CAS 32780-64-6

Labetalol hydrochloride

Description:

Labetalol hydrochloride is a pharmaceutical compound primarily used as an antihypertensive agent. It belongs to the class of medications known as beta-blockers, specifically a non-selective beta-adrenergic antagonist with additional alpha-1 adrenergic blocking properties. This dual action helps to lower blood pressure by reducing heart rate and dilating blood vessels. The substance is typically administered in the form of its hydrochloride salt, which enhances its solubility and bioavailability. Labetalol hydrochloride is characterized by its moderate lipophilicity, allowing it to cross biological membranes effectively. It is often prescribed for the management of hypertension, including hypertensive emergencies and in pregnant patients with gestational hypertension or preeclampsia. Common side effects may include dizziness, fatigue, and gastrointestinal disturbances. The compound is generally well-tolerated, but caution is advised in patients with asthma or certain cardiac conditions due to its non-selective beta-blocking effects. Overall, labetalol hydrochloride is a valuable medication in the therapeutic management of high blood pressure.

Formula: C₁₉H₂₄N₂O₃·ClH

InChI: InChI=1S/C19H24N2O3.ClH/c1-13(7-8-14-5-3-2-4-6-14)21-12-18(23)15-9-10-17(22)16(11-15)19(20)24;/h2-6,9-11,13,18,21-23H,7-8,12H2,1H3,(H2,20,24);1H

InChI key: InChIKey=WQVZLXWQESQGIF-UHFFFAOYSA-N

SMILES: C(CNC(CCC1=CC=CC=C1)C)(O)C2=CC(C(N)=O)=C(O)C=C2.Cl

Synonyms:

• 2-Hydroxy-5-{1-Hydroxy-2-[(4-Phenylbutan-2-Yl)Amino]Ethyl}Benzamide
• 2-Hydroxy-5-{1-Hydroxy-2-[(4-Phenylbutan-2-Yl)Amino]Ethyl}Benzamide Hydrochloride (1:1)
• AH 5158 hydrochloride
• Ah 5158A
• Amipress
• Benzamide, 2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-, hydrochloride (1:1)
• Benzamide, 2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-, monohydrochloride
• Ipolab
• Labelol
• Labetalol HCl
• Labetalol Hydrochoride
• Labracol
• NSC 290312
• Normodyne
• Presdate
• Pressalolo
• Salicylamide, 5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-, monohydrochloride
• Sch 15719W
• Trandate

Labetalol Hydrochloride

CAS: 32780-64-6

Color and Shape: Neat

Ref: 61-FOR0438.00

LABETALOL HYDROCHLORIDE CRS

CAS: 32780-64-6

LABETALOL HYDROCHLORIDE CRS

Ref: 41-L0050000

Labetalol Hydrochloride

CAS: 32780-64-6

Aromatic cyclic amides (including cyclic carbamates) and their derivatives; salts thereof

Formula: C₁₉H₂₄N₂O₃·HCl

Color and Shape: White Off-White Crystalline Powder

Molecular weight: 364.15537

Ref: 45-1356654

2-Hydroxy-5-(1-hydroxy-2-(4-phenylbutan-2-ylamino)ethyl)benzamide HCl

CAS: 32780-64-6

Formula: C₁₉H₂₅ClN₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 364.8664

Ref: IN-DA0038TR

Labetalol hydrochloride

CAS: 32780-64-6

Labetalol hydrochloride (Sch-15719W), a salicylamide derivative, is a non-cardioselective blocker of β-adrenergic receptors and α1-adrenergic receptors.

Formula: C₁₉H₂₅ClN₂O₃

Purity: 99.54% - 99.85%

Color and Shape: Solid

Molecular weight: 364.87

Ref: TM-T0348

Labetalol hydrochloride

CAS: 32780-64-6

Formula: C₁₉H₂₄N₂O₃·HCl

Purity: 98.5 - 101.0 % (dried basis)

Color and Shape: White or almost white powder

Molecular weight: 364.87

Ref: 7W-GP7675

Labetalol HCl (Mixture of Diastereomers)

CAS: 32780-64-6

Formula: C₁₉H₂₄N₂O₃·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 328.41 36.46

Ref: 4Z-L-481

Labetalol hydrochloride

Controlled Product

CAS: 32780-64-6

Formula: C₁₉H₂₄N₂O₃·ClH

Color and Shape: Neat

Molecular weight: 364.87

Ref: 04-C14581010

Labetalol Hydrochloride

CAS: 32780-64-6

Color and Shape: Neat

Ref: 86-MM0438.00

Labetalol Hydrochloride

Controlled Product

CAS: 32780-64-6

Applications Labetalol is a specific competitive antagonist at both α-and β-adrenergic receptor sites. Labetalol is used as an antihypertensive.
References Sybertz, E.J. et al.: J. Pharmacol. Exp. Ther., 218, 435 (1981); Clifton, J.E. et al.: J. Med. Chem., 25, 670 (1982); Goa, K.L. et al.: Drugs, 37, 583 (1989);

Formula: C₁₉H₂₄N₂O₃·ClH

Color and Shape: White

Molecular weight: 364.87

Ref: TR-L096495

Labetalol hydrochloride

Controlled Product

CAS: 32780-64-6

Labetalol is a beta-adrenergic blocker that inhibits the binding of epinephrine to beta-adrenergic receptors. It has been shown to inhibit the activity of p-glycoprotein (P-gp) and prevent the movement of drugs out of cells. Labetalol also affects the activity of enzymes such as CYP3A4, CYP2D6, CYP2C9, and CYP2C19, which are responsible for metabolizing many different drugs. This drug also has a direct effect on cardiac function. Labetalol is used in treatment of high blood pressure, but should not be used in pregnant women because it can cause fetal harm. Labetalol may also interact with other cardiovascular medications (e.g., beta blockers).

Formula: C₁₉H₂₅ClN₂O₃

Purity: 95%Nmr

Color and Shape: White Powder

Molecular weight: 364.87 g/mol

Ref: 3D-FL61512

Labetalol-d3 Hydrochloride (Mixture of Diastereomers)

Controlled Product

CAS: 32780-64-6, 36894-69-6

Formula: C₁₉D₃H₂₁N₂O₃·HCl

Color and Shape: Neat

Molecular weight: 367.885

Ref: TR-L096497