CAS 32911-62-9

Withanolide A

Description:

Withanolide A is a naturally occurring steroidal lactone classified as a withanolide, which is a type of compound derived from the Solanaceae family, particularly from the plant Withania somnifera, commonly known as ashwagandha. This compound exhibits a range of biological activities, including anti-inflammatory, antioxidant, and potential anticancer properties. Withanolide A is characterized by its unique steroidal structure, which includes a fused cyclopentanoperhydrophenanthrene core and a lactone ring. It is typically found in a crystalline form and is soluble in organic solvents but has limited solubility in water. The compound has garnered interest in pharmacological research due to its ability to modulate various signaling pathways and its potential therapeutic applications in stress relief, neuroprotection, and immune system enhancement. Its safety profile and efficacy are subjects of ongoing studies, making it a significant focus in natural product chemistry and medicinal research.

Formula: C₂₈H₃₈O₆

InChI: InChI=1S/C28H38O6/c1-14-13-20(33-24(30)15(14)2)27(5,31)18-9-8-16-21-17(10-12-25(16,18)3)26(4)19(29)7-6-11-28(26,32)23-22(21)34-23/h6-7,16-18,20-23,31-32H,8-13H2,1-5H3/t16-,17-,18-,20+,21-,22-,23-,25-,26-,27+,28-/m0/s1

InChI key: InChIKey=DXWHOKCXBGLTMQ-SFQAJKIESA-N

SMILES: C[C@@]12[C@@]3([C@@]([C@]4([C@](O4)([C@@]1(O)CC=CC2=O)[H])[H])([C@]5([C@](C)(CC3)[C@@]([C@@](C)(O)[C@]6(CC(C)=C(C)C(=O)O6)[H])(CC5)[H])[H])[H])[H]

Synonyms:

• 5,20a-Dihydroxy-6a,7a-epoxy-1-oxowitha-2,24-dienolide
• 5a,20aF(R)-Dihydroxy-6a,7a-epoxy-1-oxowitha-2,24-dienolide
• 5a-Ergosta-2,24-dien-26-oic acid, 6a,7a-epoxy-5,20,22-trihydroxy-1-oxo-, d-lactone, (22R)- (8CI)
• 5α,20α_F(R)-Dihydroxy-6α,7α-epoxy-1-oxowitha-2,24-dienolide
• 5α-Ergosta-2,24-dien-26-oic acid, 6α,7α-epoxy-5,20,22-trihydroxy-1-oxo-, δ-lactone, (22R)-
• 6,7-Epoxy-1H-cyclopenta[a]phenanthrene, ergosta-2,24-dien-26-oic acid deriv.
• Ergosta-2,24-dien-26-oic acid, 6,7-epoxy-5,20,22-trihydroxy-1-oxo-, δ-lactone, (5α,6α,7α,22R)-
• Withaniol
• Withanolide A

Withanolide A

CAS: 32911-62-9

Lactones, nesoi

Formula: C₂₈H₃₈O₆

Color and Shape: White Powder

Molecular weight: 470.26684

Ref: 45-1719500

WITHANOLIDE A(P)

CAS: 32911-62-9

Formula: C₂₈H₃₈O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 470.5977

Ref: IN-DA00C0X8

Withanolide A

CAS: 32911-62-9

Withanolide A

Purity: ≥98%

Molecular weight: 470.6g/mol

Ref: 54-BUP00903

Withanolide A

CAS: 32911-62-9

Formula: C₂₈H₃₈O₆

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 470.61

Ref: 7W-GY0544

Withanolide A

CAS: 32911-62-9

Formula: C₂₈H₃₈O₆

Purity: 95%~99%

Molecular weight: 470.606

Ref: BP-BP4207

Withanolide A

CAS: 32911-62-9

Formula: C₂₈H₃₈O₆

Molecular weight: 470.61

Ref: 4Z-W-008001

Withanolide A

CAS: 32911-62-9

Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans.

Formula: C₂₈H₃₈O₆

Purity: 98.49% - 99.5%

Color and Shape: Solid

Molecular weight: 470.6

Ref: TM-TN2309

Withanolide a

CAS: 32911-62-9

Lactone

Formula: C₂₈H₃₈O₆

Purity: ≥ 90.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 470.61

Ref: 5G-80556

Withanolide A

Controlled Product

CAS: 32911-62-9

Applications Withanolide A, is a neuritogenic steroid. It may act as deterrent for feeding insect larva and other herbivores. Withaferin A, causes activation of Notch2 and Notch4 in human breast cancer cells, and thus used as novel anticancer agents.
References Liffert, R., et al.: Chemical Science, 4, 2851 (2013); Lee. J., et al.: Breast Cancer, Res. treat., 136, 45 (2012);

Formula: C₂₈H₃₈O₆

Color and Shape: Neat

Molecular weight: 470.60

Ref: TR-W498950

Withanolide A

CAS: 32911-62-9

Natural steroid with anti-neurodegenerative properties

Formula: C₂₈H₃₈O₆

Purity: Min. 95%

Molecular weight: 470.6 g/mol

Ref: 3D-XW164988