CAS 32908-73-9

mast cell degranulating peptide

Description:

Mast cell degranulating peptide (CAS 32908-73-9) is a biologically active peptide that plays a significant role in the immune response, particularly in the activation and degranulation of mast cells. This peptide is derived from the venom of certain species, such as the wasp, and is known to induce the release of histamine and other inflammatory mediators from mast cells. Characteristically, mast cell degranulating peptide is a small, cationic peptide, which contributes to its ability to interact with cell membranes and promote degranulation. It is typically composed of a sequence of amino acids that facilitate its biological activity. The peptide is of interest in research related to allergic reactions, asthma, and other immune-related conditions due to its role in modulating inflammatory responses. Additionally, its structure and function make it a potential target for therapeutic interventions aimed at controlling mast cell-related disorders. Overall, mast cell degranulating peptide exemplifies the intricate interplay between peptides and immune system regulation.

Formula: C₁₁₀H₁₉₂N₄₀O₂₄S₄

InChI: InChI=1/C110H192N40O24S4/c1-11-58(7)83(118)103(169)136-66(30-17-22-38-113)94(160)142-77-53-176-175-51-75(89(155)128-50-82(153)131-64(28-15-20-36-111)90(156)138-71(88(119)154)46-80(116)151)144-106(172)85(59(8)12-2)147-95(161)67(31-18-23-39-114)132-92(158)68(33-25-41-126-109(120)121)135-100(166)78-54-178-177-52-76(143-96(162)74(47-81(117)152)140-101(77)167)99(165)134-65(29-16-21-37-112)91(157)133-69(34-26-42-127-110(122)123)93(159)139-72(44-62-48-124-55-129-62)97(163)146-84(57(5)6)104(170)149-87(61(10)14-4)105(171)137-70(32-19-24-40-115)108(174)150-43-27-35-79(150)102(168)141-73(45-63-49-125-56-130-63)98(164)148-86(60(9)13-3)107(173)145-78/h48-49,55-79,83-87H,11-47,50-54,111-115,118H2,1-10H3,(H2,116,151)(H2,117,152)(H2,119,154)(H,128,155)(H,131,153)(H,132,158)(H,133,157)(H,134,165)(H,135,166)(H,136,169)(H,137,171)(H,138,156)(H,139,159)(H,140,167)(H,141,168)(H,142,160)(H,143,162)(H,144,172)(H,145,173)(H,146,163)(H,147,161)(H,148,164)(H,149,170)(H4,120,121,126)(H4,122,123,127)

SMILES: CCC(C)C(C(=NC(CCCCN)C(=NC1CSSCC(C(=NCC(=NC(CCCCN)C(=NC(CC(=N)O)C(=N)O)O)O)O)N=C(C(C(C)CC)N=C(C(CCCCN)N=C(C(CCCNC(=N)N)N=C(C2CSSCC(C(=NC(CCCCN)C(=NC(CCCNC(=N)N)C(=NC(CC3C=NC=N3)C(=NC(C(C)C)C(=NC(C(C)CC)C(=NC(CCCCN)C(=O)N3CCCC3C(=NC(CC3C=NC=N3)C(=NC(C(C)CC)C(=N2)O)O)O)O)O)O)O)O)O)N=C(C(CC(=N)O)N=C1O)O)O)O)O)O)O)O)N

Synonyms:

• Peptide
• Mast cell degranulating peptide (honeybee reduced) cyclic (3-15),(5-19)-bis(disulfide)
• Peptide 401
• MCD peptide
• Mast cell degranulating peptide (honeybee)

Mast Cell Degranulating (MCD) Peptide

CAS: 32908-73-9

The highly basic MCD peptide is present in small amounts in the venom of the European honeybee, Apis mellifera. At low doses, it causes mast cell degranulation and subsequent histamine release. At higher doses, it produces an anti-inflammatory effect, which may be beneficial in rheumatic and allergic diseases.

Formula: C₁₁₀H₁₉₂N₄₀O₂₄S₄

Purity: 93.6%

Color and Shape: White

Molecular weight: 2587.25

Ref: 01-4030775

Peptide 401

CAS: 32908-73-9

Peptide 401: AMP from bee/wasp venom, triggers histamine release, reduces paw swelling.

Formula: C₁₁₀H₁₉₂N₄₀O₂₄S₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 2587.22

Ref: TM-TP1408

MCD-Peptide

CAS: 32908-73-9

A synthetic voltage-dependent K+ channel blocker derived from bee venom. This product is sourced from the Honeybee, Apis mellifera and has disulfide bonds between Cys3-Cys15 and Cys5-Cys19.
Available as a 0.5mg vial.

Formula: C₁₁₀H₁₉₂N₄₀O₂₄S₄

Purity: Min. 95%

Molecular weight: 2,587.2 g/mol

Ref: 3D-PMC-4258-V

Mast Cell Degranulating (MCD) Peptide

CAS: 32908-73-9

MCD peptide is present in small amounts in the venom of the European honeybee.  it causes mast cell degranulation and subsequent histamine release at low doses.  At high dose it produces an anti-inflammatory effect.

Formula: C₁₁₀H₁₉₂N₄₀O₂₄S₄

Purity: Min. 95%

Molecular weight: 2,587.22 g/mol

Ref: 3D-FM110262