CAS 3223-07-2

Melphalan hydrochloride

Description:

Melphalan hydrochloride is a synthetic alkylating agent primarily used in chemotherapy for the treatment of certain types of cancer, particularly multiple myeloma and ovarian cancer. It is a derivative of phenylalanine and belongs to the class of nitrogen mustards. The compound is characterized by its ability to form covalent bonds with DNA, leading to cross-linking and ultimately inhibiting DNA replication and transcription, which is crucial for cancer cell proliferation. Melphalan hydrochloride is typically administered intravenously or orally and is known for its moderate to high toxicity, necessitating careful monitoring of patients for side effects such as myelosuppression, gastrointestinal disturbances, and potential secondary malignancies. The substance is soluble in water and has a specific pH range for optimal stability. Its chemical structure includes a chloroethyl group, which is essential for its alkylating activity. Overall, Melphalan hydrochloride is an important therapeutic agent in oncology, with a well-established role in cancer treatment protocols.

Formula: C₁₃H₁₉Cl₃N₂O₂

InChI: InChI=1/C13H18Cl2N2O2.ClH/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19;/h1-4,12H,5-9,16H2,(H,18,19);1H/t12-;/m0./s1

InChI key: InChIKey=OUUYBRCCFUEMLH-YDALLXLXSA-N

SMILES: N(CCCl)(CCCl)C1=CC=C(C[C@@H](C(O)=O)N)C=C1.Cl

Synonyms:

• (S)-3-[4-[Bis(2-chloroethyl)amino]phenyl]alanine hydrochloride
• 2-{4-[Bis(2-Chloroethyl)Amino]Phenyl}-1-Carboxyethanaminium Chloride
• 4-Bis(2-chloroethyl)amino-<span class="text-smallcaps">L</span>-phenylalanine hydrochloride
• 4-[bis(2-chloroethyl)amino]-L-phenylalanine hydrochloride
• <span class="text-smallcaps">L</span>-Phenylalanine, 4-[bis(2-chloroethyl)amino]-, hydrochloride (1:1)
• <span class="text-smallcaps">L</span>-Phenylalanine, 4-[bis(2-chloroethyl)amino]-, monohydrochloride
• Alanine, 3-[p-[bis(2-chloroethyl)amino]phenyl]-, monohydrochloride, <span class="text-smallcaps">L</span>-
• L-Phenylalanine mustard hydrochloride
• L-Sarcolysine hydrochloride
• Phelinun
• Melphalan hydrochloride
• Alanine, 3-[p-[bis(2-chloroethyl)amino]phenyl]-, monohydrochloride, L-
• L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-, hydrochloride (1:1)
• L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-, monohydrochloride
• EVOMELA
• Melphalan Hydrochloride (100 mg) (International Restricted Sales Item)
• 2-AMINO-3-(4-(BIS(2-CHLOROETHYL)AMINO)PHENYL)PROPANOIC ACID HYDROCHLORIDE (MELPHALAN HYDROCHLORIDE)
• l-3-(p-(bis(2-chloroethyl)amino)phenyl)alaninemonohydrochloride
• Phenylalanine, 4-[bis(2-chloroethyl)amino]-, hydrochloride (1:1)
• Melphalan for system suitability
• alaninenitrogenmustardhydrochloride
• 3-(p-(bis(2-chloroethyl)amino)phenyl)-l-alaninhydrochloride
• phenylalaninemustardhydrochloride
• 4-BIS(2-CHLORETHYL)-AMINO-L-PHENYLALANINE HYDROCHLORIDE
• Melphalan hydrochloride CRS
• 4-(bis(2-chloroethyl)amino)-l-phenylalaninmonohydrochloride
• 4-[Bis(2-chloroethyl)amino]-L-phenylalanine hydrochloride (1:1)
• 3-(p-(bis(2-chloroethyl)amino)phenyl)-,monohydrochloride,l-alanin
• l-sarcolysinehydrochloride
• 4-BIS(2-CHLORETHYL)-AMINO-L-PHENYLALANINE HYDROCHLORIDE USP/EP/BP
• l-phenylalaninemustardhydrochloride

MELPHALAN HYDROCHLORIDE CRS

CAS: 3223-07-2

MELPHALAN HYDROCHLORIDE CRS

Ref: 41-Y0001158

Melphalan Hydrochloride

CAS: 3223-07-2

Aromatic amino-acids and their esters,other than those containing more than one kind of oxygen function for use as drugs

Formula: C₁₃H₁₈Cl₂N₂O₂·HCl

Color and Shape: Off-White Powder

Molecular weight: 304.07453

Ref: 45-1379300

Melphalan Hydrochloride

Controlled Product

CAS: 3223-07-2

Formula: C₁₃H₁₈Cl₂N₂O₂·ClH

Color and Shape: Neat

Molecular weight: 341.66

Ref: 86-MM0824.02

Melphalan Hydrochloride

Controlled Product

CAS: 3223-07-2

Stability Moisture Sensitive
Applications Melphalan Hydrochloride is used in combined intravitreal chemotherapy with topotecan hydrochloride for viable vitreous seeding from retinoblastoma. Also, it is an anti-cancer chemotherapy drug.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ghassemi, F., et al.: JAMA Ophthalmol., 132, 936-941 (2014); Gao, L. P., et al.: Adv. Mater. Res., 781-784, 993-998 (2013);

Formula: C₁₃H₁₈Cl₂N₂O₂·ClH

Color and Shape: Neat

Molecular weight: 341.66

Ref: TR-M216901

Melphalan hydrochloride

CAS: 3223-07-2

Nitrogen mustard derivative; DNA crosslinking agent; anti-cancer agent

Formula: C₁₃H₁₈Cl₂N₂O₂·HCl

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 341.66 g/mol

Ref: 3D-FM61588