CAS 32926-43-5

N(alpha)-boc-N(im)-trityl-L-histidine

Description:

N(alpha)-Boc-N(im)-trityl-L-histidine is a protected derivative of the amino acid histidine, commonly used in peptide synthesis and research. The "Boc" (tert-butyloxycarbonyl) group serves as a protective group for the amino group, while the "trityl" group protects the imidazole side chain, enhancing the stability and solubility of the compound during synthesis. This compound retains the essential characteristics of histidine, including its ability to participate in acid-base reactions due to the imidazole ring, which can act as both a proton donor and acceptor. The presence of these protective groups allows for selective reactions at specific sites, facilitating the synthesis of more complex peptides. N(alpha)-Boc-N(im)-trityl-L-histidine is typically utilized in solid-phase peptide synthesis and can be converted back to the free amino acid form through deprotection steps. Its structural features make it valuable in the development of pharmaceuticals and bioconjugates, where precise control over amino acid functionality is crucial.

Formula: C₃₀H₃₁N₃O₄

InChI: InChI=1/C30H31N3O4/c1-29(2,3)37-28(36)32-26(27(34)35)19-25-20-33(21-31-25)30(22-13-7-4-8-14-22,23-15-9-5-10-16-23)24-17-11-6-12-18-24/h4-18,20-21,26H,19H2,1-3H3,(H,32,36)(H,34,35)/t26-/m0/s1

SMILES: CC(C)(C)OC(=N[C@@H](Cc1cn(cn1)C(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)O)O

Synonyms:

• Boc-His(Trt)-OH
• N-(tert-butoxycarbonyl)-1-trityl-L-histidine
• N-Boc-N'-trityl-L-histidine
• Boc-L-His(Trt)-OH

(S)-L-Boc-His(Trt)-OH

CAS: 32926-43-5

Formula: C₃₀H₃₁N₃O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 497.5848

Ref: IN-DA0035D4

Boc-His(Trt)-OH

CAS: 32926-43-5

Molecular weight: 497.58

Ref: 7W-GM9956

Boc-His(Trt)-OH

Controlled Product

CAS: 32926-43-5

Applications Boc-His(Trt)-OH was used in the study to prepare and study structure-activity relationship of amino acid amides as selective inhibitors for dipeptidyl peptidases.
References Senten, K., et al.: J. Med. Chem., 46, 5005 (2003);

Formula: C₃₀H₃₁N₃O₄

Color and Shape: White To Off-White

Molecular weight: 497.58

Ref: TR-B656218

boc-his(trt)-oh

CAS: 32926-43-5

Formula: C₃₀H₃₁N₃O₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 497.595

Ref: 10-F045435

Boc-His(Trt)-OH

CAS: 32926-43-5

Boc-His(Trt)-OH is a chemical compound that has been used in the laboratory to study uptake and binding of compounds. It is stable in complex with albumin, which has led to its use as a model system for studying hepatic steatosis. This chemical can be synthesized by solid-phase synthesis with trifluoroacetic acid and polypeptide synthesis. FT-IR spectroscopy has been used to characterize Boc-His(Trt)-OH, revealing its chemical diversity.

Formula: C₃₀H₃₁N₃O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 497.58 g/mol

Ref: 3D-FB42925