CAS 32387-56-7

5-chloro-2'-deoxycytidine

Description:

5-Chloro-2'-deoxycytidine is a nucleoside analog that is structurally related to the natural nucleoside deoxycytidine. It features a chlorinated pyrimidine base, which is a modification of the cytosine base, and a deoxyribose sugar. This compound is characterized by its ability to interfere with DNA synthesis, making it of interest in antiviral and anticancer research. The presence of the chlorine atom at the 5-position of the pyrimidine ring enhances its biological activity by altering the hydrogen bonding properties and stability of the nucleic acid structures it incorporates into. 5-Chloro-2'-deoxycytidine is often studied for its potential therapeutic applications, particularly in the treatment of viral infections and certain types of cancer, as it can inhibit the replication of DNA in rapidly dividing cells. Additionally, its pharmacokinetic properties, such as absorption, distribution, metabolism, and excretion, are crucial for understanding its efficacy and safety in clinical settings.

Formula: C₉H₁₂ClN₃O₄

InChI: InChI=1/C9H12ClN3O4/c10-4-2-13(9(16)12-8(4)11)7-1-5(15)6(3-14)17-7/h2,5-7,14-15H,1,3H2,(H2,11,12,16)

SMILES: C1C(C(CO)OC1n1cc(c(=N)nc1O)Cl)O

Synonyms:

• 2'-Deoxy-5-chlorocytidine
• 5-Chlorodeoxycytidine
• Nsc 371331
• Cytidine, 5-chloro-2'-deoxy-
• 4-amino-5-chloro-1-(2-deoxypentofuranosyl)pyrimidin-2(1H)-one
• Cytochlor

4-Amino-5-chloro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

CAS: 32387-56-7

4-Amino-5-chloro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

Purity: 97%

Molecular weight: 261.67g/mol

Ref: 54-OR1058060

5-Chloro-2''-deoxycytidine

CAS: 32387-56-7

Ref: 7W-GN5330

5-Chloro-2'-deoxycytidine

CAS: 32387-56-7

5-Chloro-2'-deoxycytidine (5-Cl-dC) is a nucleoside analog that inhibits DNA synthesis by blocking the action of thymidylate synthase. It can be used in animal models to study bowel diseases, such as ulcerative colitis and Crohn's disease. 5-Cl-dC has been shown to be effective in treating the effects of radiation and chemical toxicity in HL60 cells, a type of human leukemia cell line. 5-Cl-dC has also been shown to enhance the cytotoxicity of eosinophil peroxidase, which is an enzyme that may be involved in the pathogenesis of asthma. This drug is currently being evaluated for its safety and efficacy in clinical trials involving patients with myelodysplastic syndrome or acute myeloid leukemia who are at risk for developing leukemia.

Formula: C₉H₁₂CIN₃O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 261.67 g/mol

Ref: 3D-NC08279