CAS 321-64-2

Tacrine

Description:

Tacrine, with the CAS number 321-64-2, is a synthetic compound primarily known for its role as a cholinesterase inhibitor. It was one of the first drugs approved for the treatment of Alzheimer's disease, aimed at enhancing cognitive function by increasing the levels of acetylcholine in the brain. Tacrine is characterized by its relatively low solubility in water and its ability to cross the blood-brain barrier, which is crucial for its therapeutic effects. The compound has a complex structure that includes a bicyclic ring system, contributing to its biological activity. However, its clinical use has diminished due to side effects such as hepatotoxicity and gastrointestinal issues, leading to the development of newer, safer alternatives. Tacrine's pharmacokinetics involve hepatic metabolism, and it is primarily excreted through the liver. Despite its limited use today, Tacrine remains significant in the history of Alzheimer's treatment and serves as a reference point for the development of subsequent cholinesterase inhibitors.

Formula: C₁₃H₁₄N₂

InChI: InChI=1/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15)

InChI key: InChIKey=YLJREFDVOIBQDA-UHFFFAOYSA-N

SMILES: NC1=C2C(=NC=3C1=CC=CC3)CCCC2

Synonyms:

• 1,2,3,4-Tetrahydro-9-acridinamine
• 1,2,3,4-Tetrahydro-9-aminoacridine
• 1,2,3,4-Tetrahydro-acridin-9-ylamine
• 9-Acridinamine, 1,2,3,4-tetrahydro-
• 9-Amino-1,2,3,4-tetrahydroacridine
• Acridine, 9-amino-1,2,3,4-tetrahydro-
• Acridine, 9-aminotetrahydro-
• Cognex
• THA
• Tacrin
• Tacrina
• Tetrahydroaminacrine
• Tetrahydroaminoacridine
• Tetrahydroaminocrin
• Tetrahydroaminocrine
• 1,2,3,4-tetrahydro-9-acridinamin
• TIMTEC-BB SBB003560
• BUTTPARK 20\04-06
• 1,2,3,4-tetrahydro-9-amino-acridin
• AKOS 221-09
• 9-AMINOTETRAHYDROACRIDINE
• Acridine, 1,2,3,4-tetrahydro-9-amino-
• cs12602
• CS 12602
• 5-Amino-6,7,8,9-tetrahydroacridine

Tacrine

CAS: 321-64-2

Formula: C₁₃H₁₄N₂

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 198.27

Ref: 3B-T3994

1,2,3,4-Tetrahydro-9-acridinamine

CAS: 321-64-2

Formula: C₁₃H₁₄N₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 198.2637

Ref: IN-DA00C0A4

Tacrine

CAS: 321-64-2

Tacrine

Purity: ≥98%

Molecular weight: 198.26g/mol

Ref: 54-BUP15592

Tacrine

CAS: 321-64-2

Formula: C₁₃H₁₄N₂

Purity: ≥ 97.0%

Color and Shape: White to light-yellow crystalline powder

Molecular weight: 198.26

Ref: 7W-GP1913

1,2,3,4-Tetrahydro-9-Acridinamine

CAS: 321-64-2

1,2,3,4-Tetrahydro-9-Acridinamine

Purity: 98%

Molecular weight: 198.26g/mol

Ref: 54-OR1029655

Tacrine

CAS: 321-64-2

Tacrine (CS 12602) is an indirect cholinergic agonist and centrally acting anticholinesterase. It is approved for the treatment of Alzheimer's disease.

Formula: C₁₃H₁₄N₂

Purity: 99.97%

Color and Shape: Solid

Molecular weight: 198.26

Ref: TM-T21439

1,2,3,4-Tetrahydroacridin-9-amine

CAS: 321-64-2

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 198.2689971923828

Ref: 10-F210355

Tacrine

Controlled Product

CAS: 321-64-2

Tacrine is a drug that belongs to the class of nonsteroidal anti-inflammatory drugs. It is a cholinergic that is used for the treatment of Alzheimer's disease. Tacrine is potent inducers of cytochrome P450 enzymes and has been shown to have a significant drug interaction with α1-acid glycoprotein, which may lead to an increased risk of bleeding. Tacrine also inhibits neuronal death by binding to tetrahydroaminoacridine, which prevents it from being oxidized and then converted into hydrogen peroxide. This leads to an increase in acetylcholine levels and therefore improved cognitive function.

Formula: C₁₃H₁₄N₂

Purity: Min. 95%

Molecular weight: 198.26 g/mol

Ref: 3D-AAA32164