CAS 32188-09-3

(-)-Chlorpheniramine

Description:

(-)-Chlorpheniramine, with the CAS number 32188-09-3, is an antihistamine commonly used to relieve symptoms of allergy, hay fever, and the common cold. It is a member of the alkylamine class of antihistamines and is characterized by its ability to selectively block H1 histamine receptors, thereby reducing the effects of histamine in the body. This compound is typically administered orally and is known for its sedative properties, which can be attributed to its ability to cross the blood-brain barrier. (-)-Chlorpheniramine is often found in combination with other medications in over-the-counter cold and allergy remedies. Its chemical structure includes a chlorinated phenyl ring and an alkylamine side chain, contributing to its pharmacological activity. The substance is generally well-tolerated, but potential side effects may include drowsiness, dry mouth, and dizziness. As with any medication, it is important to use (-)-Chlorpheniramine under the guidance of a healthcare professional, especially in individuals with pre-existing health conditions or those taking other medications.

Formula: C₁₆H₁₉ClN₂

InChI: InChI=1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3/t15-/m1/s1

InChI key: InChIKey=SOYKEARSMXGVTM-OAHLLOKOSA-N

SMILES: [C@@H](CCN(C)C)(C1=CC=C(Cl)C=C1)C2=CC=CC=N2

Synonyms:

• (γR)-γ-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine
• 2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (R)-
• 2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (γR)-
• l-Chlorpheniramine
• Pyridine, 2-[p-chloro-α-[2-(dimethylamino)ethyl]benzyl]-, (-)-
• Pyridine, 2-[p-chloro-α-[2-(dimethylamino)ethyl]benzyl]-, (-)- (8CI)
• R-Chlorpheniramine
• (-)-2-[(R)-p-Chloro-α-[2-(dimethylamino)ethyl]benzyl]pyridine
• (R)-Chloropheniramine

(R)-Chloropheniramine

Controlled Product

CAS: 32188-09-3

Applications (R)-Chloropheniramine is an intermediate used in the synthesis of (R)-(-)-Chlorpheniramine Maleate (C424306), which is the R-enantiomer of Chlorpheniramine (C424300). Antihistaminic.
References Ishida, M., et al.: Int. J. Pharm., 359, 46 (2008), Moreno, R., et al.: Biomed. Chromatog., 24, 774 (2010), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),

Formula: C₁₆H₁₉ClN₂

Color and Shape: Neat

Molecular weight: 274.788

Ref: TR-C424295

(R)-Chloropheniramine

CAS: 32188-09-3

(R)-Chloropheniramine is an inhibitor that has been used to study the effects of kinase inhibitors on urine protein excretion. It is an analog of chlorpheniramine, which is commonly used as an antihistamine. (R)-Chloropheniramine has been shown to induce apoptosis in Chinese hamster ovary cells and human cancer cells, making it a potential anticancer agent. This drug has also been found to inhibit the growth of tumors in leukemia models, suggesting its potential use as a medicinal treatment for cancer. Its mechanism of action involves inhibiting proteins involved in cell growth and division, leading to decreased tumor size and proliferation.

Formula: C₁₆H₁₉ClN₂

Purity: Min. 95%

Molecular weight: 274.79 g/mol

Ref: 3D-HBA18809

Dexchlorpheniramine EP Impurity B

CAS: 32188-09-3

Formula: C₁₆H₁₉ClN₂

Molecular weight: 274.79

Ref: ST-EA-CP-C70015

Dexchlorpheniramine EP Impurity B

CAS: 32188-09-3

Formula: C₁₆H₁₉ClN₂

Molecular weight: 274.79

Ref: ST-EA-CP-D238004