CAS 32780-64-6: Labetalol hydrochloride
Description:Labetalol hydrochloride is a pharmaceutical compound primarily used as an antihypertensive agent. It belongs to the class of medications known as beta-blockers, specifically a non-selective beta-adrenergic antagonist with additional alpha-1 adrenergic blocking properties. This dual action helps to lower blood pressure by reducing heart rate and dilating blood vessels. The substance is typically administered in the form of its hydrochloride salt, which enhances its solubility and bioavailability. Labetalol hydrochloride is characterized by its moderate lipophilicity, allowing it to cross biological membranes effectively. It is often prescribed for the management of hypertension, including hypertensive emergencies and in pregnant patients with gestational hypertension or preeclampsia. Common side effects may include dizziness, fatigue, and gastrointestinal disturbances. The compound is generally well-tolerated, but caution is advised in patients with asthma or certain cardiac conditions due to its non-selective beta-blocking effects. Overall, labetalol hydrochloride is a valuable medication in the therapeutic management of high blood pressure.
Formula:C19H24N2O3·ClH
InChI:InChI=1S/C19H24N2O3.ClH/c1-13(7-8-14-5-3-2-4-6-14)21-12-18(23)15-9-10-17(22)16(11-15)19(20)24;/h2-6,9-11,13,18,21-23H,7-8,12H2,1H3,(H2,20,24);1H
InChI key:InChIKey=WQVZLXWQESQGIF-UHFFFAOYSA-N
SMILES:Cl.O=C(N)C1=CC(=CC=C1O)C(O)CNC(C)CCC=2C=CC=CC2
- Synonyms:
- 2-Hydroxy-5-{1-Hydroxy-2-[(4-Phenylbutan-2-Yl)Amino]Ethyl}Benzamide
- 2-Hydroxy-5-{1-Hydroxy-2-[(4-Phenylbutan-2-Yl)Amino]Ethyl}Benzamide Hydrochloride (1:1)
- AH 5158 hydrochloride
- Ah 5158A
- Amipress
- Benzamide, 2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-, hydrochloride (1:1)
- Benzamide, 2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-, monohydrochloride
- Ipolab
- Labelol
- Labetalol HCl
- See more synonyms
- Labetalol Hydrochoride
- Labracol
- NSC 290312
- Normodyne
- Presdate
- Pressalolo
- Salicylamide, 5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-, monohydrochloride
- Sch 15719W
- Trandate
- Vescal
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