CAS 3219-99-6

6-Epidoxycycline

Description:

6-Epidoxycycline is a semi-synthetic derivative of doxycycline, which is a member of the tetracycline class of antibiotics. It possesses a broad spectrum of antibacterial activity, making it effective against various Gram-positive and Gram-negative bacteria. The chemical structure of 6-Epidoxycycline includes a naphthacene core with specific functional groups that enhance its pharmacological properties. This compound is known for its ability to inhibit protein synthesis in bacteria by binding to the 30S ribosomal subunit, thereby preventing the translation process. Additionally, it exhibits anti-inflammatory properties and has been studied for its potential use in treating conditions beyond bacterial infections, such as acne and certain inflammatory diseases. The compound is typically administered orally and is characterized by its stability in acidic environments, which is advantageous for gastrointestinal absorption. As with other tetracyclines, it is important to consider potential side effects, including photosensitivity and gastrointestinal disturbances, as well as contraindications in certain populations, such as pregnant women and young children.

Formula: C₂₂H₂₄N₂O₈

InChI: InChI=1/C22H24N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31)/t7-,10-,14?,15+,17+,22+/m1/s1

InChI key: InChIKey=JBIWCJUYHHGXTC-IPJAVASBSA-N

SMILES: O[C@]12[C@]([C@H](N(C)C)C(O)=C(C(N)=O)C1=O)([C@@H](O)[C@]3(C(=C2O)C(=O)C=4C([C@H]3C)=CC=CC4O)[H])[H]

Synonyms:

• 6-Epioxytetracycline, 6-deoxy-
• (4S,4aR,5S,5aR,6S,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide
• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6S,12aS)-
• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, [4S-(4α,4aα,5α,5aα,6β,12aα)]-
• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, 6-epimer
• 6-Epi Doxycycline, >90%
• 6β-Deoxy-5-hydroxytetracycline
• Doxycycline Related Compound A (R073F0)
• 6-Deoxy-6-epioxytetracycline
• Doxycycline EP Impurity A/6-Epidoxycycline
• epi-Doxycycline
• 6-Epi Doxycycline, 65% (Contains Unknown Salts)
• Doxycycline Related Compound A ((4S,4aR,5S,5aR,6S,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octa (1226014)
• Doxycycline EP Impurity A(USP RC A)
• Doxycycline Impurity 1(Doxycycline EP Impurity A)
• (4S,4aR,5S,5aR,6S,12aS)-4-(Dimethylamino)
• Doxycycline Related Compound A (10 mg) (6-epidoxycycline)
• Discontinued-Replaced by E585925
• Doxycycline Related CoMpound A
• 6-Epi Doxycycline
• 6-epi-Doxycycline
• 6-epidoxycycline (Crude)
• Doxycycline EP Impurity A

Doxycycline EP Impurity A (6-epi Doxycycline)

CAS: 3219-99-6

Formula: C₂₂H₂₄N₂O₈

Molecular weight: 444.44

Ref: 4Z-D-186

Doxycycline EP Impurity A

CAS: 3219-99-6

Formula: C₂₂H₂₄N₂O₈

Molecular weight: 444.44

Ref: ST-EA-CP-D56001

6-Epi Doxycycline

CAS: 3219-99-6

Impurity Doxycycline Related Compound A
Stability Hygroscopic, Light Sensitive, Temperature Sensitive
Applications 6-Epi Doxycycline is an antibiotic used in the treatment of bacterial and certain parasitic infections. Doxycycline Related Compound A
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Jutglar, M., et al.: J. Pharm. Biomed. Anal., 159, 60 (2018); Metsemakers, W., et al.: J. Control. Release, 209, 47 (2015)

Formula: C₂₂H₂₄N₂O₈

Purity: >90%

Color and Shape: Yellow

Molecular weight: 444.43

Ref: TR-E585925

6-epi Doxycycline

CAS: 3219-99-6

6-epi Doxycycline is a structural isomer of doxycycline. It is produced by the reaction of sodium carbonate with 6-epi Doxycycline hydrochloride under high temperature and pressure, followed by purification by liquid chromatography. 6-epi Doxycycline can be used for pharmaceutical preparations, analytical methods and preparative purposes. Analytical methods for 6-epi Doxycycline include tests for impurities, such as chromatographic science and magnetic resonance spectroscopy. 6-epi Doxycycline has a dry weight of 196.2 g/mol and an anhydrous sodium content of 1.1%.

Formula: C₂₂H₂₄N₂O₈

Purity: 90%Min

Molecular weight: 444.43 g/mol

Ref: 3D-FE32558