CAS 321674-73-1

BIBR 1532

Description:

BIBR 1532, with the CAS number 321674-73-1, is a chemical compound known for its role as a selective inhibitor of the enzyme phosphodiesterase 4 (PDE4). This inhibition is significant in the context of inflammatory diseases, as PDE4 plays a crucial role in the regulation of cyclic adenosine monophosphate (cAMP) levels within cells, influencing various signaling pathways. BIBR 1532 is characterized by its ability to modulate inflammatory responses, making it a subject of interest in pharmacological research, particularly for conditions such as asthma and chronic obstructive pulmonary disease (COPD). The compound typically exhibits good solubility in organic solvents and has been studied for its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion (ADME). Its selectivity for PDE4 over other phosphodiesterases is a key feature, as it minimizes potential side effects associated with broader inhibition. Overall, BIBR 1532 represents a valuable tool in the exploration of therapeutic strategies targeting inflammatory pathways.

Formula: C₂₁H₁₇NO₃

InChI: InChI=1/C21H17NO3/c1-14(16-11-10-15-6-2-3-7-17(15)13-16)12-20(23)22-19-9-5-4-8-18(19)21(24)25/h2-13H,1H3,(H,22,23)(H,24,25)/b14-12+

InChI key: InChIKey=PGFQXGLPJUCTOI-WYMLVPIESA-N

SMILES: C(=C\C(NC1=C(C(O)=O)C=CC=C1)=O)(\C)/C2=CC3=C(C=C2)C=CC=C3

Synonyms:

• 2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-buten-1-yl]amino]benzoic acid
• 2-{[(2E)-3-(2-Naphthyl)but-2-enoyl]amino}benzoic acid
• 2-{[(2E)-3-(naphthalen-2-yl)but-2-enoyl]amino}benzoic acid
• Benzoic acid, 2-[[(2E)-3-(2-naphthalenyl)-1-oxo-2-buten-1-yl]amino]-
• Benzoic acid, 2-[[(2E)-3-(2-naphthalenyl)-1-oxo-2-butenyl]amino]-
• Bibr 1532
• (E)-2-(3-(naphthalen-2-yl)but-2-enamido)benzoic acid
• 2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl]amino]benzoic acid
• BIBR 1532;BIBR-1532
• CS-1061
• 2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl1-yl]amino]benzoicacid
• (E)-2-(3-phenylbut-2-enamido)benzoic acid
• BIBR 1532, >=98%

(E)-2-(3-(Naphthalen-2-Yl)But-2-Enamido)Benzoic Acid

CAS: 321674-73-1

(E)-2-(3-(Naphthalen-2-Yl)But-2-Enamido)Benzoic Acid

Purity: 99%

Molecular weight: 331.36g/mol

Ref: 54-OR1025589

BIBR 1532

CAS: 321674-73-1

BIBR 1532

Purity: ≥98%

Molecular weight: 331.36g/mol

Ref: 54-BUP13391

BIBR 1532

CAS: 321674-73-1

Formula: C₂₁H₁₇NO₃

Purity: >95.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 331.37

Ref: 3B-B6502

BIBR 1532

CAS: 321674-73-1

BIBR 1532 is an effective, specific and non-competitive telomerase inhibitor (IC50: 100 nM, in a cell-free assay).

Formula: C₂₁H₁₇NO₃

Purity: 98.49% - 98.90%

Color and Shape: Solid

Molecular weight: 331.36

Ref: TM-T2380

BIBR 1532

Controlled Product

CAS: 321674-73-1

Applications BIBR 1532 is a mixed-type non-competitive inhibitor of telomerase. It specifically targets the telomerase reverse transcriptase catalytic subunit, TERT.
References Damm, K., et al.: EMBO J., 20, 6958 (2001); Kelland, L.: Eur. J. Cancer, 41, 971 (2005); Pascolo, E., et al.: J. Biol. Chem., 277, 15566 (2002)

Formula: C₂₁H₁₇NO₃

Color and Shape: Neat

Molecular weight: 331.36

Ref: TR-B375000