDC-ZYUZMQFOSA-N

SMILES: O[C@H]1[C@@H](O[C@H](COP(=O)(O)O)[C@H]1O)[N+]=2C=C(C([O-])=O)C=CC2

Synonyms:

• 1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carboxylate
• 3-Carboxy-1-β-<span class="text-smallcaps">D</span>-ribofuranosylpyridinium hydroxide, 5′-phosphate, inner salt
• 3-Pyridinecarboxylic acid, mononucleotide
• 3-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium
• 3-carboxy-1-(5-O-phosphonopentofuranosyl)pyridinium
• Deamido nicotinamide ribonucleotide
• Deamido-NMN
• Nicotinate mononucleotide
• Nicotinate ribonucleotide
• Nicotinic acid ribonucleotide
• Nicotinic acid ribotide
• Nicotinic mononucleotide
• Pyridinium, 3-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)-, inner salt
• Pyridinium, 3-carboxy-1-(5-O-phosphono-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-, inner salt
• Pyridinium, 3-carboxy-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-, hydroxide, 5′-(dihydrogen phosphate), inner salt
• cyclohexane-1,4-diylbis[N-(2-chlorobenzyl)methanamine] dihydrochloride
• β-Nicotinic acid mononucleotide
• Pyridinium, 3-carboxy-1-(5-O-phosphono-β-D-ribofuranosyl)-, inner salt
• Nicotinic acid mononucleotide
• Pyridinium, 3-carboxy-1-β-D-ribofuranosyl-, hydroxide, 5′-(dihydrogen phosphate), inner salt
• 3-Carboxy-1-β-D-ribofuranosylpyridinium hydroxide, 5′-phosphate, inner salt

Nicotinic acid mononucleotide

CAS: 321-02-8

Nicotinic acid mononucleotide iss a key intermediate in the intracellular synthesis of NAD+, Coenzyme 1), closely associated with cellular metabolism.

Formula: C₁₁H₁₄NO₉P

Purity: 99.87%

Color and Shape: Solid

Molecular weight: 335.2

Ref: TM-T19477

Nicotinic acid mononucleotide

CAS: 321-02-8

Formula: C₁₁H₁₄NO₉P

Purity: 99%

Color and Shape: Solid

Molecular weight: 335.2039

Ref: IN-DA00C98M

Nicotinic acid mononucleotide

CAS: 321-02-8

Molecular weight: 335.20

Ref: 7W-GV2930

1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-((phosphonooxy)methyl)tetrahydrofuran-2-yl)pyridin-1-ium-3-carboxylate

CAS: 321-02-8

1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-((phosphonooxy)methyl)tetrahydrofuran-2-yl)pyridin-1-ium-3-carboxylate

Purity: 99%

Molecular weight: 335.21g/mol

Ref: 54-OR1066774

β-Nicotinic Acid Mononucleotide-d4

Controlled Product

CAS: 321-02-8

Stability Hygroscopic
Applications β-Nicotinic Acid Mononucleotide-d4 is the isotope labelled analog of β-Nicotinic Acid Mononucleotide (N429390); a nucleotide of nicotinic acid which is produced from quinolinic acid by quinolinate phosphoribosyltransferase via transfer of a phosphoribose group. It is an intermediate of nicotinic acid adenine dinucleotide (NaAD) which is then converted to NAD via amidation and in turn converted to NADPH.
References Petrelli, R. et al.: Curr. Med. Chem., 18, 1973 (2011); Shibata, K. et al.: J. Chrom. B Biomed. Sci. Appl., 749, 281 (2000); Evans, C. et al.: BMC Chem. Biol., 10, 2 (2010)

Formula: C₁₁H₁₀D₄NO₉P

Purity: >90%

Color and Shape: Neat

Molecular weight: 339.23

Ref: TR-N429393

β-Nicotinic Acid Mononucleotide

Controlled Product

CAS: 321-02-8

Stability Hygroscopic
Applications A nucleotide of nicotinic acid which is produced from quinolinic acid by quinolinate phosphoribosyltransferase via transfer of a phosphoribose group. It is an intermediate of nicotinic acid adenine dinucleotide (NaAD) which is then converted to NAD via amidation and in turn converted to NADPH.
References Petrelli, R. et al.: Curr. Med. Chem., 18, 1973 (2011); Shibata, K. et al.: J. Chrom. B Biomed. Sci. Appl., 749, 281 (2000); Evans, C. et al.: BMC Chem. Biol., 10, 2 (2010);

Formula: C₁₁H₁₄NO₉P

Color and Shape: Neat

Molecular weight: 335.2

Ref: TR-N429390

β-Nicotinic Acid Mononucleotide

CAS: 321-02-8

Formula: C₁₁H₁₄NO₉P

Molecular weight: 335.2

Ref: ST-EA-CP-A88111