CAS 32328-03-3

Diethyl 3-hydroxyglutarate

Description:

Diethyl 3-hydroxyglutarate is an organic compound characterized by its ester functional groups and a hydroxyl group attached to a glutaric acid derivative. It typically appears as a colorless to pale yellow liquid with a pleasant odor. The compound is soluble in organic solvents, such as ethanol and ether, but has limited solubility in water due to its hydrophobic diethyl ester groups. Diethyl 3-hydroxyglutarate is known for its role in organic synthesis, particularly in the preparation of various pharmaceuticals and agrochemicals. It can participate in reactions such as esterification and transesterification, making it a versatile intermediate in chemical synthesis. Additionally, it may exhibit biological activity, which can be of interest in medicinal chemistry. Safety data indicates that, like many organic compounds, it should be handled with care, as it may pose risks if ingested or inhaled. Proper storage conditions are essential to maintain its stability and prevent degradation.

Formula: C₉H₁₆O₅

InChI: InChI=1/C9H16O5/c1-3-13-8(11)5-7(10)6-9(12)14-4-2/h7,10H,3-6H2,1-2H3

InChI key: InChIKey=OLLQYIBTJXUEEX-UHFFFAOYSA-N

SMILES: C(CC(OCC)=O)(CC(OCC)=O)O

Synonyms:

• 1,5-Diethyl 3-hydroxypentanedioate
• 3-Hydroxyglutaric acid diethyl ester
• Diethyl 3-hydroxypentanedioate
• Diethyl-Beta-Hydroxyglutarate
• Glutaric acid, 3-hydroxy-, diethyl ester
• NSC 62681
• Pentanedioic acid, 3-hydroxy-, 1,5-diethyl ester
• Pentanedioic acid, 3-hydroxy-, diethyl ester
• Diethyl-3-hydroxyglutarate
• Diethyl 3-hydroxyglutarate

Diethyl 3-Hydroxyglutarate

CAS: 32328-03-3

Formula: C₉H₁₆O₅

Purity: >95.0%(GC)

Color and Shape: Colorless to Light yellow clear liquid

Molecular weight: 204.22

Ref: 3B-D3196

Diethyl 3-hydroxyglutarate

CAS: 32328-03-3

Formula: C₉H₁₆O₅

Purity: 98%

Color and Shape: Liquid

Molecular weight: 204.2203

Ref: IN-DA003PFR

Diethyl 3-hydroxyglutarate

CAS: 32328-03-3

Diethyl 3-hydroxyglutarate

Purity: 98%

Molecular weight: 204.22g/mol

Ref: 54-OR79313

Diethyl 3-hydroxyglutarate

CAS: 32328-03-3

Formula: C₉H₁₆O₅

Purity: 98%

Color and Shape: Liquid

Molecular weight: 204.222

Ref: 10-F221956

Diethyl 3-hydroxyglutarate

CAS: 32328-03-3

Diethyl 3-hydroxyglutarate is a chiral molecule that is used in the synthesis of pharmaceuticals. It has been shown to inhibit HMG-CoA reductase and is used as an inhibitor in drug development. Diethyl 3-hydroxyglutarate inhibits the enzyme HMG-CoA reductase, which catalyzes the conversion of HMG-CoA to mevalonic acid. This irreversible reaction provides the rate limiting step for cholesterol synthesis, and as such, inhibition of this enzyme leads to decreased levels of cholesterol in the body. The hydroxy group on diethyl 3-hydroxyglutarate can be deprotonated with a strong base such as LDA or LiHMDS to form an enolate anion that can react with electrophiles such as ketones or aldehydes to form keto esters or acetals. Diethyl 3-hydroxyglutarate also has lipase activity,

Formula: C₉H₁₆O₅

Purity: Min. 95%

Molecular weight: 204.22 g/mol

Ref: 3D-FD40458